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Application of N-acetylcysteine and composition containing N-acetylcysteine

A technology of acetylcysteine ​​and a composition, which is applied to the field of compositions containing N-acetylcysteine, can solve problems such as unclear action mechanism, and achieves improvement of intestinal flora disorder, content reduction, internal Toxin reduction effect

Inactive Publication Date: 2018-07-20
INST OF PROCESS ENG CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the structure of N-acetyl cysteine ​​is not exactly the same as that of N-acetyl cysteine ​​amide. Related literature has proved that N-acetyl cysteine ​​can improve glucose and lipid metabolism disorders caused by high-fat diets, However, the mechanism of action is not clear

Method used

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  • Application of N-acetylcysteine and composition containing N-acetylcysteine
  • Application of N-acetylcysteine and composition containing N-acetylcysteine
  • Application of N-acetylcysteine and composition containing N-acetylcysteine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Example 1 N-acetylcysteine ​​regulates intestinal flora caused by high-fat diet

[0021] (1) In this embodiment, in order to evaluate the regulatory effect of N-acetylcysteine ​​on the intestinal flora of obese mice, 24 four-week-old C57BL / 6 mice were randomly divided into 4 groups, each with 6 Only, corresponding to normal diet group (NCD), high-fat diet model group (HFD), normal diet and N-acetylcysteine ​​combination group (NCD-NAC), high-fat diet and N-acetylcysteine ​​combination group group (HFD-NAC), etc. The mice were raised in an environment with constant temperature and humidity. After the environmental adaptation period, they were fed with the corresponding normal feed or high-fat feed, and at the same time fed with water at a dose of 100 mg / kg of N-acetylcysteine. The feeding process lasted for 5 days. moon.

[0022] (2) After step (1) is completed, collect fresh feces in the large intestine of the mouse, extract the genes therein, and perform second-gener...

Embodiment 2

[0028] Example 2 N-acetylcysteine ​​regulates intestinal flora caused by diabetes

[0029] (1) In this example, in order to evaluate the regulatory effect of N-acetylcysteine ​​on the intestinal flora of diabetic mice, 12 four-week-old C57BL / 6 mice and 12 four-week-old transgenic diabetic db / db mice. They were randomly divided into 4 groups with 6 rats in each group, corresponding to normal group (WT), diabetic model group (DB), normal mice and N-acetylcysteine ​​combined group (WT-NAC), diabetic mice and N- Acetylcysteine ​​combination group (DB-NAC) and so on. The mice were reared in an environment with constant temperature and humidity, and underwent an adaptation period of 1 week. Then, the corresponding normal standard feed was fed respectively, and 300 mg / kg / d N-acetylcysteine ​​was fed to the water at the same time, and the feeding process lasted for 2 months.

[0030] (2) After step (1) is completed, collect fresh feces in the large intestine of the mouse, extract t...

Embodiment 3

[0036] The application method of embodiment 3N-acetylcysteine

[0037] (1) Capsules

[0038] a. Take a certain amount of N-acetylcysteine ​​dry powder and dissolve it in water to obtain an N-acetylcysteine ​​solution;

[0039] b. Add an appropriate amount of conventional auxiliary materials to the N-acetylcysteine ​​solution described in step a and mix evenly;

[0040] c. freeze-drying the homogeneously mixed material obtained in step b, and pulverizing;

[0041] d. Fill the crushed granules obtained in step c into capsules according to a certain mass, and pack them separately to obtain final product.

[0042] (2) Tablets

[0043] a. Take a certain amount of dry N-acetylcysteine ​​powder and dissolve it in water to form an N-acetylcysteine ​​solution;

[0044] b. Add an appropriate amount of conventional auxiliary materials to the N-acetylcysteine ​​solution obtained in step a, and mix evenly;

[0045] c. The homogeneous mixed solution obtained in step a is made into gran...

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Abstract

The invention discloses application of N-acetylcysteine to preparation of a regulator for animal intestinal flora disturbance as well as a composition containing the N-acetylcysteine. The regulator isa clinically acceptable medicinal preparation or health-care food, wherein the clinically acceptable preparations or health-care food is capsules, tablets, pills, granules, oral liquid, syrup, electuary, dropping pills, powder, injection, medicinal tea, soft capsules, solid beverage, sustained-release preparations, beverage or baked food. The experimental result indicates that the N-acetylcysteine has a good effect of relieving intestinal flora disturbance caused by obesity or diabetes or inflammatory bowel diseases or high calorie diet, and can be further applied to development and application of the medicinal preparations or health-care food.

Description

technical field [0001] The invention belongs to the field of medicine and health food, and specifically relates to the use of N-acetylcysteine ​​for preparing an animal intestinal flora disorder regulator and a composition containing N-acetylcysteine. Background technique [0002] The intestinal flora that reproduces in the host's gut is not a simple parasitic relationship with the host, but a mutually beneficial symbiotic relationship. Gut flora can affect the health of the host and perform three important functions: metabolic functions, such as the uptake and transformation of fatty acids and amino acids; protective functions, such as reducing the absorption of host fatty acids and reducing the invasion of other harmful bacteria or pathogenic sources; Structural function, regulating host immune function and intestinal barrier function. Due to differences in dietary ingredients, genetic background, work and rest habits, living environment, drug stimulation, etc., the compo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/198A23L33/175A61P3/10A61P3/04A61P29/00A61P1/00
Inventor 杜昱光郑军平刘洪涛冯翠原旭冰
Owner INST OF PROCESS ENG CHINESE ACAD OF SCI
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