Typed gene group for breast cancers and application of typed gene group

A breast cancer and gene group technology, applied in biochemical equipment and methods, DNA/RNA fragments, microbial determination/inspection, etc., can solve problems such as uncertain ratio, inability to be accurately confirmed, and inaccurate PAM50 molecular typing

Active Publication Date: 2018-12-07
福州大彻精准医学科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The molecular typing of PAM50 is not precise enough, for example, whether there is a normal cell type is still controversial, and the ratio between the subtypes is also uncertain
In addition, PAM50 cannot precisely identify which subtypes require specific chemotherapeutic drugs

Method used

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  • Typed gene group for breast cancers and application of typed gene group
  • Typed gene group for breast cancers and application of typed gene group
  • Typed gene group for breast cancers and application of typed gene group

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Embodiment 1, breast cancer genotyping

[0026] This technology divides breast cancer into three subtypes by detecting gene expression: mesenchymal, proliferative, and metabolic.

[0027] According to the gene expression data of 251 breast cancer patients (GSE3494, Angfei HG-U133A detection platform), we used cluster analysis to obtain three subtypes of breast cancer patients: mesenchymal type, proliferative type and metabolic type. Comparing the gene expression of one of the types with the other two, we get the genetic fingerprints of the three types. Taking the mesenchymal type as an example, the expression value of the genes of this fingerprint in the mesenchymal type is significantly higher than that in the other two subtypes (expression fold FC>1.5, p<0.05). Table 1 lists typical genetic fingerprints (60 genes) of three breast cancer subtypes.

[0028] Table 1 The 60 genes of breast cancer typing gene group

[0029]

[0030]

[0031]

[0032]

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Embodiment 2

[0058] Example 2. Therapeutic Effects of Drugs on Three Subtypes of Breast Cancer

[0059] 1. Patients with mesenchymal breast cancer significantly benefited from tamoxifen

[0060] The gene expression data and clinical data of 189 breast cancer patients were downloaded from the GEO database (GSE2990), and 2 patients had no clinical data. Patient data were obtained from John Radcliffe Hospital, Oxford, UK, and Uppsala University Hospital, Uppsala, Sweden. like figure 1 As shown, in the case of 125 breast cancer patients without drug treatment, there was no significant difference in the recurrence-free survival rate of the three subtypes of breast cancer patients, including 54 patients with mesenchymal type and 38 patients with proliferative type. The number of metabolic patients was 33.

[0061] like figure 2 As shown, the number of patients with mesenchymal breast cancer is 17, the number of proliferative patients is 19, and the number of metabolic patients is 26. After ...

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PUM

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Abstract

The invention provides a typed gene group for breast cancers. The breast cancers can be divided into three subtypes including a mesenchyme type, a proliferation type and a metabolism type, and different subtypes of the breast cancers have different gene expression profiles. Patients with different subtypes of the breast cancers have different responses to endocrinotherapy drugs and chemotherapy drugs, so that the survival rates of the patients suffering the breast cancers can be greatly increased by virtue of proper drugs. The typed gene group can be used for preparing a typed detection kit for typing the breast cancers, is applicable to clinic guiding pharmacy and has important application values in the implementation of the accurate treatment of the breast cancers.

Description

technical field [0001] The invention belongs to the field of biotechnology, and in particular relates to a group of breast cancer typing gene groups and applications thereof. Background technique [0002] High-throughput cancer genomics confirms that breast cancer is not a single disease but a disease composed of multiple subtypes. At present, several subtypes of breast cancer (PAM50, Patent No. WO2009158143 A1) are identified through gene expression profiling: luminal A type, luminal B type, HER2 positive type, basal cell type, and normal cell type. This classification of cancer has a more accurate prediction effect on prognosis. For example, luminal type A is relatively weak in invasiveness and metastasis, has a relatively low risk of recurrence and metastasis after surgery, and is more sensitive to endocrine therapy. Luminal B patients have a moderate prognosis and require endocrine therapy combined with chemotherapy. HER2-positive and basal cell types have a poor prog...

Claims

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Application Information

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IPC IPC(8): C12Q1/6886C12N15/11
CPCC12Q1/6886C12Q2600/158C12Q2600/112
Inventor 雷政登
Owner 福州大彻精准医学科技有限公司
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