Polypeptide and gold nano-antibody capable of targeting HIV (human immunodeficiency virus) envelope protein gp120

Abstract

The invention relates to a polypeptide and a gold nano-antibody capable of targeting an HIV (human immunodeficiency virus) envelope protein gp120. The artificial antibody consists of gold nanoparticles and a section of designed polypeptide sequence. The prepared gold nano-antibody can enhance the binding strength of a drug to a target, namely, when the concentration of the virus gp120 in the bodyis very low, the binding strength can be maintained at a high level. At the same time, the gold nano-antibody has the characteristics of small particle size, excellent dispersibility, good stability and the like, can reach the parts which cannot be reached by common drugs, and can bind to viruses more strongly. Therefore, the artificial antibody has broad application prospects in the field of biomedicine.

Description

technical field [0001] The invention belongs to the field of nanomedicine, and specifically relates to a polypeptide and a gold nanobody capable of targeting HIV envelope protein gp120. Background technique [0002] HIV is easy to induce drug-resistant mutations and has serious side effects on the human body. At the same time, there are problems such as rapid drug failure, high cost, and inability to eradicate. With the development of modern technology and medicine, although highly effective antiretroviral therapy (HAART) and the technology of predicting whether a patient is infected with HIV have been improved, the impact of HIV virus on the human body cannot be eradicated. [0003] At present, reverse transcriptase inhibitors, protease inhibitors and integrase inhibitors are the most used, but long-term medication will cause drug resistance and adverse side effects in the human body, which will also reduce the effect of antiviral therapy. Therefore, it is imminent to deve...

AI Technical Summary

Problems solved by technology

[0002] HIV is easy to induce drug-resistant mutations, and has great toxic and side effects on the human body. At the same time, there are problems such as rapid drug failure, high cost, and inability to eradicate

With the development of modern technology and medicine, although highly effective antiretroviral therapy (HAART) and the technology of predicting whether a patient is infected with HIV have been improved, the impact of HIV virus on the human body cannot be eradicated

[0003] At present, reverse transcriptase inhibitors, protease inhibitors and integrase inhibitors are the most used, but long-term medication will cause drug resistance and adverse side effects in the human body, which will also reduce the effect of antiviral therapy

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