Preparation method of compound anti-scar emulsion biological dressing

Abstract

The invention discloses a preparation method of a compound anti-scar emulsion biological dressing. The preparation method comprises the following steps: 1) preparing a liquid A from hyaluronic acid and water; 2) preparing a liquid B from a growth factor, glycerin and water; and 3) preparing a liquid C from composite active peptide, hydroxyethyl cellulose, glyceryl stearate, xanthan gum, tridecyl alcohol, phenoxyethanol, a witch hazel extract, a scutellaria baicalensis root extract, a raspberry extract, a radix sanguisorbae extract, an onion extract and water; 4) uniformly mixing the liquid A,the liquid B and the liquid C, and filling to obtain the compound anti-scar emulsion biological dressing. According to the compound anti-scar emulsion biological dressing prepared by the method, by compounding gradient hyaluronic acid and active components such as small active peptides, growth factors and plant extracts, skin repairing, protection and skin care of the active components of the active components can be fully performed, efficacy stability of the product is guaranteed, and wound healing and scar prevention and reduction can be promoted.

Description

technical field

[0001] The invention relates to a preparation method of a compound anti-scar emulsion biological dressing. Background technique

[0002] Human skin is an organ directly exposed to the external environment. It is often damaged and eroded by various external factors, resulting in trauma or defect of skin tissue, which requires ideal products for repair and care. The current dressing products mainly focus on protecting the wound environment, promoting wound healing, and preventing wound infection. Although they have played a good role in wound treatment, they do not involve the prevention and reduction of scar formation. The formation not only affects the appearance, but also causes symptoms such as poor perspiration and severe itching, causing great pain to the patient.

[0003] With the development of molecular biology, the research on the application of biomaterials in medical dressings is increasing, and a lot of results have been obtained, such as collagen...

Examples

preparation example Construction

[0026] A preparation method of compound anti-scar emulsion biological dressing, comprising the following steps:

[0027] 1) Based on the relative molecular weight Mr of hyaluronic acid, high molecular weight hyaluronic acid with Mr ≥ 2 million, medium molecular weight hyaluronic acid with 200,000 ≤ Mr < 2 million, and low molecular weight hyaluronic acid with 10,000 ≤ Mr < 200,000 Acid, oligomeric hyaluronic acid with Mr<10,000 and water were mixed and stirred evenly to obtain liquid A;

[0028] 2) mixing epidermal growth factor, keratinocyte growth factor, fibroblast growth factor, glycerin and water, and stirring evenly to obtain liquid B;

[0029] 3) Compound active peptide, hydroxyethyl cellulose, glyceryl stearic acid, xanthan gum, tridecyl alcohol, phenoxyethanol, witch hazel extract, scutellaria root extract, raspberry extract, Burnet extract material, onion extract and water, and stir evenly to obtain liquid C;

[0030] 4) Mix liquid A, liquid B and liquid C evenly, ...

Embodiment 1

[0039] The preparation method of embodiment 1 compound anti-scar emulsion biological dressing, comprises the following steps:

[0040] 1) Weigh 25 grams of high-molecular-weight hyaluronic acid, 5 grams of medium-molecular-weight hyaluronic acid, 15 grams of low-molecular-weight hyaluronic acid, and 5 grams of oligomeric hyaluronic acid, add 1000 mL of ultrapure water, heat and stir to dissolve, and obtain liquid A;

[0041] 2) Weigh 0.5gEGF, 0.25gKGF, 0.25gFGF, 300g glycerin and 1000mL ultrapure water, mix and stir evenly to obtain liquid B;

[0042] 3) Weigh 5g copper tripeptide-1, 20g palmitoyl tetrapeptide-7, 10g acetyl tetrapeptide-9, 5g pentapeptide-3, 5g hexapeptide-10, 5g nonapeptide-1, 20g hydroxyethyl cellulose 150g glyceryl stearic acid, 30g xanthan gum, 200g tridecyl alcohol, 20g phenoxyethanol, 5g witch hazel extract, 20g scutellaria root extract, 10g raspberry extract, 5g Burnet extract, 10g Mix the onion extract with 8000mL ultrapure water, and stir evenly to o...

Embodiment 2

[0045] The preparation method of the compound anti-scar emulsion biological dressing of embodiment 2 comprises the following steps:

[0046] 1) Weigh 20 grams of high molecular weight hyaluronic acid, 10 grams of medium molecular weight hyaluronic acid, 10 grams of low molecular weight hyaluronic acid, and 10 grams of oligomeric hyaluronic acid, add 1000 mL of ultrapure water, heat and stir to dissolve, and obtain A liquid;

[0047] 2) Weigh 0.5gEGF, 0.25gKGF, 0.25gFGF, 200g glycerin and 1000mL ultrapure water, mix and stir evenly to obtain liquid B;

