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Dehydroandrographolide succinate eye drops and preparation method and application thereof

An eye drop, Yanhuning technology, applied in the field of pharmaceutical preparations, can solve problems such as poor stability and large differences in efficacy, and achieve the effects of less tolerance, no toxic side effects, and increased viscosity

Inactive Publication Date: 2014-10-29
SICHUAN HETAI SYNLIGHT BIOTECH LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the main drug of Yanhuning’s preparations on the market is mainly powder injections, and eye drops only appear in some hospital preparations. Due to the different excipients and preparation processes used, the curative effect varies greatly and the stability is poor.

Method used

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  • Dehydroandrographolide succinate eye drops and preparation method and application thereof
  • Dehydroandrographolide succinate eye drops and preparation method and application thereof
  • Dehydroandrographolide succinate eye drops and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] A Yanhuning eye drop, the eye drops are composed of the following components per 100ml: Yanhuning 100mg, sodium chloride: 100mg, methylparaben: 10mg, propylparaben: 5mg, EDTA -2Na: 100 mg, the rest is buffer.

Embodiment 2

[0037] A kind of Yanhuning eye drops, which consists of the following components per 100ml: Yanhuning 500mg, sodium chloride: 300mg, methylparaben: 30mg, propylparaben: 20mg, EDTA -2Na: 300 mg, the rest is buffer.

Embodiment 3

[0039] A Yanhuning eye drop, the eye drops are composed of the following components per 100ml: Yanhuning 1000mg, sodium chloride: 500mg, methylparaben: 50mg, propylparaben: 30mg, EDTA -2Na: 500 mg, the rest is buffer.

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Abstract

The invention discloses dehydroandrographolide succinate eye drops. Every 100ml of the eye drops consists of the following components: 100-1000mg of dehydroandrographolide succinate, 100-500mg of sodium chloride, 10-50mg of methylparaben, 5-30mg of propylparaben, 100-500mg of EDTA-2Na and the balance of buffer solution. Meanwhile, the invention also discloses a specific preparation method of the eye drops. The eye drops have the advantages of good curative effect, zero toxic or side effect, small possibility of generating tolerance, convenience in use and universal applicability for patients suffering from infectious keratopathy. The experiment proves that due to the formula, the quality guarantee period of the eye drops in the invention can be obviously prolonged by selecting a specific dose of water-soluble medicinal auxiliary materials such as the sodium chloride, methylparaben, propylparaben, EDTA-2Na and buffer solution, and the stability of the product is improved.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical preparations, and relates to an eye drop, in particular to a Yanhuning eye drop, its preparation method and application. Background technique [0002] Eye drops are one of the most commonly used drug dosage forms for ophthalmic diseases, and have direct and quick therapeutic effects on many eye diseases. Although eye drops are external preparations, their quality requirements are similar to those of injections, and they have certain requirements on pH value, osmotic pressure, sterility, visible foreign matter, viscosity, etc. Among them, the pH value has an important impact on eye drops. Improper pH value can cause irritation, increase tear secretion, lead to rapid loss of drugs, and even damage the cornea. The tolerable pH range of normal eyes is 5.0-9.0, and the osmotic pressure should be consistent with tear fluid. [0003] Yanhuning is a modified product of andrographolide, and its ch...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/08A61K31/365A61P27/02A61P31/22A61P31/02
Inventor 杜彦军曾大富莫春雷黄依娟
Owner SICHUAN HETAI SYNLIGHT BIOTECH LTD
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