New medical application of compound inhalation preparation of tiotropium bromide and formoterol

A technology of inhalation preparation and tiotropium bromide is applied in the field of pharmaceutical preparations to achieve the effects of inhibiting growth, improving inhibition rate and enhancing anti-lung cancer effect

Inactive Publication Date: 2018-10-09
杭州勃锐思莫生物医药科技有限责任公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

This patented new way of treatments involves combining different types of medicine together into one pill called an antagonist molecule. When this combination works properly they work differently depending upon how well these medicines help fight against certain diseases such as asthma attacks. They may be given separately from any others without affecting their overall healthy state. Overall, this technology provides effective ways to prevent and cure various forms of respiratory illnesses like pulmonary fibrosarcomas and chronic obstructive pulmoneusis.

Problems solved by technology

This patents discuss various aspects related to lung cancer such as its complex nature, poor outcomes due to smokers' lungs compared to other types of carcinoma. There has been increasing research into developing effective treatments against this type of cancer based upon understanding how these conditions lead to progressively increased risk of recurrence and reduced overall patient life expectancy rates.

Method used

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  • New medical application of compound inhalation preparation of tiotropium bromide and formoterol
  • New medical application of compound inhalation preparation of tiotropium bromide and formoterol
  • New medical application of compound inhalation preparation of tiotropium bromide and formoterol

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Embodiment 1 tiotropium bromide and formoterol compound dry powder inhaler (sample 1)

[0021] prescription

[0022] Tiotropium Bromide 22.5mg

[0023] Formoterol 9mg

[0024] Lactose 25g

[0025] craft

[0026] Respectively micronize tiotropium bromide and formoterol for later use, weigh the prescribed amount of the main drug and carrier lactose and pass through a 40-mesh sieve for premixing, and three-dimensionally mix (T2F) the obtained premixes for 5-10 minutes, and then dry powder Filled in 1000 gelatin capsules, 25 mg per capsule (that is, each capsule contains 22.5 μg of tiotropium bromide and 9 μg of formoterol).

Embodiment 2

[0027] Embodiment 2 tiotropium bromide and formoterol compound dry powder inhalation (sample 2)

[0028] prescription

[0029] Tiotropium Bromide 25.2mg

[0030] Formoterol 9mg

[0031] Lactose 25g

[0032] craft

[0033] Respectively micronize tiotropium bromide and formoterol for later use, weigh the prescription amount of the main drug and carrier lactose and pass through 40-mesh sieves respectively. The obtained premix was three-dimensionally mixed (T2F) for 5 minutes, then mixed at a high speed for 10 minutes to obtain a dry powder, and then the dry powder was filled in 1000 gelatin capsules, each 5 mg (that is, each capsule contained 25.2 μg of tiotropium bromide and Moterol 9 μg).

Embodiment 3

[0034] Embodiment 3 tiotropium bromide and formoterol compound dry powder inhalation (sample 3)

[0035] prescription

[0036] Tiotropium Bromide 27mg

[0037] Formoterol 9mg

[0038] Lactose 25g

[0039] craft

[0040] Respectively micronize tiotropium bromide and formoterol for later use, weigh the prescription amount of the main drug and carrier lactose and pass through 40-mesh sieves respectively. Three-dimensionally mix (T2F) the obtained premix for 20 minutes to obtain a dry powder for inhalation, and then fill the dry powder into 1000 gelatin capsules, 13 mg per capsule (that is, each capsule contains 27 μg of tiotropium bromide and 9 μg of formoterol) .

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PUM

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Abstract

The invention provides a new medical application of a compound inhalation preparation of tiotropium bromide and formoterol, namely application to preparation of a medicament for treating lung cancer with chronic obstructive pulmonary disease. The compound inhalation preparation is prepared from tiotropium bromide, formoterol and pharmaceutic adjuvants, wherein the ratio of tiotropium bromide to formoterol is 2.5:1, 2.8:1 or 3:1. Studies show that tiotropium significantly inhibits the growth of lung cancer cells, inhibits the growth of lung cancer transplantable tumors, and produces a strongerbronchodilation effect. Formoterol has no effect on the growth of lung cancer cells and lung cancer transplantable tumors, but can significantly enhance the anti-lung cancer effect and bronchodilationeffect of tiotropium bromide. The compound preparation is administered by airway inhalation, so that the drug concentration of the target organ lung is greatly higher than that of system drug administration, the blood drug concentration and the distribution in other organs are greatly reduced, and the systemic adverse reaction is reduced. The compound inhalation preparation can be applied to treatment of lung cancer with chronic obstructive pulmonary disease.

Description

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Claims

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Application Information

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Owner 杭州勃锐思莫生物医药科技有限责任公司
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