A near-infrared second-region imaging contrast agent and its preparation method and use

A near-infrared, ethylene glycol technology, applied in the field of nano-biomedical imaging, can solve the problems of poor water solubility, leakage and separation of contrast agents
CN108610461BActive Publication Date: 2020-10-20NANJING UNIV OF POSTS & TELECOMM
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
NANJING UNIV OF POSTS & TELECOMM
Publication Date
2020-10-20

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Abstract

The invention belongs to the technical field of nano biomedical imaging, and relates to a near infrared two-zone imaging contrast agent, and a preparation method and an application thereof. The contrast agent is self-assembled by a three-block polymer, and three blocks comprise an intermediate diketopyrrolopyrrole-thiophene polymer chain segment and poly(ethylene glycol)acrylate polymer chain segments on both sides. The polymer has near-infrared two-zone imaging effect and can be used as the contrast agent to realize near-infrared two-zone imaging and photothermal therapy of tumor. Compared with a conventional near-infrared two-zone imaging contrast agent, the prepared near-infrared two-zone imaging contrast agent has higher water solubility, fluorescence quantum efficiency and imaging penetration depth, and becomes a promising photothermal agent for cancer treatment due to high-efficiency photothermal conversion efficiency.
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Description

technical field

[0001] The invention belongs to the technical field of nano-biomedical imaging, and specifically relates to a near-infrared two-zone imaging contrast agent and its preparation method and application, aiming at improving the water solubility and fluorescence quantum efficiency of the near-infrared two-zone imaging contrast agent, and having photothermal The effect of treating tumors. Background technique

[0002] Fluorescence imaging in the near-infrared window (650-1700nm) has been widely used in biotechnology fields, such as the assessment of liver function, monitoring treatment response in inflammatory arthritis, non-specific tumor targeting and image-mediated tumor therapy, etc. According to the wavelength of light, the near-infrared window can be divided into the first near-infrared region (650-1000nm) and the second near-infrared region (1000-1700nm).

[0003] Compared with near-infrared first-region imaging, near-infrared second-region imaging reduces ...

Claims

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