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Weight-reducing application of apios americana medikus tuber ethanol extract

A technology of ethanol extraction and bean taro, which is applied in the field of medicine, can solve the problems that the weight loss activity of ethanol extracts of bean taro tubers is rarely reported, and achieve the prevention of obesity and related chronic diseases, alleviating weight gain, and significant effects Effect

Inactive Publication Date: 2018-08-07
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, many nutrition and health food researchers are currently paying close attention to the research and topics related to the occurrence and prevention of obesity and chronic diseases, but there are few reports on the weight loss activity of bean and taro tuber ethanol extracts

Method used

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  • Weight-reducing application of apios americana medikus tuber ethanol extract

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047] Embodiment 1, the weight-reducing purposes of bean taro tuber ethanol extract, such as Figure 1-Figure 5 It has been shown that the ethanol extract of bean and taro tubers has significant weight loss and lipid-lowering effects.

[0048] The specific preparation steps of the bean taro tuber ethanol extract are as follows:

[0049] (1) According to the solid-liquid ratio of 1 g: 5 ml, after mixing the bean and taro tubers with 95% ethanol containing 0.1 mol / L hydrochloric acid, they are processed and beaten through a juice extractor. The obtained slurry was leached by ultrasonic (ultrasonic frequency of 40,000 Hz) for 240 min at 45° C., the extract was centrifuged at 4000 rpm for 30 min, and the extract was centrifuged to obtain a supernatant.

[0050](2), the centrifuged filter residue of step (1) gained replaces the potato tuber in step (1), repeats extraction 2 times, merges filtrate three times, the supernatant of gained is in rotary evaporator (rotary evaporating p...

Embodiment 2

[0062] Embodiment 2, the influence of the ethanol extract of bean taro tuber on fat of obese mice, liver and other organs;

[0063] Fasted for 24 hours after 12 weeks of intragastric administration in Example 1, weighed the body weight, and killed the mice by cervical dislocation after blood was taken from the orbits. The fat around the kidneys and epididymis was taken, and the heart, liver, spleen, and kidney were quickly removed. , brown fat and other tissues and record the weight, the specific data are shown in Table 1.

[0064] Table 1 Effects of Ethanol Extract Intervention of Bean and Taro Tubers on the Organ Index of Mice

[0065]

[0066] According to Table 1, different doses of ethanol extracts of bean and taro tubers can significantly reduce the peritesticular fat and perirenal fat index in obese mice, and the high-dose group can significantly increase the pancreas index. Compared with the high-fat control group, bean and taro tuber The ethanol extract interventi...

Embodiment 3

[0067] Embodiment 3, the ethanol extract of bean taro tuber is to the influence of obese mouse serum triglyceride, total cholesterol, alanine aminotransferase and aspartate aminotransferase content;

[0068] The mice after 12 weeks of intragastric administration in Example 1 were fasted for 24 hours, and the mice were killed by cervical dislocation after blood was taken from the eye sockets. The blood samples were centrifuged at 1500 rpm for 15 minutes, and the serum was taken and preserved, and the glycerol in the serum was analyzed by a Toshiba automatic biochemical analyzer. The contents of triester and total cholesterol were determined, and the specific data are shown in Table 2.

[0069] Table 2 Effects of Ethanol Extract Intervention of Bean and Taro Tubers on Serum Index of Mice

[0070]

[0071] According to Table 2, it can be seen that the intervention of high-dose ethanol extract of bean and taro tubers can reduce the total cholesterol content in the serum of obes...

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Abstract

The invention discloses weight-reducing application of an apios americana medikus tuber ethanol extract, and provides a new resource for developing natural weight-losing products in the fields such asmedicine and food science. By inducing a small fat mouse through high fat diet, the experimental evaluation proves that the apios americana medikus tuber ethanol extract can be used for remarkably reducing the weight of the small fat mouse and lowering the content of triglyceride and total cholesterol in serum and livers, and has comprehensive and remarkable effects. Therefore, the apios americana medikus tuber ethanol extract is applied to preparation of weight-reducing food or drugs so as to treat and prevent obesity and chronic diseases relevant to the obesity.

Description

technical field [0001] The invention relates to the field of medicine, in particular to the weight-loss application of ethanol extract of bean and taro tubers. Background technique [0002] Apios americana Medikus is a perennial leguminous plant (Papilionaceae subfamily) native to the eastern part of North America from Canada to the southern part of Florida. Its edible part is the underground tuber, and its protein content is higher than that of other plant tubers. It is a crop with both nutrition and economic value, so it is often used as a staple food by Indians. Bean taro has been successfully introduced in China since 2009, and has been gradually promoted and planted in Fuyang, Jinhua, Longyou, Wenzhou and other places. Studies have shown that different parts of taro (flowers, vines, leaves, tubers) are rich in free amino acids, soluble proteins, polysaccharides, saponins, flavonoids, isoflavones, vitamin C, vitamin E and minerals. Among them, bean and taro tubers cont...

Claims

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Application Information

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IPC IPC(8): A61K36/48A61P3/04A61P3/06A23L33/105A61K125/00
CPCA61K36/48A23L33/105A23V2002/00A61K2236/333A61K2236/39A61K2236/51A61K2236/55A61P3/04A61P3/06A23V2250/21A23V2200/3262A23V2200/3324
Inventor 郑晓冬楚强叶映凡俞露霜刘阳阳李永璐
Owner ZHEJIANG UNIV
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