Prognosis marker for lung cancer and application thereof

A prognostic marker and marker technology, applied in the field of biomedicine, can solve the problems of tumor cell invasion, lack of treatment measures, metastasis, etc., and achieve the effects of improving molecular diagnosis of prognosis, saving medical costs, and high clinical application value

Inactive Publication Date: 2019-01-04
广州表观生物科技有限公司 +1
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, these treatments rarely achieve the goal of curing lung cancer, and the 5-year survival rate is still only 17%.
The main reason for the high mortality rate of lung cancer is that

Method used

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  • Prognosis marker for lung cancer and application thereof
  • Prognosis marker for lung cancer and application thereof
  • Prognosis marker for lung cancer and application thereof

Examples

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Embodiment Construction

[0039] The present invention will be further described below in conjunction with specific examples, but is not limited thereto.

[0040] The Ensembl ID of the long non-coding RNA gene RP11-434D9.1 is ENSG00000249364, and its cDNA sequence is shown in SEQ ID NO: 1:

[0041] CCCAGTGTGAAGTGAAAGCAAAGTTTTAAAATTTTTTCTCCTCTGCAAGAAAATATATTTCAGAAAATCTCTATCTCAAAAATGAAGCAATTAAGAACTGTCTGGCTGTGAGGATCTGGCCTCAACTTGACTTAAAGCAACAACTTCAGTTACATATCAAGATGTGCGTGAGAATGAACCTGCTCTGCTCAGCCAACGTGCTGAGTGACTTGATGTTTGTAATAAATAAATAAATAAACAACAAACAGGTTGTCATGAAATATCCTTTGTAATTATAAACACAGGAAACTTTCTGAGATGCAAGTGGGTGTTAAATGGTTCAGCAAAGCCAAGCCAGAGCAGTTGGTGTGCTTTGAAATGAAGCAACATTGGAAAAATGAAATCTACTGAAAGATCACTACGTGTTTCAAAGAACTGACTAGAACCAGAACTCTTCAGAAAAGAATGTGCTAAAGGTTTGTCCTTGAGAAGTTTCCAAGCCAAGACACTCCTAGGAGCACTTCCCATTGAGGCCGAAAGGCTCATCCACTTACAGCGATTCATGGGAAAAGAGGACAGCACCCTCATCTTTGGTCCAAGAACACAATCCTGAGTGACACAGGATTGCCCTGAAAGTCAACAGCATCCGTCTTACAAAAATCAACAACACTCGCTTTTCAAACTTCCAAAGAATTTACTGGTCTGGTTTGGCCTTTTGGTGCCACATTCCATTCCAGAAC...

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Abstract

The invention discloses a prognosis marker for the lung cancer and application thereof. The long chain non-coding RNA gene RP11-434D9.1 of the marker is quite related to the prognosis period of patients with the lung cancer, through the marker and expression for detecting the marker, lung cancer prognosis is rapidly, accurately and conveniently predicted, the grading and layering of lung cancer risks are realized according to molecular levels, and patients with different grades of risks are separated obviously. Through co-expression analysis, 238 genes related to the long chain non-coding RP1-434D9.1 are found out, through an enrichment analysis on GO and KEGG pathways of the 238 genes, the molecular functions of the long-chain non-coding RP1-434D9.1 are found out, and important biologicalexperiment clues are provided for improving prognosis molecular diagnosis of the patients with the lung cancer and related medicine targets.

Description

technical field [0001] The invention belongs to the field of biomedicine, and in particular relates to a prognostic marker for lung cancer and its application. Background technique [0002] Lung cancer is one of the malignant tumors with the fastest increasing morbidity and mortality and the greatest threat to the health and life of the population. In the past 50 years, many countries have reported that the morbidity and mortality of lung cancer have increased significantly. The incidence and mortality of lung cancer in men rank first among all malignant tumors, and the incidence and mortality of lung cancer occupy the second place in women. The current standard therapies for lung cancer include surgical resection, platinum-based dual chemotherapy, and radiation therapy. However, these treatments rarely achieve the goal of curing lung cancer, and the 5-year survival rate is still only 17%. The main reason for the high mortality rate of lung cancer is that the patients are ...

Claims

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Application Information

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IPC IPC(8): C12Q1/6886C12N15/113
CPCC12Q1/6886C12Q2600/118C12Q2600/158C12Q2600/178
Inventor 陈梦麟杨学敏张洁霞乐小兵刘艳卉骆颖筠黄凯铃史晓舜
Owner 广州表观生物科技有限公司
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