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Medicine composition used for preventing and/or treating neurodegenerative diseases and preparation method and application thereof

A neurodegenerative and composition technology, used in drug combinations, nervous system diseases, pharmaceutical formulations, etc., can solve problems such as high fatality rate, affecting patients' cognitive and motor functions, and disability, and achieve good therapeutic effects and good health. Therapeutic effect, convenient use effect

Inactive Publication Date: 2018-09-28
CHENGDU UNIV OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

These diseases affect the cognitive and motor functions of patients, causing disability and high mortality, and bring huge psychological and economic burdens to patients' families and society.
For most neurodegenerative diseases, there is no cure for the disease that can effectively block the degeneration process of nerve cells. Clinically, drugs are mainly used for symptomatic treatment, which can only improve symptoms

Method used

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  • Medicine composition used for preventing and/or treating neurodegenerative diseases and preparation method and application thereof
  • Medicine composition used for preventing and/or treating neurodegenerative diseases and preparation method and application thereof
  • Medicine composition used for preventing and/or treating neurodegenerative diseases and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Weigh 10 g of chlorogenic acid and 50 g of evodiamine and mix them evenly.

Embodiment 2

[0023] Weigh 100 g of chlorogenic acid, 10 g of evodiamine, add 140 g of excipient starch to granulate, 5 g of magnesium stearate, 150 g of dextrin, and 150 g of microcrystalline cellulose, uniformly prepare granules, and press into tablets to obtain tablets.

Embodiment 3

[0025] Weigh 50 g of chlorogenic acid and 10 g of evodiamine, add 75 g of excipients starch, 3 g of magnesium stearate, 80 g of dextrin, and 80 g of microcrystalline cellulose to uniformly prepare granules, and press into tablets to obtain tablets.

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PUM

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Abstract

The invention discloses a medicine composition used for preventing and / or treating neurodegenerative diseases. The medicine composition is prepared from, by weight, 1-10 parts of chlorogenic acid and1-10 parts of evodiamine. The experiment result shows that compatibility of the chlorogenic acid and evodiamine has a synergistic interaction effect.

Description

technical field [0001] The present invention relates to a pharmaceutical composition for preventing and / or treating neurodegenerative diseases and its preparation method and use. Background technique [0002] Neurodegenerative diseases are diseases caused by the decline of central nervous system function caused by progressive degeneration and necrosis of nerve cells, which are aggravating with the aging of the global population, including Alzheimer's disease (AD), Parkinson's disease (Parkinson's disease, PD), amyotrophic lateral sclerosis (Atrophy lateralsclerosis, ALS) and multiple sclerosis (Multiple Sclerosis, MS) and so on. These diseases affect the cognitive and motor functions of patients, with high disability and fatality rates, and bring huge psychological and economic burdens to the patient's family and society. For most neurodegenerative diseases, there is no cure for effectively blocking the degeneration process of nerve cells. Clinically, drugs are mainly used ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/519A61K31/216A61P25/00A61P25/28
CPCA61K31/519A61K31/216A61P25/00A61P25/28A61K2300/00
Inventor 徐世军文跃强王平代渊魏江平付颖陈欢郑航
Owner CHENGDU UNIV OF TRADITIONAL CHINESE MEDICINE