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A liposome structure, composition and preparation method for realizing skin cleansing and anti-aging

A technology for skin cleansing and micro-lipocapsules, which is applied to skin care preparations, medical preparations containing active ingredients, and pharmaceutical formulations, etc. Wrinkles, improve skin elasticity

Active Publication Date: 2021-06-01
润芳可(上海)生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, cosmetics containing various liposomes are relatively common in developed countries, but domestic research in this area is still in its infancy, and a perfect market has not been formed.

Method used

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  • A liposome structure, composition and preparation method for realizing skin cleansing and anti-aging
  • A liposome structure, composition and preparation method for realizing skin cleansing and anti-aging
  • A liposome structure, composition and preparation method for realizing skin cleansing and anti-aging

Examples

Experimental program
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Effect test

Embodiment 1

[0028] Weigh 15 parts of lecithin and 85 parts of soybean lecithin by weight, dissolve them in a mixture of chloroform and methanol (v:v=1:1), add 30 parts of jojoba oil, 25 parts of vitamin E, 20 parts of part of superoxide dismutase and 10 parts of dipalmitoyl hydroxyproline, and the organic solvent was evaporated under reduced pressure to form a thin film. Phosphate buffer solution with a pH of 6.5 and a concentration of 8 mmol / L was added, and the solution was mechanically stirred and hydrated for 3 hours at a temperature of 50 °C to obtain a suspension, which was left to stand for 24 hours, and centrifuged to obtain liposome A. Weigh 45 parts of sphingomyelin, 15 parts of cholesterol, 15 parts of fatty acid, 15 parts of phosphatidylcholine and 10 parts of cholesterol sulfate dissolved in a mixture of chloroform and methanol (v:v=1:1) 10 parts of glutathione, 25 parts of fruit acid, 35 parts of vitamin C, 10 parts of retinol, and 5 parts of coenzyme Q10 were added, and the...

Embodiment 2

[0030]Weigh 15 parts of lecithin and 85 parts of soybean lecithin by weight, dissolve them in a mixture of chloroform and methanol (v:v=1:1), add 40 parts of jojoba oil, 30 parts of vitamin E, 30 parts of part of superoxide dismutase and 20 parts of dipalmitoyl hydroxyproline, and evaporated under reduced pressure to remove the organic solvent to form a thin film. Phosphate buffer solution with a pH of 6.5 and a concentration of 8 mmol / L was added, and the solution was mechanically stirred and hydrated for 3 hours at a temperature of 45 °C to obtain a suspension, which was left to stand for 24 hours, and centrifuged to obtain liposome A. Weigh 45 parts of sphingomyelin, 15 parts of cholesterol, 15 parts of fatty acid, 15 parts of phosphatidylcholine and 10 parts of cholesterol sulfate dissolved in chloroform and methanol (v:v=1:1). In the mixed solution, 15 parts of glutathione, 30 parts of fruit acid, 45 parts of vitamin C, 10 parts of retinol, and 10 parts of coenzyme Q10 we...

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Abstract

The present invention relates to the technical field of cosmetics, in particular to a liposome structure, composition and preparation method for skin cleaning and anti-aging, which consists of two liposomes A and B with different structures in a weight ratio of 1:1; Wherein, the liposome A is a multilayer liposome structure, which is formed by wrapping the skin cleansing composition with a wall material, and the composition of the liposome A wall material is lecithin and soybean lecithin; the liposome B is a single-layer liposome The lipid vesicle structure is formed by wrapping the skin anti-aging composition with the wall material, and the components of the liposome B wall material are sphingomyelin, cholesterol, fatty acid, phosphatidylcholine and cholesterol sulfate. The present invention adopts liposome A and microliposome B with two different particle sizes and structures to wrap the skin cleansing composition and the skin anti-aging composition respectively, and acts on the skin surface and deep layer of the skin respectively. The mutual synergy and mutual promotion can achieve significant skin cleansing and anti-aging effects.

Description

technical field [0001] The present invention relates to the technical field of cosmetics, more particularly, to a lipocapsule structure, composition and preparation method for realizing skin cleansing and anti-aging. Background technique [0002] In recent years, the cosmetics market has developed rapidly. Cosmetics refers to products that are spread on the surface of the human body such as the skin by smearing, spraying or other similar methods for the purpose of cleaning, maintenance, beauty and anti-aging, including facial cleansers, essences, masks, etc. With the improvement of people's living standards, consumers have higher and higher requirements for the efficacy of cosmetics. This enables active ingredients with high potency to be continuously discovered and used in cosmetic formulation development. There are two problems in this process that limit the effective application of many active ingredients with specific efficacy. First, many active components, such as v...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K8/14A61K8/02A61K8/92A61K8/36A61K8/365A61K8/44A61K8/55A61K8/63A61K8/64A61K8/66A61K8/67A61K8/68A61K8/35A61Q19/08A61Q19/10
CPCA61K8/025A61K8/14A61K8/355A61K8/361A61K8/365A61K8/44A61K8/553A61K8/63A61K8/64A61K8/66A61K8/671A61K8/676A61K8/678A61K8/68A61K8/922A61K2800/592A61Q19/08A61Q19/10
Inventor 高文红王伟蒋琰郑芸王一辰刘明富
Owner 润芳可(上海)生物科技有限公司
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