Paracetamol adsorption material in pharmaceutical industry wastewater, preparation and application thereof

A technology of acetaminophen and the pharmaceutical industry, applied in the direction of adsorption of water/sewage treatment, water pollutants, water/sewage treatment, etc., can solve the problems of long penetration time, complicated operation, low permeability, etc., and achieve a wide linear range, High capture efficiency, high targeting effect

Inactive Publication Date: 2019-01-11
河北地质大学
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Aiming at the disadvantages of long penetration time, expensive equipment, complicated operation and low penetration rate in the existing acetaminophen permeation method, the object of the present invention is to provide a kind of acetaminophen adsorption material in pharmaceutical industry wastewater, its preparation and application, which can be used to acetaminophen

Method used

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  • Paracetamol adsorption material in pharmaceutical industry wastewater, preparation and application thereof
  • Paracetamol adsorption material in pharmaceutical industry wastewater, preparation and application thereof
  • Paracetamol adsorption material in pharmaceutical industry wastewater, preparation and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] 11 parts of ionic liquid [EPy]BF with a mass fraction of 32% 4 and 72 parts of NaH with a mass fraction of 18% 2 PO 4 Mix evenly to obtain a two-phase infiltration system, then add 17 parts of L-cys-PAM-Gel with a mass fraction of 42% to obtain a gel-like mixture, burn the above-mentioned gel-like mixture at 150°C for two hours, and then Stored in a vacuum oven at 40° C. for 48 hours to prepare the adsorption material. The specific process of using the adsorption material of the present invention to capture acetaminophen in pharmaceutical industrial wastewater is to mix the pharmaceutical industrial wastewater and the adsorption material at a mass ratio of 3:1, the adsorption temperature is 26°C, and the adsorption time is 15 minutes.

[0034] The adsorption material was taken out and used to capture acetaminophen in pharmaceutical industry wastewater, and the permeability of the target before and after capture was recorded in Table 1.

Embodiment 2

[0036] The preparation method of this embodiment is the same as that of Example 1, the only difference is that the type of ionic liquid in the preparation process is different, and in this embodiment, the ionic liquid is changed to [2-aemim][PF 6 ] (1-aminoethyl-3-methylimidazolium hexafluorophosphate), the rest of the conditions remain unchanged, and the permeability of the target before and after capture is recorded in Table 1.

Embodiment 3

[0038] The preparation method of this example is the same as Example 1, the only difference is that the type of ionic liquid in the preparation process is different, in this example, the ionic liquid is changed to [cmmim][PF 6 ] (1-acetoxy-3-methylimidazolium hexafluorophosphate), and the rest of the conditions were unchanged, and the permeability of the target before and after capture was recorded in Table 1.

[0039] It can be seen from the above examples and Table 1 that the permeability of acetaminophen in the separation of pharmaceutical industry wastewater is respectively 99.2%, 74.3%, and 59.3% by changing the composition of the ionic liquid in the adsorption material, so [EPy ] BF 4 As an ionic liquid, the permeability of acetaminophen in pharmaceutical industry wastewater is the largest, and the penetration effect is the best.

[0040] Depend on figure 1 , 2 and 3, it can be seen that the ionic liquid in the adsorbent material is [EPy]BF 4 When the ionic liquid is...

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Abstract

The invention discloses a paracetamol adsorption material in pharmaceutical industry wastewater, a preparation method and an application thereof The method comprises the following steps: mixing nitrogen ethylpyridine tetrafluoroborate, sodium dihydrogen phosphate and polyacrylamide-L-cysteine grafted chelate gel, and then performing calcination on a mixture; wherein the calcination temperature is120-150 DEG C; and the mass ratio of the nitrogen ethylpyridine tetrafluoroborate to sodium dihydrogen phosphate to the polyacrylamide-L-cysteine grafted chelate gel is 2:6:2. The method for preparingthe adsorption material is quick and convenient, and special ionic liquid, salt and the grafted chelate gel are used in the preparation, and the prepared adsorption material has high targeting property and collection efficiency. The method has the permeability of paracetamol in the pharmaceutical industry wastewater of up to 99.2%. The paracetamol has a wide linear range, low detection limit andrelatively small standard deviation, which can meet the national requirements for the detection of paracetamol in pharmaceutical industry wastewater.

Description

technical field [0001] The invention belongs to the field of environmental protection, and in particular relates to an adsorption material for acetaminophen in pharmaceutical industrial wastewater, its preparation and application. Background technique [0002] Acetaminophen is an antipyretic and analgesic drug of the acetanilide class, also known as paracetamol (paracetamol), which is a metabolite of phenacetin in the body and belongs to the aniline class. By inhibiting the prostaglandin synthase in the hypothalamic thermoregulation center, reducing the synthesis and release of prostaglandin PGE1, resulting in peripheral blood vessel dilation and sweating to achieve antipyretic effect, its antipyretic effect is similar to that of aspirin, and has no obvious anti-inflammatory effect ;By inhibiting the synthesis and release of prostaglandin PGE1, bradykinin and histamine, etc., it can increase the pain threshold and play an analgesic effect. It belongs to peripheral analgesics...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01J20/30B01J20/28C02F1/28C02F101/34C02F101/38C02F103/34
CPCB01J20/28016B01J20/3028C02F1/28C02F1/281C02F2101/345C02F2101/38C02F2103/343
Inventor 卢昶雨荆秀艳高翔李涵张清云苏彤张雯露余悦
Owner 河北地质大学
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