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Novel microfluidic array for efficient cell capture

A microfluidic and array technology, applied in the field of microfluidic arrays, can solve the problems of low cell capture rate and limited application, and achieve the advantages of easy production and processing, simple structure, increased capture rate and detection sensitivity Effect

Active Publication Date: 2018-12-28
DALIAN UNIV OF TECH
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, in the current study, the cell capture rate of the microfluidic chip is not high, which limits its clinical application

Method used

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  • Novel microfluidic array for efficient cell capture
  • Novel microfluidic array for efficient cell capture
  • Novel microfluidic array for efficient cell capture

Examples

Experimental program
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Embodiment Construction

[0019] The application method of the present invention will be further described below through specific examples.

[0020] A new type of microfluidic array for efficient cell capture, the microfluidic array is composed of staggered arcuate micropillars, such as figure 1 , 2 shown. The distance between the centers of adjacent arcuate micropillars in each column is 25.2 μm. The straight lines where the centers of two adjacent rows of arcuate micropillars are located are parallel, separated by 98 μm, and distributed in a staggered manner. The distance between the centers of adjacent arcuate micropillars in each row is 196 μm. The straight lines between the centers of two adjacent rows of micropillars are parallel and distributed in a staggered manner with an interval of 4.83 μm. The arcuate microcolumn, as a microfluidic array monomer, is surrounded by an arc surface and a corresponding chord, such as image 3 As shown, the height of the arched micropillar is 40 μm, the leng...

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Abstract

The invention belongs to the technical field of cell capture devices and relates to a novel microfluidic array for efficient cell capture. A monomer of the microfluidic array is arched microcolumns defined by sections of arcs and corresponding chords, and the height is 30-50 microns. The chords of the arched microcolumns are parallel to a fluid in direction and correspond to the arcs adjacent to the microcolumns in a one-to-one way. The central lines of the adjacent two columns of arched microcolumns are parallel and are distributed in a staggered way, and the central straight lines of the adjacent two columns of arched microcolumns are parallel. The microfluidic array is simple in structure and convenient to manufacture and process, can be applied to clinical test of microfluidic chips later, improves the tumor cell capture rate and detection sensibility and is conductive to early cancer detection and finding.

Description

technical field [0001] The invention belongs to the technical field of cell capture devices, and relates to a microfluidic array based on microfluidic technology and suitable for microfluidic chips to efficiently capture cells. Background technique [0002] In the medical field, it is often necessary to separate specific cells from clinical samples such as blood samples and urine samples, such as capturing and identifying circulating tumor cells in blood samples for cancer diagnosis. Microfluidic chips have the characteristics of less sample consumption, easy integration and miniaturization, and have great advantages in cell sorting. However, in the current study, the cell capture rate of the microfluidic chip is not high, which limits its clinical application. Therefore, it is of great significance to design a new structure for microfluidic chips that can efficiently capture cells in samples to promote the clinical application of microfluidic chips. Contents of the inven...

Claims

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Application Information

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IPC IPC(8): C12M1/00
CPCC12M23/16
Inventor 刘波耿春阳
Owner DALIAN UNIV OF TECH
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