The invention discloses a strong medicine composition for treating chronic granulocytic leukemia and preparation thereof. The strong medicine composition and the preparation thereof are simple in formula, safe and mild; by combining cusiae and folium isatidis, the functions of clearing away heat and toxic materials, cooling and activating blood, removing stasis, dispersing blood stasis, strengthening the body resistance to eliminate pathogenic factors, protecting visceral organs, regulating qi and blood and enhancing immunity are achieved, the effect of promoting recovery of the normal marrowhematopoietic function is achieved, the effective component indirubin extracted from cusiae and folium isatidis has the obvious killing effect on leukemia cells, and the effect of promoting T lymphocyte proliferation is achieved; in addition, the strong medicine composition is scientific and reasonable in formula, the side effects are small, the preparation method is simple, the preparation cost is low, the composition becomes effective rapidly, the chronic granulocytic leukemia does not relapse almost, no bone marrow transplantation needs to be performed during chronic granulocytic leukemia treatment, little pain is caused to a patient, the patient accepts the composition easily, the body and economic burdens can be greatly relieved, and the great popularization value is achieved.