Application of Tea Polyphenols in Prevention and Treatment of PRRS

Abstract

The invention discloses an application of tea polyphenols in the prevention and treatment of porcine reproductive and respiratory syndrome. Experimental studies at all levels prove that the tea polyphenols have a significant antiviral effect on porcine reproductive and respiratory syndrome viruses including a highly-pathogenic strain HP-PRRSV for the first time, and lay a foundation for the development of anti-porcine reproductive and respiratory syndrome novel drugs. It is verified that the tea polyphenols are nontoxic to cells at the cellular level, have the characteristics of strong anti-oxidation ability, no toxic or side effects and no odor, can be taken orally, have no irritation to bodies, are safe and nontoxic, have no mutagenesis, carcinogenesis and teratoeenesis effects, do not cause drug residual, are expected to become novel bioactive molecules for preventing and treating the porcine reproductive and respiratory syndrome, provide prerequisite conditions for the developmentof anti-porcine reproductive and respiratory syndrome drugs of the tea polyphenols, have an excellent application prospect in the prevention and treatment of the porcine reproductive and respiratory syndrome, have many advantages and a wide application foundation, and lay a safe foundation for the use in the animal husbandry.

Description

technical field [0001] The invention belongs to the technical field of veterinary medicine. More specifically, it relates to the application of tea polyphenols in the prevention and treatment of PRRS. Background technique [0002] Porcine reproductive and respiratory syndrome (PRRS), also known as blue ear disease, is caused by porcine reproductive and respiratory syndrome virus (Porcine reproductive and respiratory syndrome virus, PRRSV). PRRS mainly causes abortion and stillbirth in pregnant sows , mummified fetuses, weak piglets, and pigs of all ages, especially piglets, have respiratory symptoms. The characteristic lesion is interstitial pneumonia, and the mortality rate is extremely high. It is a highly contagious global important infectious disease. [0003] In 2006, pig hyperthermia broke out in my country, which caused serious economic losses to the pig industry. Later, this strain was defined as Highly pathogenic porcine reproductive and respiratory syndrome virus ...

AI Technical Summary

Problems solved by technology

[0003] In 2006, pig hyperthermia broke out in my country, which caused serious economic losses to the pig industry. Later, this strain was defined as Highly pathogenic porcine reproductive and respiratory syndrome virus (HP-PRRSV). Pathogenic PRRS (Highly pathogenic porcinereproductive and respiratory syndrome, HP-PRRS) is one of the most damaging diseases to the pig industry, due to the virus's immunosuppressive, antibody-dependent enhancement, persistent infection, viremia There are no good vaccines and drugs to prevent and control PRRS due to the characteristics of long maintenance time

Among them, the inactivated vaccine has the following disadvantages: (1) It requires large doses of vaccination or the application of concentrated antigens, and the immunity period is short, often requiring booster vaccination; (2) It cannot cause local immunity, so that the effect of cellular immunity is weak; (3) It produces complete immunity It takes 2 to 3 weeks, which is not conducive to emergency vaccination and the reduction of vaccine costs; (4) There is a possibility of incomplete inactivation and loose virus

However, the attenuated vaccine has the risk of strong virulence, recombination and potential infection

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