40results about How to "Less prone to tolerance" patented technology

The invention synthesizes four novel endomorphin-1 analogs, and belongs to the technical field of biochemistry. The endomorphin-1 analogs are prepared by performing N-end guanidyl formation at the first-position Tyr of endomorphin-1, replacing the second-position Pro by D-Ala, replacing the third-position Trp by Gly, and replacing the fourth-position Phe by Trp or performing para-position chlorination and fluorination modification or no modification on a benzene ring of Phe. The synthesized endomorphin-1 analogs are subjected to a series of physiological and pharmacological activity identification such as radio-ligand receptor binding assays, isolated organ bioactivity identification experiments, isolated enzymolysis stability experiments, analgesic tests with water bath and medicine tolerance experiments, show high affinity activity, high enzymolysis stability and high analgesic activity, and hardly cause tolerance. Therefore, the four novel endomorphin-1 analogs can be used for preparing clinical analgesic medicines.

The present invention relates to a cervical and lumbar treatment instrument and a preparation method, including an outer shell which contacts with the human body directly and a heating element which is arranged in the outer shell; the present invention is characterized in that the outer shell is made of bamboo which is scrapped off the outer layer, furthermore, the bamboo experiences the soaking and boiling process with two different traditional Chinese medicine liquid, wherein, a first traditional Chinese medicine liquid is prepared by the raw materials with the following mix ratio by weight: 50 parts of water, 0.8 to 1.2 parts of vitex negundo, 0.7 to 0.95 part of Indian stringbush root and 0.8 to 1.0 part of eucommia ulmoides oliver; a second traditional Chinese medicine liquid is prepared by the raw materials with the following mix ratio by weight: 50 parts of water, 0.8 to 1.2 parts of vitex negundo, 0.7 to 0.95 part of Indian stringbush root and 0.8 to 1.0 part of gardenia jasminoides ellis. The preparation method includes selection of bamboo blocks, soaking and boiling of the bamboo blocks, softening process, drying in the shade, soaking and boiling process of the first traditional Chinese medicine liquid, soaking and boiling process of the second traditional Chinese medicine liquid, assembly and other steps. The treatment instrument has significant alleviating effect of the short-term symptoms of cervical, lumbar and back diseases and pains, furthermore, the present invention can obtain the consolidated and sustained effect after a longer period of the treatment, at the same time, the present invention is also characterized in that the present invention is not easy to generate the tolerance. The preparation method is characterized by simple property, easy obtaining of the materials, low production cost and natural environmental protection.

The invention discloses toothpaste for relieving tooth sensitivity. The toothpaste is prepared from the following raw materials in parts by weight: 70-80 parts of calcium hydrogen phosphate, 30-35 parts of sorbitol, 18-22 parts of glycerol, 2-5 parts of sodium laurylsulfate, 1-2 parts of hydroxypropyl methylcellulose, 3-6 parts of guar gum, 0.5-1.0 part of potassium sorbate, 1.2-1.7 parts of stevioside, 12-16 parts of hawthorn leaf extract, 3-7 parts of edible tulip extract and 6-10 parts of allium macrostemon extract. The invention also discloses a preparation method of the toothpaste for relieving tooth sensitivity. The toothpaste prepared by the preparation method disclosed by the invention can relieve tooth sensitivity, has an obvious effect, adopts Chinese herbal medicinal ingredients, and does not contain fluoride, so that the toothpaste is easier to accept by masses of consumers, and has a broad market prospect.

The invention relates to an efficient compound medicine resisting skin aging and a preparation method thereof. The efficient compound medicine resisting skin aging is prepared from the following various ingredients in proportion by mass: 0.01-0.1% of retinoic acid, 1-5% of glucosamine hydrochloride or N-acetyl glucosamine and the balance of a cream matrix. The preparation method comprises the following steps: adequately dissolving retinoic acid and glucosamine hydrochloride or N-acetyl glucosamine with the proportions in a corresponding amount of polyethylene glycol and mixing by a container; then mixing the mixture with the cream matrix, and stirring for 30 seconds by a superfine homogenizer to obtain the product. According to the preparation method disclosed by the invention, the dosage of retinoic acid is reduced by virtue of the synergistic effect between retinoic acid and glucosamine hydrochloride or N-acetyl glucosamine, and the functions of moisturizing and improving skin elasticity of retinoic acid are improved while skin irritation and adverse reactions are reduced. The efficient compound medicine resisting skin aging disclosed by the invention is simple in formula and convenient to use, and has the good effects of resisting skin aging, resisting wrinkles, resisting inflammation and fading spots.

