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Multi-objective optimization method for automatic intensity modulation based on voxel weight factor and its application

A multi-objective optimization, weight factor technique

Active Publication Date: 2022-05-03
SOUTHERN MEDICAL UNIVERSITY
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Problems solved by technology

[0006] In 2007, Breedveld et al. published A novel approach tomulti-criteria inverse planning for IMRT in the Phys Med Bio journal, introducing a multi-objective optimization model that automatically adjusts dose constraints. However, the voxel weight factor used by this method The adjusted model was kept confidential and it was not applied to cervical cancer cases

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  • Multi-objective optimization method for automatic intensity modulation based on voxel weight factor and its application
  • Multi-objective optimization method for automatic intensity modulation based on voxel weight factor and its application
  • Multi-objective optimization method for automatic intensity modulation based on voxel weight factor and its application

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Embodiment 1

[0054] A multi-objective optimization method for IMRT based on voxel weight factors, comprising the following steps:

[0055] (1) Establishment of FMO optimization model based on voxel weight factor

[0056] (1.1) Establishment of optimization objective function

[0057] After the target area and organs at risk of cervical cancer patients are accurately determined, the software package CERR (Computational Environment for Radiotherapy Research) developed and published by the University of Washington in the United States is used as the reverse plan design platform for intensity-modulated radiotherapy. Field parameters, dose calculation engine and parameter information of ROI. For patients with cervical cancer, 7 fields (150 0 ,100 0 ,50 0 ,0 0 ,310 0 ,260 0 ,210 0 ) intensity-modulated irradiation, the ray energy is 6MV, and the prescription dose is 4500cGy. The areas of interest involved include target area, rectum, bladder, intestine, femoral head, bone, body-(target a...

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Abstract

Due to the multi-objective nature of plan optimization and the unknown dose constraints, manual trial-and-error methods are used to repeatedly adjust the dose-constrained optimization plan in clinical practice, which has the problems of low planning efficiency and uncertain quality. The invention discloses a multi-objective optimization method for intensity-modulated radiotherapy based on voxel weight factors, which simulates the thinking mode of plan designers in design and automatically adjusts constraints, thereby ensuring plan quality. This method sorts and classifies the dose constraints of the region of interest according to the clinical importance, forms a constraint priority list, and then adjusts the dose constraints based on the list. When the obtained solution does not satisfy the current constraints, relax the violation items in order of priority; when the obtained solution meets the current constraints, tighten the items in order of priority (tighten the violated dose constraint first), until the final plan is obtained. The above method is applied to patients with cervical cancer, and the results show that the present invention can reduce the workload of plan designers and improve plan quality.

Description

technical field [0001] The invention relates to the technical field of medical radiotherapy, in particular to a multi-objective optimization method for an intensity-modulated radiotherapy plan and the specific application of the method. Background technique [0002] Intensity Modulated Radiation Therapy (IMRT) is currently the most widely used treatment modality. Compared with the traditional three-dimensional conformal radiotherapy technology, intensity-modulated radiotherapy has many potential advantages. Or the dose at the border of organs at risk drops rapidly. Therefore, without reducing the dose of the target area, it can effectively reduce the dose received by normal tissues or organs at risk, improve the tumor control rate (Tumor Control Probability, TCP) or (and) reduce the incidence of normal tissue complications (Normal Tissue Complication Probability , NTCP). [0003] The reverse plan design of intensity-modulated radiotherapy is optimization, the purpose of w...

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G16H20/40G06F30/20
CPCG16H20/40G06F2111/06G06F30/20
Inventor 宋婷麦燕华孔繁图贾启源周凌宏
Owner SOUTHERN MEDICAL UNIVERSITY
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