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Strong medicine composition for treating chronic granulocytic leukemia and preparation thereof

A technology for chronic myeloid cells and leukemia, applied in the field of medicine, can solve the problems of side effects, high price, unsuitable for long-term use, etc., and achieve the effects of safe and reliable administration, prevention and treatment of drug resistance, and avoidance of toxic and side effects.

Inactive Publication Date: 2018-09-14
广西忠宁制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The current medicines for the treatment of chronic myelogenous leukemia are expensive and have side effects and are not suitable for long-term use

Method used

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  • Strong medicine composition for treating chronic granulocytic leukemia and preparation thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0052] Example 1 tablet

[0053] Weigh 1000g of Radix Isatidis and 1500g of Folium Isatidis, add water to extract 2 times after mixing, the amount of water added each time is equivalent to 12 times and 10 times the total weight of medicinal materials, and the two extraction times are 3 hours and 2 hours respectively, and the extracts are combined. Filtrate, concentrate the clear paste with a relative density of 1.10 when the filtrate is concentrated at 70° C., add tablet auxiliary materials microcrystalline cellulose, gelatin, magnesium stearate, polyethylene glycol to the clear paste, and make tablets according to a conventional scheme.

Embodiment 2

[0054] Example 2 tablet

[0055] Weigh 1500g of Radix Isatidis and 2250g of Folium Isatidis, mix and extract twice with 50% ethanol under reflux, each time the amount of ethanol is 8 times and 6 times of the total weight of the medicinal materials, and the extraction time is 1.5 hours and 1 hour respectively. Combine the extracts, filter, and concentrate the filtrate to a clear paste with a relative density of 1.25 when the filtrate is concentrated to 60° C., add tablet adjuvant starch to the clear paste, mix, granulate, and dry to make 1000 tablets of the present invention.

Embodiment 3

[0056] Embodiment 3 capsules

[0057] Weigh 1100g of Radix Isatidis and 1650g of Folium Isatidis, add water to extract 2 times after mixing, the amount of water added each time is equivalent to 12 times and 8 times of the total weight of medicinal materials, and the extraction time is 3 hours and 2 hours respectively, and the extracts are combined. Filter, when the filtrate is concentrated to 70°C, the relative density is 1.10, add ethanol, make the alcohol content 40%, let it stand for 12 hours, filter, when the filtrate is concentrated to 70°C, the relative density is 1.05 Add capsule auxiliary materials powdered sugar, cellulose derivatives, crospovidone and ethanol to the ointment, and prepare capsules according to a conventional scheme.

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Abstract

The invention discloses a strong medicine composition for treating chronic granulocytic leukemia and preparation thereof. The strong medicine composition and the preparation thereof are simple in formula, safe and mild; by combining cusiae and folium isatidis, the functions of clearing away heat and toxic materials, cooling and activating blood, removing stasis, dispersing blood stasis, strengthening the body resistance to eliminate pathogenic factors, protecting visceral organs, regulating qi and blood and enhancing immunity are achieved, the effect of promoting recovery of the normal marrowhematopoietic function is achieved, the effective component indirubin extracted from cusiae and folium isatidis has the obvious killing effect on leukemia cells, and the effect of promoting T lymphocyte proliferation is achieved; in addition, the strong medicine composition is scientific and reasonable in formula, the side effects are small, the preparation method is simple, the preparation cost is low, the composition becomes effective rapidly, the chronic granulocytic leukemia does not relapse almost, no bone marrow transplantation needs to be performed during chronic granulocytic leukemia treatment, little pain is caused to a patient, the patient accepts the composition easily, the body and economic burdens can be greatly relieved, and the great popularization value is achieved.

Description

technical field [0001] The invention relates to the field of medicine, in particular to a strong medicinal composition for treating chronic myeloid leukemia and its preparation. Background technique [0002] Chronic myelogenous leukemia, referred to as CML, is a cell line disease caused by malignant transformation at the level of pluripotent stem cells with acquired chromosomal abnormalities. It is a relatively common type of leukemia, accounting for about 15% of leukemia cases in my country. %-25%, second only to acute myeloid leukemia and acute lymphoblastic leukemia, ranking third. Its etiology has not been fully understood so far, and it is a multifactorial disease such as physics, chemistry, and genetics. 75-85% of chronic myeloid changes from stable phase to blast phase within 1-5 years. Once the slow myeloid changes abruptly, the prognosis is poor. More than half of the cases die within 3-6 months, and only a few cases can last more than 1 year. [0003] The Zhuang p...

Claims

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Application Information

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IPC IPC(8): A61K36/315A61P35/02
CPCA61K36/195A61K36/315A61K2236/331A61K2236/333A61K2236/39A61P35/02A61K2300/00
Inventor 刘元何其忠覃红放张颖吴鹏
Owner 广西忠宁制药有限公司
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