A kind of multi-index component uplc detection method of effective components in safflower

A detection method and technology of active ingredients, applied in the field of drug detection, can solve the problems of high detection cost, difficult application, cumbersome detection operations, etc., and achieve the effects of short detection time, reduced consumption, and improved analysis efficiency

Active Publication Date: 2020-09-08
SHAANXI BUCHANG PHARMA
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Problems solved by technology

[0003] Since safflower is frequently used in many traditional Chinese medicine prescriptions, how to effectively evaluate the internal quality of safflower Chinese medicinal materials is a research hotspot in many pharmaceutical factories. The evaluation of multi-component and multi-index control methods came into being, but this quality control method has its drawbacks, its high testing costs and cumbersome testing operations are difficult to apply in industrialized mass production

Method used

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  • A kind of multi-index component uplc detection method of effective components in safflower
  • A kind of multi-index component uplc detection method of effective components in safflower
  • A kind of multi-index component uplc detection method of effective components in safflower

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Embodiment 1

[0031] 1.1 Experimental Instruments

[0032] Waters Acquity H-Class ultra-high performance liquid chromatography; electronic analytical balance; ultrasonic cleaner; Millipore ultrapure water.

[0033] 1.2 Reagents and medicines

[0034] The safflower medicinal material is crushed into 30-40 mesh coarse powder for later use, 6-hydroxy kaempferol-3,6,7-tri-O-glucoside reference substance, hydroxy safflower yellow A reference substance, dehydrated safflower yellow B reference substance Taste. Methanol (chromatographically pure), acetonitrile (chromatographically pure), ultrapure water, and other reagents were analytically pure.

[0035] 1.3 Experimental steps and results

[0036] 1.4 The chromatographic conditions are:

[0037] The chromatographic column is: BEH C18 (4.6mm×100mm, 1.7μm) chromatographic column; filled with ethylene bridge hybrid particles

[0038] Agent; mobile phase A: acetonitrile, mobile phase B: 0.5% formic acid, gradient elution according to the followin...

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Abstract

The invention provides a method for multi-index component UPLC detection of the content of effective components in safflower. The detection method is used to detect the content of 6-hydroxylkaempferol-3,6,7-triglucoside, hydroxysafflor yellow A and anhydrosafflor yellow B in a safflower medicinal material. The detection method has the advantages of simplicity in operation, good accuracy and high efficiency, and can be applied to the intrinsic quality control method of the safflower medicinal material.

Description

technical field [0001] The technology of the invention relates to the field of drug detection, in particular to a method for detecting the content of active ingredients in safflower by multi-index component UPLC. Background technique [0002] Safflower, also known as red and blue flower, thorn safflower, is a dry tubular flower of the safflower plant of the family Asteraceae. Safflower is a traditional medicinal material in my country, which was first recorded in "Kaibao Materia Medica". "Compendium of Materia Medica" claims that safflower can "promote blood circulation, moisten dryness, relieve pain, relieve swelling and relieve menstrual flow. Traditional Chinese medicine believes that safflower is pungent, slightly bitter, warm in nature, returning to the heart and liver meridian. The effect of blood pressure and blood lipid lowering is used for amenorrhea, dysmenorrhea, bruises, coronary heart disease, angina pectoris and hypertension. Safflower has become an important ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N30/02
CPCG01N30/02
Inventor 刘峰黄壮壮马久太孙宇宏苏英英马存德陈衍斌张建卢新义许刚吴云生孙宝平
Owner SHAANXI BUCHANG PHARMA
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