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A batch complete filtration process of api liquid medicine in the pre-crystal transfer process in pharmaceutical production

A technology of pre-process and liquid medicine, applied in the field of pre-process filtration of pharmaceutical production and crystal transformation, can solve the problems of low separation efficiency, short service cycle of filter elements, low separation precision, etc., achieve high filtration precision, prevent mixed cross-contamination, High purification efficiency

Active Publication Date: 2021-03-09
FEATURE-TEC (WUXI) FILTRATION TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This process has changed the shortcomings of the existing process such as low separation precision, low separation efficiency, short service life of filter elements, and frequent replacement.

Method used

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  • A batch complete filtration process of api liquid medicine in the pre-crystal transfer process in pharmaceutical production

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Embodiment Construction

[0025] The present invention will be described in detail below in conjunction with the implementations shown in the drawings, but it should be noted that these implementations are not limitations of the present invention, and those of ordinary skill in the art based on the functions, methods, or structural changes made by these implementations Equivalent transformations or substitutions all fall within the protection scope of the present invention.

[0026] Such as figure 1 As shown, a batch complete filtration system for API medicinal liquid in the pre-transfer process of pharmaceutical production, including a cleaning liquid tank 1, a medicinal liquid tank 2, a first liquid inlet pump 3, a rotary ceramic membrane filter 4, and a cleaning liquid tank connected in sequence. Liquid tank 5, second liquid inlet pump 6, cluster filter 7, slag tank 8 and compressed air tank 9.

[0027] The outlet of the cleaning liquid tank 1 and the outlet of the medicine liquid tank 2 are respec...

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Abstract

The invention provides a batch complete filtration process of API medicinal liquid in the pre-crystallization process in pharmaceutical production, including fine filtration with a rotary ceramic membrane filter, cluster filter filtration, cluster filter filtrate treatment, batch complete filtration, solid Impurity collection and CPI cleaning steps. The rotary ceramic membrane filtration concentration process is used as the precision filtration process, and the cluster membrane filtration technology is used as the solid-liquid separation treatment of the concentrated liquid in the rotary ceramic membrane filter, and the cluster filter filtrate is returned to the rotary ceramic membrane filter for circulation and filtration. Concentrate continuously, and finally use gas backflushing in the cluster filter to recover the impurities in the thick slurry in the form of solids to achieve complete batch processing. The whole process organically combines two kinds of filters, which makes the process simple, efficient and stable, easy to backwash and regenerate, and convenient to operate and maintain.

Description

technical field [0001] The invention relates to the technical field of filtration in the pre-transformation process of pharmaceutical production, in particular to a filtration process and method for API liquid (raw material medicine) with high-efficiency solid-liquid separation, in-situ cleaning, and complete batch treatment. Background technique [0002] API liquid medicine (raw material medicine) refers to the active substance used in the production of preparations, which is the main component processed into preparations, and is generally obtained by chemical synthesis, DNA recombination, fermentation, enzyme reaction or extraction from natural substances. The production of raw materials includes: chemical synthesis, most of the raw materials are synthesized, such as sulfadiazine; extraction, such as heparin extracted from pig intestines, chondroitin extracted from cartilage; fermentation, most antibiotics are derived from fermentation Processes, such as penicillin, strept...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): B01D36/02
CPCB01D36/02B01D2201/085B01D2221/10
Inventor 王志高彭斌崔鹏何向阳黄平张立勇
Owner FEATURE-TEC (WUXI) FILTRATION TECH CO LTD
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