A kind of preparation method of bone repair material

A technology of bone repair and mass ratio, which is applied in the fields of prosthesis, tissue regeneration, medical science, etc., can solve the problems of poor BMP-2 biocompatibility and limited brittleness of bone repair materials, and achieve good osteoinductive activity, No immune rejection, increased antibacterial properties

Active Publication Date: 2020-03-24
ZHEJIANG RISING BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] In order to overcome the deficiencies of the prior art, the object of the present invention is to provide a method for preparing bone repair materials, which can solve the problems of poor biocompatibility of BMP-2, limitations and brittleness of bone repair materials in the use of body parts The problem

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] A method for preparing a bone repair material, characterized in that it comprises the steps of:

[0032] Step 1: Accurately weigh 20 mg of lecithin and 1 mg of human bone morphogenetic protein-2 according to the ratio, and add them into an agate mortar for grinding, so that the bone morphogenetic protein-2 is evenly dispersed in the lecithin;

[0033] Step 2: Add 4 mg of chitosan and 0.3 mg of hydroxyapatite composition in the mortar, and grind until uniformly dispersed; the chitosan added in the material, due to the special antibacterial properties of chitosan, is the product Increased antibacterial performance; the hydroxyapatite composition is a combination of hydroxyapatite and polyamide. Due to its good biomechanical properties, and the material is very similar to human skin, it is more conducive to cell adhesion, growth and Splitting is more conducive to the transmission of nutrients and timely discharge of excreta, which can effectively improve the clinical treat...

Embodiment 2

[0040] A method for preparing a bone repair material, characterized in that it comprises the steps of:

[0041] Step 1: Accurately weigh 35 mg of lecithin and 1 mg of human bone morphogenetic protein-2 according to the ratio, and add them into an agate mortar for grinding, so that bone morphogenetic protein-2 is evenly dispersed in the lecithin;

[0042] Step 2: Add 18 mg of chitosan and 3.1 mg of hydroxyapatite composition in the mortar, and grind to uniform dispersion; the chitosan added in the material, due to the special antibacterial properties of chitosan, is the product Increased antibacterial performance; the hydroxyapatite composition is a combination of hydroxyapatite and polyamide. Due to its good biomechanical properties, and the material is very similar to human skin, it is more conducive to cell adhesion, growth and Splitting is more conducive to the transmission of nutrients and the timely discharge of excreta, which can effectively improve the clinical treatmen...

Embodiment 3

[0049] A method for preparing a bone repair material, characterized in that it comprises the steps of:

[0050] Step 1: Accurately weigh 50 mg of lecithin and 1 mg of human bone morphogenetic protein-2 according to the ratio, and add them into an agate mortar for grinding, so that bone morphogenetic protein-2 is evenly dispersed in the lecithin;

[0051] Step 2: Add 32mg of chitosan and 6mg of hydroxyapatite composition to the mortar, and grind until evenly dispersed; the chitosan added to the material, due to the special antibacterial properties of chitosan, adds to the product Antibacterial performance; the hydroxyapatite composition is a combination of hydroxyapatite and polyamide. Due to its good biomechanical properties, and the material is very similar to human skin, it is more conducive to cell adhesion, growth and division , which is more conducive to the transmission of nutrients and the timely discharge of excreta, which can effectively improve the clinical treatment...

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Abstract

The invention discloses a preparation method of a bone repair material. The preparation method comprises the following steps: accurately weighing 20-50 parts by mass of lecithin and 1 part by mass ofhuman bone morphogenetic protein-2 proportionally, and performing grinding in a mortar to enable the bone morphogenetic protein-2 to be uniformly dispersed in the lecithin; adding 4-32 parts by mass of chitosan and 0.3-6 parts by mass of hydroxyapatite composition to the mortar, and performing grinding until the chitosan and the hydroxyapatite composition are uniformly dispersed; weighing 10-80 parts by mass of gelatin, and adding 100-800 parts by mass of water to be prepared into 10% liquid gelatin; and adding the prepared 10% liquid gelatin to the mortar in the step 2, performing continuousgrinding until a uniform suspension is formed, and performing separate packaging to obtain scaffold products. The prepared material has good biocompatibility, is free of immunological rejection reaction, has good biomechanical properties, and improves the relatively brittle characteristic of hydroxyapatite; and the material is very similar to human skin so as to be more favorable for adhesion, growth and division of cells, transfer of nutrient substances as well as timely discharge of excrement, so that the clinical treatment effect can be effectively improved.

Description

technical field [0001] The invention relates to the technical field of bone repair, in particular to a preparation method of a bone repair material. Background technique [0002] Bone transplantation has been widely used in the field of orthopedics, mainly for the treatment of bone defects, nonunions and other diseases caused by tumors, trauma, deformities, etc. Bone repair is a problem that has been explored but not completely resolved in the field of orthopedics. Bone transplantation has changed from simply restoring bone structure to pursuing bionic bone reconstruction, and strives for rapid integration of grafted bone, so that bone transplantation approaches physiological bone reconstruction. Bone transplantation has developed from autologous bone transplantation and allogeneic bone transplantation to artificial bone transplantation and tissue engineering bone transplantation. [0003] Autologous bone grafting is the removal of bone from one's own body, usually cortical...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/20A61L27/18A61L27/12A61L27/10A61L27/22A61L27/50A61L27/54A61L27/56
CPCA61L27/10A61L27/12A61L27/18A61L27/20A61L27/222A61L27/50A61L27/54A61L27/56A61L2300/414A61L2300/602A61L2430/02C08L5/08C08L77/00
Inventor 曹建新
Owner ZHEJIANG RISING BIOTECH CO LTD
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