Sinomenine hydrochloride sustained-released injection and preparation method thereof

A technology of sinomenine hydrochloride and slow-release injections, which is applied in anti-inflammatory agents, pharmaceutical formulas, non-central analgesics, etc., and can solve the problems of large side effects and frequent use

Inactive Publication Date: 2009-04-01
HUNAN ZHENGQING PHARM GRP CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, sinomenine hydrochloride is mainly used as an injection for clinical treatment. Although sinomenine hydrochloride injection has a definite curative effect, it has the disadvantages of frequent use (injection once a day) and large side effects in clinical practice.

Method used

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  • Sinomenine hydrochloride sustained-released injection and preparation method thereof
  • Sinomenine hydrochloride sustained-released injection and preparation method thereof
  • Sinomenine hydrochloride sustained-released injection and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0059] Dissolve 10Kg of sinomenine hydrochloride in 0.2KL of water as the internal water phase, and dissolve 100Kg of lactide-glycolide copolymer 50 / 50 or lactide-glycolide copolymer 75 / 25 in 5KL of ethyl acetate as the organic phase, add the inner water phase to the outer water phase, and form water / oil type colostrum by high-speed shearing; add the formed colostrum drop by drop into 20KL aqueous solution containing 1% polyvinyl alcohol, and form water / oil type by high-speed shearing / water-type double emulsion; add this double emulsion to 100KL0.1% polyvinyl alcohol aqueous solution, stir magnetically at room temperature for 20 minutes, evaporate under reduced pressure to remove the organic solvent, centrifuge, wash with water, and dry to obtain synthetic polymer nanoparticles .

Embodiment 2

[0061] Dissolve 15Kg of sinomenine hydrochloride in 0.1KL of water as the internal water phase, and dissolve 140Kg of lactide-glycolide copolymer 50 / 50 or lactide-glycolide copolymer 75 / 25 in 4KL of ethyl acetate as the organic phase, add the inner water phase to the outer water phase, and form water / oil type colostrum by high-speed shearing; add the formed colostrum drop by drop into 30KL aqueous solution containing 0.5% polyvinyl alcohol, and form water / oil type by high-speed shearing / water-type double emulsion; add this double emulsion to 140KL0.08% polyvinyl alcohol aqueous solution, stir magnetically at room temperature for 25 minutes, evaporate under reduced pressure to remove the organic solvent, centrifuge, wash with water, and dry to obtain synthetic polymer nanoparticles .

Embodiment 3

[0063] Dissolve 8Kg of sinomenine hydrochloride in 0.3KL of water as the internal water phase, and dissolve 90Kg of lactide-glycolide copolymer 50 / 50 or lactide-glycolide copolymer 75 / 25 in 7KL of ethyl acetate as the organic phase, add the inner water phase to the outer water phase, and form water / oil type colostrum by high-speed shearing; add the formed colostrum drop by drop to 10KL aqueous solution containing 1.5% polyvinyl alcohol, and form water / oil type by high-speed shearing / water-type double emulsion; add this double emulsion to 90KL0.15% polyvinyl alcohol aqueous solution, stir magnetically at room temperature for 15 minutes, then evaporate under reduced pressure to remove the organic solvent, centrifuge, wash with water, and dry to obtain synthetic polymer nanoparticles .

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PUM

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Abstract

The invention discloses a sinomenine hydrochloride sustained release injection and a preparation method thereof. The sustained release injection comprises one of synthetic polymer nanometer sinomenine hydrochloride sustained release injection, natural polymer material microsphere sinomenine hydrochloride sustained release injection, lipid sinomenine hydrochloride sustained release injection, multivesicular liposome sinomenine hydrochloride sustained release injection and gelatin sinomenine hydrochloride sustained release injection. Various sinomenine hydrochloride sustained release injections prepared by the invention by different methods can prolong the acting time of drug, reduce drug administration times, keep stable blood concentration in vivo and reduce the toxic and side effects of the drug.

Description

technical field [0001] The invention relates to a new pharmaceutical dosage form of sinomenine hydrochloride, in particular to a sinomenine hydrochloride sustained-release injection and a preparation method thereof. Background technique [0002] Sinomenine is an active ingredient extracted from the traditional Chinese medicine Qingfengteng. It is an effective Chinese medicine for treating rheumatism and rheumatoid arthritis. Its hydrochloride is often used in medicine. This variety has remarkable curative effect and good market promotion, and has now become a commonly used drug. At present, sinomenine hydrochloride is mainly used as an injection for clinical treatment. Although sinomenine hydrochloride injection has a definite curative effect, it has disadvantages such as frequent use (injection once a day) and large side effects in clinical practice. Contents of the invention [0003] One object of the present invention is to disclose a new drug dosage form of sinomenine...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/127A61K9/08A61K31/485A61K9/00A61P29/00A61P19/02A61P19/04
Inventor 奉建芳吴飞驰邹凌燕仇萍滕健
Owner HUNAN ZHENGQING PHARM GRP CO LTD
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