An active matrix digital microfluidic chip

Abstract

The invention discloses an active matrix digital microfluidic chip, comprising: a control circuit, a plurality of driving units arranged in an array, and an addressing unit corresponding to the positions of each driving unit; wherein, the control circuit, It is used to apply driving voltage to each driving unit sequentially in the driving stage to control the movement of droplets on each driving unit according to a preset path; in the detection stage, after applying a bias voltage to each addressing unit at the same time, detect each addressing unit The charge loss amount of the unit, and the area where the drive unit corresponding to the addressing unit whose charge loss amount is different from other addressing units is determined as the position of the droplet; wherein, the charge loss amount of each addressing unit is related to the external environment received Depends on light intensity. Because the control circuit can not only control the movement of the liquid droplet, but also realize the positioning of the liquid droplet by means of optical addressing, therefore, the accurate positioning of the position of the liquid droplet can be realized while driving the liquid droplet to move.

Description

technical field [0001] The invention relates to the technical fields of biological detection and biological chips, in particular to an active matrix digital microfluidic chip. Background technique [0002] Digital microfluidic technology can precisely control the movement of droplets, realize the fusion and separation of droplets, and complete various biochemical reactions. Compared with general microfluidic technology, digital microfluidic technology can operate liquid accurately to each droplet, complete the target reaction with less reagent volume, and control the reaction rate and reaction progress more precisely. [0003] Existing active-matrix digital microfluidic chips usually include a control circuit and driving units arranged in a matrix, and the driving voltage is applied to the driving units through the control circuit to make the droplets move according to a preset path. However, when the surface of the drive unit is uneven or has impurities due to raw material...

AI Technical Summary

Problems solved by technology

However, since the active matrix digital microfluidic chip is often used to detect biochemical reactions, the electrical signal may be very weak and the change of the droplet composition will cause the change of the electrical signal, so the accuracy of this method is insufficient.

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