Composition for treating skin immune diseases as well as preparation method thereof

A technology of immune diseases and compositions, applied in the field of medicine, can solve problems such as many adverse reactions of systemic treatment, difficulties in psoriasis treatment, physical and mental impact of patients, etc., achieve efficient, simple and controllable preparation process, and good retention of skin targeting , the effect of convenient administration

Active Publication Date: 2018-08-28
SUN YAT SEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The treatment of psoriasis is difficult, and there are many adverse reactions of systemic treatment. Most of the topical drugs contain glucocorticoids, which are easy to cause dependence and recurrence, and are difficult to treat and easy to occur. The patient's body and mind are greatly affected.

Method used

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  • Composition for treating skin immune diseases as well as preparation method thereof
  • Composition for treating skin immune diseases as well as preparation method thereof
  • Composition for treating skin immune diseases as well as preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] Embodiment 1 A kind of composition for the treatment of skin immune disease

[0037] The present embodiment composition comprises the following raw materials by mass percentage:

[0038]

[0039] The preparation method of this embodiment composition:

[0040] A. According to the formula ratio, at room temperature, menthol and camphor are ground to form a transparent and clear solution;

[0041] B. According to the formula ratio, add tacrolimus into Transcutol P, and stir until the drug is completely dissolved;

[0042] C. According to the formula ratio, at room temperature, add the transparent and clear solution in step A and Cremophor EL to the solution described in step B sequentially under stirring until uniform and stable concentrated milk is formed;

[0043] D. According to the formula ratio, slowly add water into the solution described in step C, and keep stirring until it is transparent and clear.

Embodiment 2

[0044] Embodiment 2 A kind of compound gel for the treatment of skin immune disease

[0045] First by following charge ratio and with the preparation method identical with embodiment 1, make composition:

[0046]

[0047] Then add the composition to 0.5% carbomer aqueous solution containing propylene glycol and benzyl alcohol, the concentration of the composition is 10%, mix well, then add triethanolamine to adjust the pH to 4.5-5.5, stir until transparent and uniform gel form.

[0048]Therefore, the final prescription of the compound gel for the treatment of skin immune diseases in this embodiment is:

[0049]

[0050] Next, the composition and compound gel for treating skin immune diseases prepared by the present invention are further tested for their effects.

[0051] 1. Transdermal detection experiment

[0052] The above-mentioned composition for treating immune diseases of the skin (hereinafter referred to as the composition), the compound gel (hereinafter referr...

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Abstract

The invention discloses a composition for treating skin immune diseases as well as a preparation method thereof. The composition comprises the following raw materials: tacrolimus, camphor, menthol andthe like. Compared with protopic, the product has similar penetrating effect, but has higher skin targeting property of skin retention. The medicine effect result of animal atopic dermatitis indicates that the tacrolimus composition and the gel have remarkable curative effects in the aspects of improving specific dermatitis erythema / hemorrhage, edema and infiltration / erosion atmospheres. Meanwhile, the composition and the gel are convenient to administrate, have high application property, high spreadability on skin and high moisture retaining property, has the effects of cooling and relievingitching, can obviously reduce adverse effects, such as stabbing pain, pruritus, burning sensation and erythema fugax, caused by low protopic, and can improve the treatment effect of the atopic dermatitis. The instrument and equipment are simple and convenient, the preparation process is efficient, simple and controllable, and the preparation method is suitable for industrialized production.

Description

technical field [0001] The invention belongs to the technical field of medicine, and relates to a composition for solubilizing and synergistically promoting the drug effect of tacrolimus and a preparation method thereof. Background technique [0002] Tacrolimus is a macrolide immunomodulator. It inhibits the dephosphorylation of calcineurin, interferes with the expression of cytokines, and down-regulates the activation of T cells. Appropriate dermatitis (eczema), psoriasis, vitiligo and other indications. The commercially available formulation of tacrolimus is an ointment prepared from an oily base, and the trade name is Protopic Approved by the FDA, it can be used to treat atopic dermatitis and eczema in adults and children respectively, and it has gradually developed to treat immune skin diseases such as psoriasis and vitiligo in clinical practice. However, when tacrolimus ointment is administered transdermally, its percutaneous absorption is limited due to its high hyd...

Claims

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Application Information

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IPC IPC(8): A61K31/436A61K9/06A61K47/10A61K47/08A61P17/00A61P37/08A61P17/06
CPCA61K9/0014A61K9/06A61K31/436A61K47/08A61K47/10
Inventor 徐月红王艺璇曹思思于恺悦
Owner SUN YAT SEN UNIV
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