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A detection method for 2-methyl-5-nitroimidazole related substances

A technology for nitroimidazole and related substances is applied in the detection field of 2-methyl-5-nitroimidazole related substances, which can solve the problems of low detection efficiency and low detection accuracy, and achieves simple operation, high detection accuracy and low cost. Effect

Inactive Publication Date: 2019-01-01
HUBEI HONGYUAN PHARMA
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Problems solved by technology

[0002] 2-Methyl-5-nitroimidazole is mainly used in organic synthesis in industry. It is an important intermediate for the synthesis of pharmaceutical raw materials metronidazole, secnidazole, and veterinary drug damexol. 2-methylimidazole is mostly used in industry As a raw material, in concentrated sulfuric acid medium, concentrated nitric acid is added dropwise at high temperature to carry out nitration reaction. The existing technology has low detection efficiency for related substances of 2-methyl-5-nitroimidazole, and its detection accuracy is not high. Therefore, , it is particularly important to solve such problems

Method used

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Embodiment Construction

[0015] In order to deepen the understanding of the present invention, the present invention will be described in further detail below with reference to the embodiments. The embodiments are only used to explain the present invention and do not constitute a limitation on the protection scope of the present invention.

[0016] The present embodiment provides a 2-methyl-5-nitroimidazole related substance detection method, comprising the following steps:

[0017] Step 1: Take the test solution, accurately weigh 60.0mg of the sample, transfer it into a 100ml volumetric flask, dissolve it with the mobile phase solution and dilute to the mark;

[0018] Step 2: Take the standard solution, accurately weigh 60.0mg of the standard 4(5)-nitroimidazole, transfer it into a 100ml volumetric flask, dissolve it with mobile phase and dilute to the mark, take 0.5ml of this solution to another 100ml volumetric flask , dilute to the mark with the mobile phase solution, which is equivalent to 0.5% o...

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Abstract

A detection method for 2-methyl-5-nitroimidazole related substances is disclosed. The method includes adding a blank mobile phase solution, a standard substance solution and a solution of a product tobe detected into automatic sample injectors respectively, injecting 10 [mu]L of each of the solutions into a liquid chromatograph, and calculating the single-impurity content and the total impurity content of the product to be detected through a normalization manner to obtain a detection result. The detection precision is higher, and the method is simple to operate, low in cost and wider in application range.

Description

technical field [0001] The invention relates to the technical field of detection, in particular to a detection method for 2-methyl-5-nitroimidazole related substances. Background technique [0002] 2-Methyl-5-nitroimidazole is mainly used in organic synthesis in industry, and it is an important intermediate for the synthesis of pharmaceutical raw materials metronidazole, secnidazole, and veterinary drug dalmesu, and 2-methylimidazole is mostly used in industry. As raw material, in the concentrated sulfuric acid medium, dropwise concentrated nitric acid at high temperature and carry out nitration reaction to obtain, the prior art is relatively low in the detection efficiency of 2-methyl-5-nitroimidazole related substances, and its detection accuracy is not high, therefore , it is very important to solve this kind of problem. SUMMARY OF THE INVENTION [0003] The invention discloses a method for detecting 2-methyl-5-nitroimidazole related substances. A blank mobile phase so...

Claims

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Application Information

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IPC IPC(8): G01N30/88
CPCG01N30/88G01N2030/8872
Inventor 纪志祥廖胜如邓支华晏浩哲杨秀梅徐开垒方耀邓洋黄佐
Owner HUBEI HONGYUAN PHARMA