Gold@gadolinium-based coordination polymer nano compound material and preparation method and application thereof

A nanocomposite material, coordination polymer technology, applied in rare earth metal compounds, nanotechnology, nanotechnology and other directions, can solve problems such as low relaxation rate, achieve simple synthesis method, good biocompatibility, enhanced T1- Effects of MRI Imaging Signals

Active Publication Date: 2018-11-06
JIANGXI NORMAL UNIV
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Problems solved by technology

In rare earth UCNPs, rare earth gadolinium ions (Gd 3+ ) has a large magnetic moment due to seven unpaired electrons, and is currently the most widely used magnetic contrast agent in clinical practice, but the low relaxation rate of Gd and certain nephrotoxicity affect its application, so the development of low toxicity Magnetic contrast agents with strong relaxation properties are very meaningful

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  • Gold@gadolinium-based coordination polymer nano compound material and preparation method and application thereof
  • Gold@gadolinium-based coordination polymer nano compound material and preparation method and application thereof
  • Gold@gadolinium-based coordination polymer nano compound material and preparation method and application thereof

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Embodiment Construction

[0023] Firstly, 0.1mmol allantoin was dissolved in 20mL water and heated until dissolved, then cooled to room temperature; secondly, boiled sodium citrate solution (1mL, 0.035mol / L) and gold nanoparticle solution (2mL) were respectively injected, mixed evenly and placed in Stir magnetically at room temperature for 5 minutes; finally, take a certain concentration of Gd(NO 3 ) 3 , Yb(NO 3 ) 3 , Er(NO 3 ) 3 Aqueous solution (5 mL, 0.02 mol / L) was mixed with the above solution, magnetically stirred at room temperature for 5 minutes, and placed in a 50 mL polytetrafluoroethylene-lined reactor at 160° C. for 15 hours. After the reaction was complete, it was cooled to room temperature, centrifuged, and the product was washed three times with deionized water and ethanol. After drying in a vacuum oven at 60°C for 12 hours, a purple product was obtained, and the sample was designated as Au@GdCP.

[0024] figure 1 are the SEM and TEM images of GdCP and Au@GdCP. from figure 1 It ...

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Abstract

The invention relates to a gold@gadolinium-based coordination polymer core-shell structure multifunctional nano compound material (Au@GdCP) prepared by compounding GdCP:Yb<3+> with up-conversion luminescence performance, Er<3+>(GdCP) nanoparticles and gold nanoparticles (AuNPs) by means of a one-pot method and application of the gold@gadolinium-based coordination polymer core-shell structure multifunctional nano compound material (Au@GdCP) in T1 weighted magnetic resonance imaging (T1-MRI). According to the gold@gadolinium-based coordination polymer core-shell structure multifunctional nano compound material (Au@GdCP) and the application thereof, due to a strong plasma resonance effect (LRET), the gold nanoparticles can improve the magnetic field strength on the periphery of the GdCP and thus play a part in improving the contrast relaxation rate and MRI effect; an adopted hydrothermal synthesis method has the advantages of simple synthesis route, easy adjustment and control, greenness,efficiency and the like; the Au@GdCP can be applied to magnetic contrast imaging due to good biocompatibility, and thus a new pathway is provided for obtaining an efficient magnetic resonance imagingmaterial.

Description

technical field [0001] The invention relates to the field of rare earth up-conversion nanomaterials, in particular to a gold@gadolinium-based coordination polymer nanocomposite material and its preparation method and application. Background technique [0002] Magnetic resonance imaging (MRI) is a non-radiation imaging technique that can be used to observe the structure of diseased tissues, including solid tumors, and is an effective mode of clinical diagnosis. It plays the role of contrast imaging by changing the longitudinal and transverse relaxation time of the water environment in the body. It has the advantage that it does not require ionizing radiation and provides high spatial resolution and high contrast 3D images. [0003] Rare-earth up-conversion nanomaterials (Up conversion, UCNPs) are excited by continuous visible light, and through the reverse Stokes process, multi-photon absorption or energy transfer, they can display unique, high-energy, narrow emission spectr...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K49/08A61K49/18B82Y5/00B82Y15/00C01F17/00
CPCA61K49/08A61K49/183B82Y5/00B82Y15/00C01P2004/03C01P2004/04C01P2004/34C01P2004/62C01F17/30
Inventor 钟声亮肖琛王雷陈燕红宁海金徐先进
Owner JIANGXI NORMAL UNIV
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