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Chitosan oligosaccharide, composition containing chitosan oligosaccharide, medicine or food containing chitosan oligosaccharide and application of chitosan oligosaccharide

A technology of chitosan oligosaccharide and composition, which is applied in the direction of medical preparations containing active ingredients, drug combinations, antipyretics, etc., and can solve the problems of large dosage and unclear changes

Inactive Publication Date: 2018-09-11
INST OF PROCESS ENG CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

And CN104413334A is the most relevant to the aforementioned technical problems, but chitosan oligosaccharides is not clear about the changes of intestinal bacteria, and the dosage is relatively large

Method used

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  • Chitosan oligosaccharide, composition containing chitosan oligosaccharide, medicine or food containing chitosan oligosaccharide and application of chitosan oligosaccharide
  • Chitosan oligosaccharide, composition containing chitosan oligosaccharide, medicine or food containing chitosan oligosaccharide and application of chitosan oligosaccharide
  • Chitosan oligosaccharide, composition containing chitosan oligosaccharide, medicine or food containing chitosan oligosaccharide and application of chitosan oligosaccharide

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Example 1 Oligochitosan regulates intestinal flora caused by high-fat diet

[0027] (1) In this embodiment, in order to evaluate the regulatory effect of oligochitosan on the intestinal flora of obese mice, 24 four-week-old C57BL / 6 mice were randomly divided into 4 groups, with 6 mice in each group, corresponding to Normal diet group (NCD), high-fat diet model group (HFD), normal diet and chitooligosaccharide combined group (NCD-COS), high-fat diet and chitooligosaccharide combined group (HFD-COS), etc. The mice were raised in an environment with constant temperature and humidity. After the environmental adaptation period, they were fed with corresponding normal feed or high-fat feed respectively, and water was fed with chitosan oligosaccharide 10 mg / kg. The feeding process continued for 5 months.

[0028] (2) After step (1) is completed, collect fresh feces in the large intestine of the mouse, extract the genes therein, and perform second-generation high-throughput nuc...

Embodiment 2

[0031] Example 2 Oligochitosan regulates the intestinal flora caused by diabetes

[0032] (1) In the present embodiment, in order to evaluate the regulatory effect of chitosan oligosaccharides on the intestinal flora of diabetic mice, 12 four-week-old C57BL / 6 mice and 12 four-week-old transgenic diabetic db / db mice were mouse. Randomly divided into 4 groups, 6 in each group, corresponding to normal group (WT), diabetic model group (DB), normal mice and chitosan oligosaccharide combined group (WT-COS), diabetic mice and chitosan oligosaccharide combined group ( DB-COS), etc. The mice were reared in an environment with constant temperature and humidity, and underwent an adaptation period of 1 week. Then, feed corresponding normal standard feed respectively, feed the chitosan oligosaccharide of 300mg / kg / d to water simultaneously, and feeding process continues 2 months.

[0033](2) After step (1) is completed, collect fresh feces in the large intestine of the mouse, extract the...

Embodiment 3

[0036] The proportioning method of embodiment 3 oligochitosaccharides and probiotic composition

[0037] (1) Proportion 1

[0038] The bacterial strain of Akkermansia genus Akkermansia Muciniphila was cultured through anaerobic fermentation, the thalline was collected and washed, dried at low temperature to prepare active bacterial powder, and 2 parts of chitosan oligosaccharides were added for every 1 part of Akkermansia bacterial powder. Then add conventional auxiliary materials, and make medicines or health care products through conventional processes.

[0039] (2) Proportion 2

[0040] The classic strains of the Bifidobacterium genus are continuously cultured in liquid, the cells are collected and washed, dried at low temperature to prepare active bacterial powder, and 1 part of chitosan oligosaccharide is added for every part of Bifidobacterium bacterial powder. Then add conventional auxiliary materials, and make medicine or health care products through conventional pro...

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Abstract

The invention discloses application of chitosan oligosaccharide as regulating agent for regulating animal intestinal flora disturbance, the chitosan oligosaccharide, a mixture containing the chitosanoligosaccharide and corresponding application. The polymerization degree of the chitosan oligosaccharide is 2 to 20, so that the intestinal flora disturbance caused by obesity or diabetes or an unreasonable diet structure can be regulated, growth of beneficial bacteria such as Akkermansia, Bifidobacterium and Lactobacillus of an intestinal tract is promoted, and proliferation of harmful bacteriasuch as Desulfovibrio and Helicobacter is obviously inhibited. The invention provides an application method of a clinically-acceptable medicinal preparation or health-care food which is made by usingthe chitosan oligosaccharide alone or a composition prepared from the chitosan oligosaccharide and the beneficial bacteria according to a conventional process. By utilizing the chitosan oligosaccharide, prevention and control of the intestinal disturbance caused by the diabetes, the obesity and the inflammatory bowel disease have an active application value.

Description

technical field [0001] The invention belongs to the field of health food and functional food, and in particular relates to oligochitosan, a composition containing oligochitosan, medicine or food containing oligochitosan and the application of oligochitosan. Background technique [0002] The human intestinal tract nourishes tens of billions of bacteria. The rich nutrition in the intestinal tract maintains a large bacterial community of various types and activities, forming an extremely complex super ecosystem with the host. Studies have shown that the intestinal flora has been in dynamic changes, and the host's food, health status, drug use, genetic background, etc. can significantly affect the composition and abundance of the intestinal flora. Evidence shows that under most disease conditions, the intestinal flora is in a disordered state, the content of harmful bacteria increases and the abundance of beneficial bacteria decreases, and changing the composition of intestinal ...

Claims

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Application Information

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IPC IPC(8): A61K31/722A61K31/702A61P3/04A61P1/00A61P29/00A61P3/10A23L33/125
Inventor 杜昱光郑军平刘洪涛程功张琛
Owner INST OF PROCESS ENG CHINESE ACAD OF SCI
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