[0048] 3) Weigh 5g palmitoyl tripeptide-5, 5g palmitoyl tetrapeptide-7, 15g acetyl tetrapeptide-9, 5g tetrapeptide-30, 5g pentapeptide-3, 5g hexapeptide-9, 5g hexapeptide- 10. 5g decapeptide-12, 20g hydroxyethyl cellulose, 150g glyceryl stearic acid, 30g xanthan gum, 180g tridecyl alcohol, 20g phenoxyethanol, 5g witch hazel extract, 20g baicalin root extract, 10g raspberry extract, 5g Burnet extract, 10g onion extract and 8000m...

technical field

[0001] The invention relates to a preparation method of a compound anti-scar emulsion biological dressing. Background technique

[0002] Human skin is an organ directly exposed to the external environment. It is often damaged and eroded by various external factors, resulting in trauma or defect of skin tissue, which requires ideal products for repair and care. The current dressing products mainly focus on protecting the wound environment, promoting wound healing, and preventing wound infection. Although they have played a good role in wound treatment, they do not involve the prevention and reduction of scar formation. The formation not only affects the appearance, but also causes symptoms such as poor perspiration and severe itching, causing great pain to the patient.

[0003] With the development of molecular biology, the research on the application of biomaterials in medical dressings is increasing, and a lot of results have been obtained, such as collagen...

Examples

preparation example Construction

[0026] A preparation method of compound anti-scar emulsion biological dressing, comprising the following steps:

[0027] 1) Based on the relative molecular weight Mr of hyaluronic acid, high molecular weight hyaluronic acid with Mr ≥ 2 million, medium molecular weight hyaluronic acid with 200,000 ≤ Mr < 2 million, and low molecular weight hyaluronic acid with 10,000 ≤ Mr < 200,000 Acid, oligomeric hyaluronic acid with Mr<10,000 and water were mixed and stirred evenly to obtain liquid A;

[0028] 2) mixing epidermal growth factor, keratinocyte growth factor, fibroblast growth factor, glycerin and water, and stirring evenly to obtain liquid B;

[0029] 3) Compound active peptide, hydroxyethyl cellulose, glyceryl stearic acid, xanthan gum, tridecyl alcohol, phenoxyethanol, witch hazel extract, scutellaria root extract, raspberry extract, Burnet extract material, onion extract and water, and stir evenly to obtain liquid C;

[0030] 4) Mix liquid A, liquid B and liquid C evenly, ...

Embodiment 1

[0039] The preparation method of embodiment 1 compound anti-scar emulsion biological dressing, comprises the following steps:

[0040] 1) Weigh 25 grams of high-molecular-weight hyaluronic acid, 5 grams of medium-molecular-weight hyaluronic acid, 15 grams of low-molecular-weight hyaluronic acid, and 5 grams of oligomeric hyaluronic acid, add 1000 mL of ultrapure water, heat and stir to dissolve, and obtain liquid A;

[0041] 2) Weigh 0.5gEGF, 0.25gKGF, 0.25gFGF, 300g glycerin and 1000mL ultrapure water, mix and stir evenly to obtain liquid B;

[0042] 3) Weigh 5g copper tripeptide-1, 20g palmitoyl tetrapeptide-7, 10g acetyl tetrapeptide-9, 5g pentapeptide-3, 5g hexapeptide-10, 5g nonapeptide-1, 20g hydroxyethyl cellulose 150g glyceryl stearic acid, 30g xanthan gum, 200g tridecyl alcohol, 20g phenoxyethanol, 5g witch hazel extract, 20g scutellaria root extract, 10g raspberry extract, 5g Burnet extract, 10g Mix the onion extract with 8000mL ultrapure water, and stir evenly to o...

Embodiment 2

[0045] The preparation method of the compound anti-scar emulsion biological dressing of embodiment 2 comprises the following steps:

[0046] 1) Weigh 20 grams of high molecular weight hyaluronic acid, 10 grams of medium molecular weight hyaluronic acid, 10 grams of low molecular weight hyaluronic acid, and 10 grams of oligomeric hyaluronic acid, add 1000 mL of ultrapure water, heat and stir to dissolve, and obtain A liquid;

[0047] 2) Weigh 0.5gEGF, 0.25gKGF, 0.25gFGF, 200g glycerin and 1000mL ultrapure water, mix and stir evenly to obtain liquid B;

[0048] 3) Weigh 5g palmitoyl tripeptide-5, 5g palmitoyl tetrapeptide-7, 15g acetyl tetrapeptide-9, 5g tetrapeptide-30, 5g pentapeptide-3, 5g hexapeptide-9, 5g hexapeptide- 10. 5g decapeptide-12, 20g hydroxyethyl cellulose, 150g glyceryl stearic acid, 30g xanthan gum, 180g tridecyl alcohol, 20g phenoxyethanol, 5g witch hazel extract, 20g baicalin root extract, 10g raspberry extract, 5g Burnet extract, 10g onion extract and 8000m...

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