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Dissolvable nasal sinus sponge

A sponge, solution technology, applied in extracellular fluid diseases, antibacterial drugs, drug combinations, etc., can solve problems such as infection, patient pain, and no therapeutic benefit

Active Publication Date: 2018-08-03
MEDTRONIC INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Removal of the nasal stent can cause pain for the patient and lead to scarring or rebleeding
Furthermore, those conventional stents that are dissolvable or crumbleable may not provide any therapeutic benefit and thus may cause infection due to the specific material used in the stent

Method used

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  • Dissolvable nasal sinus sponge
  • Dissolvable nasal sinus sponge
  • Dissolvable nasal sinus sponge

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0056] Example 1: Formation of Dissolving Sponge

[0057] About 4.8 grams of hydroxyethylcellulose with a molecular weight of ~750k and 3.2 grams of hydroxyethylcellulose with a molecular weight of ~1.3M were placed in a beaker and mixed thoroughly. Then 350ml of water was added to the beaker with hydroxyethylcellulose. The mixture was then heated to a temperature of about 30-40° C. at about 100-150 RPM using a hot plate and an overhead mixer with a paddle link for 1.5-2 hours until the material was clear (not cloudy) and all lumps were complete dissolve. Then, the pH of the hydroxyethylcellulose solution was adjusted to 3 to 4 using hydrochloric acid. Separately, about 2 g of chitosan HCL was put into a beaker, and then about 50 ml of water was added. Mix the chitosan-HCl solution using a stirring plate with a stir bar until the chitosan-HCl is completely dissolved and the color is yellow. The chitosan solution was then added to the hydroxyethyl cellulose solution while s...

Embodiment 2-6

[0058] Example 2-6: Effect of Solution Viscosity on Sponge Formation

[0059] The initial solution with 2.5% solids prepared according to Example 1 was then diluted from 2.5% to 1.25% (50% dilution), 0.625%, 0, 3125%, 0.151%, 0.0756% to form Examples 2-6 . The solution was then formed into a sponge in the same manner as described in Example 1 above. A sponge having a solid content of 0.5% by weight or higher and a viscosity of 0.05 Pa·s or higher is formed. Viscosity, weight percent solids, and sponge mass are reported in Table 2. Examples 4, 5, 6 (Table 2) did not form solid sponges.

[0060] Table 2

[0061]

Embodiment 7-9

[0062] Examples 7-9: Adhesion test

[0063] The sponges produced according to the examples were cut in half and placed in separate trays (1 / 2 sponge) and hydrated with water (8ml). The sponge was then allowed to dry overnight at room temperature. The sponges were then tested for adhesion. The results, reported in Table 3, indicated that the hydrated sponges were mucoadhesive with an average adhesion force of 37 grams of force.

[0064] table 3

[0065] Example

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Abstract

An implantable article comprises a dissolvable sponge derived from the mixture of chitosan, a first polysaccharide and a second polysaccharides. The polysaccharides have different number average molecular weight characteristics to enable the control of the mechanical features of the sponge.

Description

[0001] Cross References to Related Applications [0002] This application claims the benefit of US Provisional Application Serial No. 14 / 962,493, entitled "Dissolvable Sinus Sponge," filed December 8, 2015, the contents of which are incorporated herein by reference. field of invention [0003] The present invention relates to dissolvable sponges or scaffolds for use in or on tissues and structures in the nasal passages or other parts of the anatomy. Background technique [0004] Nasal packings and sponges (stents) are used to keep the nasal cavity open (stenting), absorb fluid or blood, and prevent adhesions in the nasal cavity after sinus surgery. A recognized problem with conventional nasal stents currently on the market is that they must be removed after surgery. Removal of the nasal stent may cause pain to the patient and lead to scarring or rebleeding. Furthermore, those conventional stents that are dissolvable or crumbling may not provide any therapeutic benefit, and...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61F13/20A61K9/00A61L15/22
CPCA61K9/0043A61F13/2005A61L24/043A61L24/0015A61L24/0036A61L24/0042A61P11/02A61P17/02A61P31/04A61P41/00A61P43/00A61P7/04C08L5/08A61F13/36A61L24/08A61L31/042A61L31/146A61L31/148A61L31/16A61L2300/404A61L2/0029A61L2202/24A61L2300/232A61L2400/04B65B55/16B65B63/08A61L15/225
Inventor E·G·舍曼W·陈D·E·冈瑟
Owner MEDTRONIC INC
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