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Catalpol-containing medicine composition for reducing blood glucose and preparation method and application thereof

A composition and a technology for lowering blood sugar, which are applied in the field of medicine, can solve problems such as the lack of a radical cure for diabetes, and achieve excellent blood sugar lowering effects, excellent blood sugar lowering effects, and improved blood sugar lowering effects

Active Publication Date: 2018-11-23
北京济全生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Up to now, there is no cure for diabetes. In clinical practice, diet control, sulfonylureas, biguanides, α-glucosidase inhibitors, insulin sensitizers, glibenides, and insulin injections are often used to control blood sugar. levels, slow down the progression of diabetes, and prevent the emergence of diabetic complications

Method used

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  • Catalpol-containing medicine composition for reducing blood glucose and preparation method and application thereof
  • Catalpol-containing medicine composition for reducing blood glucose and preparation method and application thereof
  • Catalpol-containing medicine composition for reducing blood glucose and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] Embodiment 1: a kind of tablet that lowers blood sugar

[0041] Catalpol 50g, microcrystalline cellulose 180g, sodium carboxymethylcellulose 40g, crospovidone 40g, magnesium stearate 3g, prepared according to the following method:

[0042] (1) material preparation: take each raw material according to the formula;

[0043] (2) Preparation: add catalpol, microcrystalline cellulose, sodium carboxymethyl cellulose, and crospovidone to make a soft material, use a 14-mesh sieve to granulate, dry at 40-50°C, and pass through a 12-mesh sieve Whole the grain, add magnesium stearate, mix evenly, and compress into tablets to obtain 1000 tablets for lowering blood sugar.

Embodiment 2

[0044] Embodiment 2: a kind of hypoglycemic capsule

[0045] Catalpol 30g, metformin hydrochloride 20g microcrystalline cellulose 180g, sodium carboxymethylcellulose 40g, crospovidone 40g, magnesium stearate 2g, prepared according to the following method:

[0046] (1) material preparation: take each raw material according to the formula;

[0047] (2) Preparation: add catalpol, metformin hydrochloride, microcrystalline cellulose, sodium carboxymethyl cellulose, and crospovidone to make a soft material, use a 14-mesh sieve to granulate, dry at 40-50°C and pass through 12 Mesh sieve for granulation, add magnesium stearate, mix evenly, fill in gelatin capsule shells, and obtain 1000 hypoglycemic capsules.

Embodiment 3

[0048] Embodiment 3: a kind of decoction for hypoglycemic

[0049] Rehmannia 5g, Yam 4g, Cornus 4g, Danpi 3g, Poria 3g, Alisma 3g, Lychee 2.5g, Atractylodes 2.5g, Ghost Arrow Feather 1.5g, Scrophulariaceae 3g, Epimedium 2.5g, Cistanche 2.5g , black aconite 0.5g, cinnamon 0.8g, gallinacea 2g, ephedra 0.5g, prepared according to the following method:

[0050] (1) material preparation: take each raw material according to the formula;

[0051] (2) Pulverization: Cistanche deserticola and gallinacea are pulverized through a 30-mesh sieve to obtain powder, which is set aside;

[0052](3) Extraction: Add 80% of the total amount of 4 times the total amount of raw land, yam, cornus, paeonol, Poria cocos, Alisma, lychee core, herb, ghost arrow feather, Scrophulariaceae, epimedium, black aconite, cinnamon, and ephedra. % ethanol, soaked for 1.5h, then refluxed for 1.5h, filtered to obtain the filtrate for later use, fully used 3 times of 80% ethanol to reflux extracted the filter resid...

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Abstract

The invention relates to a catalpol-containing medicine composition for reducing blood glucose and a preparation method and application thereof. After the catalpol is singly used, or the catalpol is compounded with other active components, such as one or multiple of sulfonylurea, metformin, alpha-glycosidase inhibitors, insulin sensitization agents, glenn urea medicines or traditional Chinese medicine compositions, the excellent effect of reducing blood glucose, triglyceride, cholesterol and glycated hemoglobin in hyperglycemia mice or rats is realized; the catalpol-containing medicine composition can be widely applied to prevent and treat the diabetes, especially type 2 diabetes.

Description

technical field [0001] The invention belongs to the field of medicines, and in particular relates to a blood sugar-lowering pharmaceutical composition containing catalpol and its preparation method and application. Background technique [0002] With the continuous improvement of people's living standards, hyperglycemia has become one of the main metabolic diseases that seriously plague people's health. Blood sugar is the abbreviation of glucose in the blood. The human body maintains a relatively constant blood sugar level by regulating the source of blood sugar and the balance of metabolism. The blood sugar of adult venous plasma is <6.4mmol / L. The acquisition of blood glucose homeostasis depends on the secretion of insulin, the uptake of blood glucose by peripheral tissues and liver, and the production of sugar by the liver. When the metabolic disorder is caused by insufficient insulin synthesis in the pancreas or decreased insulin sensitivity in peripheral tissues, the ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7048A61K31/155A61K45/06A61K36/8945A61P3/10A61K35/57
CPCA61K31/155A61K31/7048A61K35/57A61K36/076A61K36/17A61K36/284A61K36/296A61K36/37A61K36/40A61K36/54A61K36/64A61K36/65A61K36/71A61K36/714A61K36/77A61K36/808A61K36/884A61K36/8945A61K45/06A61K2236/333A61K2236/39A61P3/10A61K2300/00
Inventor 王玮
Owner 北京济全生物科技有限公司
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