The invention relates to an apparatus for treating cervical vertebra and lumbar vertebra and a preparation method thereof. The apparatus comprises a housing in direct contact with human body and a heating unit arranged inside the housing, and the apparatus is characterized in that the housing is made of Mao bamboo of which the external green peel is removed and which is subject to digestion treatment of a Chinese traditional medicine liquid made from the following raw materials by weight: 1g of negundo chastetree bud, 0.75kg of Indian stringbush root and 50kg of water. The preparation method comprises steps of selecting bamboo blocks, digestion and softening treatment of the bamboo blocks, drying in the shade, digestion treatment by the Chinese traditional medicine liquid, assembling and the like. The apparatus has significant short-term remission effects on pains of cervical vertebra, lumbar vertebra and back, and solidified and durative treatment effect can be obtained by a longer period of treatment, and at the same time the apparatus is characterized by being not easy to cause tolerance. The preparation method is characterized by simpleness, easy materials, low manufacturing cost, and natural environment protection.

The invention discloses a dysmenorrhea patch, belonging to the technical field of traditional Chinese medicine formula. Dysmenorrhea patch of the invention is composed of the following raw material inparts by weight: angelica sinensis 6-10 part, szechwan lovage rhizome of 10-20 parts, rhizoma Cyperi 10-15 parts, rhizoma corydalis 15-30 parts, trogopterus 10-20 parts, folium Artemisiae Argyi 10-15parts, folium Artemisiae Argyi 10-15 part, ramulus Cinnamomi 10-15 part, evodia rutaecarpa 10-15 part, aconite root 10-15 parts, fennel 10-15 part, eucommia ulmoides 10-15 parts,eucommia ulmoides 10-15 part; a Chinese medicinal preparation is prepared by weighing Chinese-medicinal material according to corresponding proportions, pulverize, sieving with 200 mesh sieve, and uniformly mixing; then,the mixture of the mixed Chinese herbal powders was mixed with vaseline and made into 10g pills, which were sealed and stored. The dysmenorrhea patch of the invention has obvious therapeutic effect, small side effect of medicine on human body, is not easy to produce tolerance and has long curative effect.

The invention discloses a medicine composition for treating a digestive system disease, and a preparation method and use of the medicine composition. The medicine composition is prepared from the following ingredients in parts by weight: 5-20 parts of attractylone, and 5-20 parts of magnolol. The medicine composition disclosed by the invention is prepared from the effective parts of natural medicine raw materials in combination; the medicine composition does not need to be decocted for taking, is good in curative effect, free from toxic and side effects, not easy to produce tolerance, can be prepared into a tablet, a capsule, a pill, a granule, an oral liquid and the like, and has the advantages of portability, easy taking and the like; all the medicines are nontoxic and harmless before and after the extraction; when the medicine composition is taken at normal dosage, no toxic effect and no side effect are found; and the medicine composition is widely applicable to the patients suffering from digestive system diseases.

The invention provides a bacteriostatic agent and a preparation method thereof. The bacteriostatic agent is prepared from the following raw materials in parts by weight: 10 to 20 parts of radix ophiopogonis extract, 6 to 10 parts of radix rubiae extract, 4 to 8 parts of radix polygoni multiflori extract, 10 to 20 parts of flos chrysanthemi extract and 5 to 7 parts of rhizoma polygoni cuspidati extract. Compared with the prior art, a composition provided by the invention can be dissolved as required by using water or ethanol to be used in a cleaning product, a bactericidal washing agent and thelike. The bacteriostatic agent has a good sterilization effect, and does not have a side effect; a bacterium and a fungus difficultly generate tolerance. Moreover, the preparation method is simple; ause level is small. A bacteriostatic rate to multiple bacterial virus reaches 99 percent or above, and the bacteriostatic effect is obvious.

The invention provides a medicinal composition containing bilobalide B. The medicinal composition contains bilobalide B and a vitamin K antagonist. The invention further provides a preparation method and an application of the medicinal composition. The experiment proves that bilobalide B can obviously promote the anti-platelet aggregation function of warfarin, also can eliminate/reduce the natural drug resistance of a patient generated due to only use of warfarin, and enhance the affinity between the liver receptor of a patient and warfarin, and bilobalide B and warfarin have the synergistic interaction. The medicinal composition is novel in formula, simple in components, definite in action mechanism and obvious in curative effect, tolerance is difficultly generated, and industrial production can be realized.

The invention particularly relates to an antibacterial and anti-loosening coating for a titanium and titanium alloy implant material. A preparation method of the antibacterial and anti-loosening coating comprises the following steps: 1) preparing polyethyleneimine azodiol enonium salt (BPEI-NONOates) as an NO donor material by taking branched chain polyethyleneimine (BPEI) and nitric oxide (NO) as raw materials; according to the method, gelatin and NO donor substances are used for modifying a titanium metal material, the material is endowed with the continuous antibacterial effect by prolonging the release time of NO, and the problems that titanium and titanium alloy implants are prone to infection and looseness in vivo are solved.