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Drug composition for treating cancers, preparation method and applications

A technology of composition and pharmaceutical preparation, which is applied in the field of pharmaceutical composition and preparation for the treatment of cancer, can solve the problems of less research on the compatibility of compound prescriptions, no compatibility of astragaloside IV and poria cocos polysaccharide, etc., and achieve good and good immune function. Therapeutic effect, intolerable effect

Inactive Publication Date: 2014-03-26
CHENGDU UNIV OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Modern science has conducted in-depth research on the chemical components of Astragalus and Poria cocos and the pharmacological effects of each component, but there are few studies on the compatibility of compound prescriptions, and there is no report on the compatibility of astragaloside IV and Poria cocos polysaccharide

Method used

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  • Drug composition for treating cancers, preparation method and applications

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Preparation of Astragaloside IV: Weigh 1 kg of Astragalus decoction pieces and pulverize them, heat and reflux extraction with water for 3 times, add 10 times the amount of water for reflux extraction for 1.5 hours for the first time, add 8 times the amount of water for reflux extraction for 1 hour for the second and third times, Combine the extracts, add Ca(OH) 2 Appropriate amount of solid powder to make Ca(OH) 2 Saturated solution, placed at room temperature for 16 hours, centrifuged, the supernatant was adjusted to pH 8 with dilute hydrochloric acid solution, added to the HPD-100 macroporous adsorption resin, sugars and salts were washed away with 10 liters of deionized distilled water, and then washed with Wash away impurities with 5 liters of 50% ethanol, then elute astragaloside IV with 5 liters of 80% alcohol, concentrate the eluate, centrifuge, and recrystallize with dilute ethanol to obtain astragaloside IV. In addition to preparing astragaloside IV by this m...

Embodiment 2

[0025] Preparation of Poria cocos polysaccharides: Weigh 1 kg of poria cocos decoction pieces and pulverize them, extract the polysaccharides with water, first use petroleum ether (60 ° C ~ 90 ° C) for 1 hour to remove lipids, add 7500 ml of 90% ethanol, reflux at 85 ° C, and extract 2 times, 2 hours each time. Then use a rotary evaporator to evaporate the solvent, and then extract the polysaccharide with water. The extract is concentrated under reduced pressure at 50°C to 1 / 3 of the original volume. After concentration, add 4 times the amount of 95% ethanol to the aqueous solution, let it stand overnight, and use Suction filter bottle for suction filtration, precipitation, sequentially eluting with absolute ethanol, acetone, ether, the obtained extract is dried in a vacuum oven at 60°C to constant weight, and the obtained powdery extract is pachymansin . In addition to preparing pachyrhin by this method, it can also be prepared by other conventional methods.

Embodiment 3

[0027] Weigh 10 g of raw materials astragaloside IV and 50 g of polysaccharides, add 100 g of auxiliary materials starch to granulate, 5 g of magnesium stearate, 100 g of dextrin, and 100 g of microcrystalline cellulose, uniformly prepare granules, and press into tablets to obtain tablets.

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Abstract

The invention discloses drug composition for treating cancers, a preparation method and applications. The drug composition comprises the components in parts by weight as follows: 1-20 parts of astragaloside and 5-20 parts of pachymaran. The drug composition is formed by combination of effective constituents of natural medicinal materials, can be taken without boiling and has the advantages that the drug composition is good in curative effect, free from toxic and side effects, not prone to tolerance, capable of being prepared into pills, tablets, effervescent tablets, capsules, powder, granules, syrup, oral liquids, freeze-dried injections, injections and the like, convenient to take and carry and the like, each medicinal material is non-toxic and harmless before and after composition extraction, no side effect is found when the normal dose is taken, and the composition is generally applicable to cancer patients.

Description

technical field [0001] The invention belongs to the field of medicaments, and relates to a pharmaceutical composition for treating cancer, in particular to a pharmaceutical composition for treating cancer which is made from extracts of Chinese herbal decoction pieces and a preparation method thereof. Background technique [0002] A tumor is an abnormal lesion formed by a certain cell in a local tissue losing its normal regulation of its growth at the gene level under the action of various carcinogenic factors, resulting in its clonal abnormal proliferation. Malignant tumors are also called cancers. The treatment of tumors in modern medicine is often based on surgery, chemotherapy or radiotherapy. Surgery can remove tumor tissue, and chemotherapy and radiation can shrink or disappear tumors by killing tumor cells. According to its different pathogenesis, different anti-tumor drugs have been developed. [0003] ZL201110020278.1 discloses a composition for treating cancer. Th...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/715A61P35/00A61K31/7048
Inventor 陶铮段俊国路雪婧张富文李强
Owner CHENGDU UNIV OF TRADITIONAL CHINESE MEDICINE
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