Check patentability & draft patents in minutes with Patsnap Eureka AI!

Celecoxib pharmaceutical composition and preparation method thereof

A technology of celecoxib and its composition, which is applied in the field of celecoxib pharmaceutical composition and its preparation, and can solve problems such as poor processability

Active Publication Date: 2018-09-14
北京德立赛纳医药科技有限公司
View PDF26 Cites 5 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The pharmaceutical composition greatly improves the dissolution rate of the celecoxib preparation in an acidic medium, improves the oral absorption characteristics of the celecoxib preparation, overcomes the disadvantage of poor processability of the celecoxib preparation, and can be industrially produced

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Celecoxib pharmaceutical composition and preparation method thereof
  • Celecoxib pharmaceutical composition and preparation method thereof
  • Celecoxib pharmaceutical composition and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0090] Example 1 - preparation of celecoxib dispersion (celecoxib: insoluble dispersant: weight ratio of bioadhesive material=1:2:1)

[0091] Weigh 5 g of celecoxib and dissolve it in 1 L of ethanol to form a homogeneous clear solution. Add 10g SYSLSIA350FCP and stir well. add 5g L100-55, stir until dissolved. Vacuum-dry at 50° C. for 3 h under a pressure of -0.09 MPa in a rotary evaporator to evaporate ethanol, form a white solid, pulverize, and pass through a 60-mesh sieve to obtain a celecoxib dispersion.

Embodiment 2

[0092] Example 2 - Preparation of celecoxib dispersion (celecoxib: insoluble dispersant: weight ratio of bioadhesive material=1:2:2)

[0093] Weigh 5 g of celecoxib and dissolve it in 1 L of ethanol to form a homogeneous clear solution. Add 10g SYSLSIA350FCP and stir well. add 10g L100-55, stir until dissolved. In a rotary evaporator at 50° C. for 3 h under a pressure of -0.09 MPa to evaporate ethanol, a white solid was formed, which was pulverized and passed through a 60-mesh sieve to obtain a celecoxib dispersion.

Embodiment 3

[0094] Example 3 - Preparation of celecoxib dispersion (celecoxib: insoluble dispersant: weight ratio of bioadhesive material=1:2:3)

[0095] Weigh 5 g of celecoxib and dissolve it in 1 L of ethanol to form a homogeneous clear solution. Add 10g SYSLSIA350FCP and stir well. Add 15g L100-55, stir until dissolved. In a rotary evaporator at 50° C. for 3 h under a pressure of -0.09 MPa to evaporate ethanol, a white solid was formed, which was pulverized and passed through a 60-mesh sieve to obtain a celecoxib dispersion.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
Solubilityaaaaaaaaaa
Solubilityaaaaaaaaaa
Login to View More

Abstract

The invention relates to a celecoxib pharmaceutical composition and a preparation method of the celecoxib pharmaceutical composition and preparation method. More specifically, the invention belongs tothe field of pharmaceutic preparations. The celecoxib pharmaceutical composition comprises a solid dispersing body and optionally comprises pharmaceutically acceptable ingredients and a crystallization inhibitor, the solid dispersing body comprises celecoxib, an insoluble dispersing agent and a biological adhesive material. The pharmaceutical composition is absorbed rapidly after being orally taken, and the effective blood concentration is reached at the low dosage.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, and in particular relates to a Celecoxib pharmaceutical composition and a preparation method thereof. Background technique [0002] Non-steroidal anti-inflammatory drugs (NSAIDs) are the most widely used and oldest (more than 100 years old) prescription drugs in the world. More than 30 million people take them every day. , Anti-inflammatory, anti-rheumatic drugs. The main mechanism of its action is to inhibit the cyclooxygenase (cycloxygenase, COX) in the body, thereby reducing the synthesis of prostaglandins that cause fever, swelling and pain sensitization. Celecoxib is a new generation of NSAIDs with the following structure: [0003] [0004] It has a unique mechanism of action, that is, it specifically inhibits cyclooxygenase-2 (COX-2). Inflammatory stimulation can induce the production of COX-2, which leads to the synthesis and accumulation of inflammatory prostaglandins, esp...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K31/635A61K9/14A61K47/04A61P29/00
CPCA61K9/146A61K31/635A61K47/02
Inventor 吴翠栓王小旭商丹丹林琳谢贺贺刘宇飞张强马凤中
Owner 北京德立赛纳医药科技有限公司
Features
  • R&D
  • Intellectual Property
  • Life Sciences
  • Materials
  • Tech Scout
Why Patsnap Eureka
  • Unparalleled Data Quality
  • Higher Quality Content
  • 60% Fewer Hallucinations
Social media
Patsnap Eureka Blog
Learn More

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2025 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com