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A pharmaceutical composition for treating digestive system diseases, its preparation method and application

A digestive system disease and composition technology, which are applied in the field of pharmaceutical compositions for treating digestive system diseases and their preparation, and the field of pharmaceutical compositions for treating digestive system diseases, can solve problems such as few studies on pharmacological and drug effects, and achieve low immune function. good, good therapeutic effect, good curative effect

Inactive Publication Date: 2014-10-15
CHENGDU UNIV OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Modern science has conducted in-depth research on the chemical components of Atractylodes Rhizome and Magnolia officinalis and the pharmacological effects of each component, but there are very few studies on the pharmacological and pharmacological effects of the chemical components or effective parts that are compatible with each other.

Method used

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  • A pharmaceutical composition for treating digestive system diseases, its preparation method and application
  • A pharmaceutical composition for treating digestive system diseases, its preparation method and application
  • A pharmaceutical composition for treating digestive system diseases, its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Preparation of atractylodes ketone: weigh and crush the decoction pieces of atractylodes atractylodes, add to CO 2 Extract in a supercritical extractor to obtain the extract, and then inject it into a molecular still for two-stage molecular distillation, wherein the evaporation surface temperature of the first stage distillation is 60-90°C, the pressure is 100-150Pa, and the distillation time is 40-80min , collect the distillate for second-stage distillation, the evaporation surface temperature is 30-50°C, the pressure is 60-80Pa, distill for 40-80min, collect the distillate, add acetone, refrigerate and crystallize, separate crystallization, wash and dry have to. In addition to preparing atractylone by this method, it can also be prepared by other conventional methods.

Embodiment 2

[0021] Preparation of magnolol: Weigh magnolia bark decoction pieces and crush them, add sodium hydroxide solution to extract twice, filter to obtain alkaline extract; add hydrochloric acid to the alkaline extract, adjust the pH of the solution to 2-3, and stir for 2-3 hours , stand still for 14 hours, filter with plate sieve, preserve the filtrate, wash the precipitate with water to neutrality, and enter the next step; the precipitate is dissolved in ethanol with a concentration of 70% by weight, extracted by heating, and filtered to obtain filtrate I; Add impurity remover to I, let it stand for 12 hours, and filter to obtain filtrate II; pass the filtrate II over the mixed resin, stand for 2 hours, and wash the separated solution with water until it is a colorless solution; the elution step is to use sodium hydroxide solution first Wash until the color becomes lighter, then elute with sodium hydroxide solution 3 times the volume of the mixed resin and sodium hydroxide solutio...

Embodiment 3

[0023] Weigh 10 g of raw materials atractylodes ketone, 50 g of magnolol, add 100 g of auxiliary materials starch to granulate, 5 g of magnesium stearate, 100 g of dextrin, and 100 g of microcrystalline cellulose, uniformly prepare granules, and compress into tablets to obtain tablets.

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Abstract

The invention discloses a medicine composition for treating a digestive system disease, and a preparation method and use of the medicine composition. The medicine composition is prepared from the following ingredients in parts by weight: 5-20 parts of attractylone, and 5-20 parts of magnolol. The medicine composition disclosed by the invention is prepared from the effective parts of natural medicine raw materials in combination; the medicine composition does not need to be decocted for taking, is good in curative effect, free from toxic and side effects, not easy to produce tolerance, can be prepared into a tablet, a capsule, a pill, a granule, an oral liquid and the like, and has the advantages of portability, easy taking and the like; all the medicines are nontoxic and harmless before and after the extraction; when the medicine composition is taken at normal dosage, no toxic effect and no side effect are found; and the medicine composition is widely applicable to the patients suffering from digestive system diseases.

Description

technical field [0001] The invention belongs to the field of medicines, and relates to a pharmaceutical composition for treating digestive system diseases, in particular to a pharmaceutical composition and a preparation method for treating digestive system diseases made from extracts of traditional Chinese medicine decoction pieces as raw materials. Background technique [0002] With the accelerated pace of life, irregular diet or increased work pressure, more and more people suffer from digestive system diseases, such as various gastritis, enteritis, duodenal ulcer, etc. The gastrointestinal tract is a part of the digestive system. The main components are the main organs for digesting food and absorbing nutrients. Once abnormalities occur, people's health will be seriously affected. Gastrointestinal diseases generally have the characteristics of long course of disease, slow treatment effect, high cost, and easy recurrence after recovery. For the treatment of such diseases, ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/343A61P1/00A61P1/14A61K31/05
Inventor 黄秀深张丰华
Owner CHENGDU UNIV OF TRADITIONAL CHINESE MEDICINE
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