Hepatitis B small three yang low replication period reactivation monitoring equipment during pregnancy and childbirth

Abstract

The invention discloses a monitoring device for reactivation of hepatitis B small three yang low replication period during pregnancy and childbirth, and belongs to the technical field of medical equipment. The monitoring equipment provides a set of feasible, safe and standardized HBV infection reactivation monitoring equipment for pregnant and puerperal subjects, and reduces the adverse pregnancy events caused by the failure of the pregnant and puerperal subjects to discover the reactivation state in time. The monitoring equipment includes a prediction index detection device for detecting a series of prediction indicators for reactivation of hepatitis B small three yang low replication period during pregnancy and childbirth; a data analysis device for obtaining and predicting according to the detection data obtained by the prediction index detection device The detection data of the indicator is a nomogram of the variables. The monitoring device is used for monitoring the reactivation state of pregnant and lying-in women in the low replication period of hepatitis B small three yang.

Description

technical field [0001] The invention relates to the technical field of medical equipment, in particular to a monitoring device for reactivation during pregnancy and childbirth during low replication of hepatitis B small three yang. Background technique [0002] The chronic HBV (hepatitis B virus, hepatitis B virus) infection process generally includes: immune tolerance period, immune clearance period and low replication period. Patients with chronic HBV in the low-replication stage are what we commonly call "small three yang patients". Patients in the low replication phase account for 70-80%. It is characterized by HBeAg (hepatitis B E antigen) disappearance, anti-HBe (hepatitis B e antibody) appears, ALT (alanine aminotransferase, alanine aminotransferase) remains normal, and HBV DNA (hepatitis B virus deoxyribonucleic acid, Hepatitis B virus DNA) remains low It can't even be detected at 2000copies / mL (PCR method). Therefore, it is generally considered that patients in t...

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Problems solved by technology

However, for pregnant women with chronic HBV infection, this kind of immune tolerance and immunosuppression is likely to lead to increased maternal reactivation during the low replication phase of chronic HBV infection

The large increase of estrogen and progesterone during pregnancy increases the burden on the mother’s liver, which may also be the triggering factor for the increase of reactivation during pregnancy, but there is no relevant clinical prospective study

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