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A near-infrared second-region imaging contrast agent and its preparation method and use

A near-infrared, ethylene glycol technology, applied in the field of nano-biomedical imaging, can solve the problems of poor water solubility, leakage and separation of contrast agents

Active Publication Date: 2020-10-20
NANJING UNIV OF POSTS & TELECOMM
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Conjugated polymers have been used in near-infrared second-region imaging due to their high molar extinction coefficient, wide emission wavelength, and ease of preparation. However, currently available conjugated polymer contrast agents for near-infrared second-region imaging are relatively water-soluble. Poor, prone to leakage and separation when used in vivo, which greatly limits the application of near-infrared second-region imaging in biological applications

Method used

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  • A near-infrared second-region imaging contrast agent and its preparation method and use
  • A near-infrared second-region imaging contrast agent and its preparation method and use
  • A near-infrared second-region imaging contrast agent and its preparation method and use

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Experimental program
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Effect test

Embodiment 1

[0038] Dissolve 10 mg of a triblock polymer with 10 diketopyrrolopyrrole-thiophene block repeating units and 10 poly(ethylene glycol) acrylate block repeating units in 5 ml of water for self-assembly to obtain a contrast agent .

[0039] Such as figure 1 As shown, a concentration of 0.5 mg / mL aqueous solution was prepared, and the microscopic state of the contrast agent was observed with a transmission electron microscope.

[0040] Such as figure 2 Shown, the preparation concentration is 0.5mg / mL aqueous solution, test its hydrodynamic radius.

[0041] Such as image 3 As shown, a concentration of 2 mg / mL aqueous solution was prepared, and Hep G2 tumor mice were selected, and 200 μL was injected into the tail vein, and the signal intensity change map of the tumor position was observed with a near-infrared second-zone imager.

[0042] Such as Figure 4 As shown, the concentration is 0.5mg / mL aqueous solution, and the power is 500mW / cm 2 The 808nm laser was used to irradi...

Embodiment 2

[0047] The contrast agent can be obtained by dissolving 10 mg of a triblock polymer with 10 repeating units of diketopyrrolopyrrole-thiophene block and 30 repeating units of poly(ethylene glycol) acrylate block in 5 ml of water .

Embodiment 3

[0049] Dissolve 15 mg of a triblock polymer with 15 diketopyrrolopyrrole-thiophene block repeating units and 20 poly(ethylene glycol) acrylate block repeating units in 5 ml of water and self-assemble to obtain a contrast agent .

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Abstract

The invention belongs to the technical field of nano biomedical imaging, and relates to a near infrared two-zone imaging contrast agent, and a preparation method and an application thereof. The contrast agent is self-assembled by a three-block polymer, and three blocks comprise an intermediate diketopyrrolopyrrole-thiophene polymer chain segment and poly(ethylene glycol)acrylate polymer chain segments on both sides. The polymer has near-infrared two-zone imaging effect and can be used as the contrast agent to realize near-infrared two-zone imaging and photothermal therapy of tumor. Compared with a conventional near-infrared two-zone imaging contrast agent, the prepared near-infrared two-zone imaging contrast agent has higher water solubility, fluorescence quantum efficiency and imaging penetration depth, and becomes a promising photothermal agent for cancer treatment due to high-efficiency photothermal conversion efficiency.

Description

technical field [0001] The invention belongs to the technical field of nano-biomedical imaging, and specifically relates to a near-infrared two-zone imaging contrast agent and its preparation method and application, aiming at improving the water solubility and fluorescence quantum efficiency of the near-infrared two-zone imaging contrast agent, and having photothermal The effect of treating tumors. Background technique [0002] Fluorescence imaging in the near-infrared window (650-1700nm) has been widely used in biotechnology fields, such as the assessment of liver function, monitoring treatment response in inflammatory arthritis, non-specific tumor targeting and image-mediated tumor therapy, etc. According to the wavelength of light, the near-infrared window can be divided into the first near-infrared region (650-1000nm) and the second near-infrared region (1000-1700nm). [0003] Compared with near-infrared first-region imaging, near-infrared second-region imaging reduces ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08F293/00A61K41/00A61K49/00A61P35/00
CPCA61K41/0052A61K49/0021A61K49/0054A61P35/00C08F293/00
Inventor 孙鹏飞黄婷范曲立袁鹏程
Owner NANJING UNIV OF POSTS & TELECOMM
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