Preparation method of starch-based porous micro-spheres

A technology for microspheres and starch, applied in the field of preparation of starch-based porous microspheres, can solve the problems of low porosity of starch-based microspheres, etc., and achieve the effects of improving binding force, increasing porosity, and improving the degree of cross-linking.

Active Publication Date: 2019-01-11
山东聊城华阳医药辅料有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The technical problem mainly solved by the present invention is: aiming at the disadvantage of low porosity of traditional starch-based microspheres, a preparation method of starch-based porous microspheres is provided

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 1

[0024] Mix the surfactant and the solvent at a mass ratio of 1:15, stir and mix for 50 minutes at a temperature of 55°C and a rotational speed of 400r / min to obtain No. 1 mixed solution, and mix sodium carbonate and water at a mass ratio of 2: 7. Mix, and add polyvinylpyrrolidone with 0.4 times the mass of sodium carbonate to the mixture of sodium carbonate and water, and stir and mix for 80 minutes at a temperature of 65°C and a rotation speed of 400r / min to obtain No. 2 mixed solution. No. mixed solution and No. 2 mixed solution were mixed at a volume ratio of 7:3, and after ultrasonic dispersion at a frequency of 55kHz for 60 minutes, an emulsion was obtained. The emulsion and calcium chloride solution were mixed at a volume ratio of 1:3, and the Under the conditions of 55°C and 400r / min, stir and mix for 80 minutes, filter to obtain microsphere blanks, wash the microsphere blanks with water 10 times, and dry them at 80°C for 2 hours to obtain microspheres ; Mix the microsp...

example 2

[0026] Mix the surfactant and the solvent at a mass ratio of 1:15, stir and mix for 50 minutes at a temperature of 55°C and a rotational speed of 400r / min to obtain No. 1 mixed solution, and mix sodium carbonate and water at a mass ratio of 2: 7. Mix, and add polyvinylpyrrolidone with 0.4 times the mass of sodium carbonate to the mixture of sodium carbonate and water, and stir and mix for 80 minutes at a temperature of 65°C and a rotation speed of 400r / min to obtain No. 2 mixed solution. No. mixed solution and No. 2 mixed solution were mixed at a volume ratio of 7:3, and after ultrasonic dispersion at a frequency of 55kHz for 60 minutes, an emulsion was obtained. The emulsion and calcium chloride solution were mixed at a volume ratio of 1:3, and the Under the conditions of 55°C and 400r / min, stir and mix for 80 minutes, filter to obtain microsphere blanks, wash the microsphere blanks with water 10 times, and dry them at 80°C for 2 hours to obtain microspheres ;Mix the mixed st...

example 3

[0028]Mix the surfactant and the solvent at a mass ratio of 1:15, stir and mix for 50 minutes at a temperature of 55°C and a rotational speed of 400r / min to obtain No. 1 mixed solution, and mix sodium carbonate and water at a mass ratio of 2: 7. Mix, and add polyvinylpyrrolidone with 0.4 times the mass of sodium carbonate to the mixture of sodium carbonate and water, and stir and mix for 80 minutes at a temperature of 65°C and a rotation speed of 400r / min to obtain No. 2 mixed solution. No. mixed solution and No. 2 mixed solution were mixed at a volume ratio of 7:3, and after ultrasonic dispersion at a frequency of 55kHz for 60 minutes, an emulsion was obtained. The emulsion and calcium chloride solution were mixed at a volume ratio of 1:3, and the Under the conditions of 55°C and 400r / min, stir and mix for 80 minutes, filter to obtain microsphere blanks, wash the microsphere blanks with water 10 times, and dry them at 80°C for 2 hours to obtain microspheres ; Mix the microsph...

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Abstract

The invention discloses a preparation method of starch-based porous micro-spheres and belongs to the technical field of natural high molecular materials. The preparation method comprises the followingsteps: mixing a starch-based porous micro-sphere blank with water in a mass ratio of 1: 10 to 1: 15 and adding amylase which is 0.02-0.05 time of the starch-based porous micro-spheres by mass and lipase which is 0.01-0.002 time of the starch-based porous micro-spheres by mass into a mixture of the starch-based porous micro-sphere blank and water; stirring and mixing the mixture; filtering the mixture to obtain pre-treated starch-based porous micro-spheres; mixing the pre-treated porous micro-spheres with 10-18% by mass hydrochloric acid in a mass ratio of 1: 5 to 1: 6; stirring and mixing themixture; filtering the mixture to obtain a filter cake; washing the filter cake with deionized water for 5-8 times; and drying the filter cake at 80 DEG C for 2-3 hours to obtain the starch-based porous micro-spheres. The starch-based porous micro-spheres prepared by the technical scheme have the characteristic of high porosity and have a wide prospect in development of natural high molecular material technology.

Description

technical field [0001] The invention discloses a preparation method of starch-based porous microspheres, belonging to the technical field of natural polymer materials. Background technique [0002] Starch is a naturally renewable, inexpensive and sustainable polysaccharide, which is considered as an alternative material for industrial polymers. In recent years, it has been discovered that starch-based microspheres prepared from starch have many advantages and uses. For example, starch microspheres have the advantages of biocompatibility, biodegradability, non-toxicity, stable storage, wide source of raw materials, and low price. , has been used as a drug carrier for targeted preparations in the fields of nasal drug delivery system, arterial embolization technology, radiotherapy, and immunoassay; starch microspheres can also be used as adsorbents and embedding agents to absorb or embed drugs. In addition to other substances, such as flavors, fragrances, enzymes and spores; c...

Claims

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Application Information

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IPC IPC(8): C08J9/40C08J9/38C08J9/26C08L3/02C08L3/04C08L5/08C08L1/28C08L91/00
CPCC08J9/26C08J9/38C08J9/40C08J2201/0444C08J2303/04C08J2401/28C08J2403/04C08J2405/08C08J2491/00
Inventor 刘茂龙刘侠宋宇星
Owner 山东聊城华阳医药辅料有限公司
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