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Artificial dermis repair material and preparation method thereof

A technology for repairing materials and dermis, applied in skin transplantation, medical science, prosthesis, etc., can solve problems such as wound infection, and achieve the effect of easy suture, high strength and good fit

Active Publication Date: 2019-01-22
SHENZHEN QIKANG MEDICAL DEVICES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the existing artificial dermal substitutes still cannot meet the requirements of ideal dermal substitutes, and there are problems such as vascularization and wound infection in clinical application.

Method used

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  • Artificial dermis repair material and preparation method thereof
  • Artificial dermis repair material and preparation method thereof
  • Artificial dermis repair material and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046] This embodiment provides a kind of artificial dermis restoration material, and its preparation process is as follows:

[0047] S1. Preparation of collagen complex layer:

[0048] The collagen was weighed and dissolved in water to prepare 200 g of a collagen solution with a mass concentration of 0.3%, and 0.056 g of chondroitin sulfate was weighed and dissolved in water to prepare a chondroitin sulfate solution with a mass concentration of 1.7 mg / mL. The above-mentioned chondroitin sulfate solution was atomized into the collagen solution through high-speed airflow, and stirred continuously for 2 hours to obtain a collagen-chondroitin sulfate complex. Centrifuge the collagen-chondroitin sulfate complex at 8000rpm for 15min, collect the precipitate, add 0.05M acetic acid to redissolve the precipitate, make the collagen concentration 0.9% (w / w), and stir for 2.5h to disperse evenly to form collagen-sulfuric acid Dispersion of chondroitin complex, its characterization, AFM ...

Embodiment 2

[0063] This embodiment provides a kind of artificial dermis restoration material, and its preparation process is as follows:

[0064] S1. Preparation of collagen complex layer:

[0065] The collagen was weighed and dissolved in water to prepare 200 g of a collagen solution with a mass concentration of 0.3%, and 0.013 g of chondroitin sulfate was weighed and dissolved in water to prepare a chondroitin sulfate solution with a mass concentration of 0.37 mg / mL. The above-mentioned chondroitin sulfate solution was atomized into the collagen solution through high-speed airflow, and stirred continuously for 2 hours to obtain a collagen-chondroitin sulfate complex. Centrifuge the collagen-chondroitin sulfate complex at 8000rpm for 15min, collect the precipitate, add 0.03M acetic acid to redissolve the precipitate, make the collagen concentration 0.9% (w / w), and stir for 2.5h to make it uniform. Add glutaraldehyde in acetic acid solution to form a collagen composite solution, so that ...

Embodiment 3

[0074] This example provides three kinds of artificial dermis repair materials, which are the same as Example 1, except that the content of PHMB is 1.2%, 6% and 12% respectively. Antibacterial experiments were carried out on the above three artificial dermis repair materials, and the operation was as follows: the artificial dermis repair materials were cut into discs with a diameter of 12 cm, and sterilized by ultraviolet irradiation for 30 minutes in an ultra-clean bench. Prepare MH agar medium, heat to dissolve completely, and sterilize at 121°C for 15 minutes. When the temperature drops to 40-50°C, pour it into a plate in a sterile environment, cool and solidify for later use. Use a sterile cotton swab to take the corrected 0.5 McFarland turbidity (one McFarland turbidity = 3*10 8 cfu / ml) of Escherichia coli and Staphylococcus aureus, gently squeeze out the excess bacteria against the tube wall. Use a cotton swab to coat the entire medium surface, rotate the plate 60 degre...

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Abstract

The invention discloses an artificial dermis repair material and a preparation method of the artificial dermis repair material. The artificial dermis repair material comprises a silicone rubber layerand a collagen compound layer which are adhered together, wherein the collagen compound layer is prepared through the cross-linking reaction on the raw materials comprising collagen, mucopolysaccharide and an antibacterial agent; the silicone rubber layer has high strength, high elasticity and flexibility, is easy in suture, and has good lamination; and the collagen compound layer has good biocompatibility, degradability and antibacterial property, and is suitable for repairing and reconstruction of the dermis tissue.

Description

technical field [0001] The invention relates to the fields of medical equipment and tissue engineering regeneration, in particular to an artificial dermis repair material and a preparation method thereof. Background technique [0002] The skin is the largest organ of the human body. It can protect the body from the invasion of harmful substances from the outside, prevent the loss of water and electrolytes in the body, maintain the stability of the internal environment of the human body, and participate in the immune and metabolic processes of the human body. Skin tissue defects caused by burns, diseases, physical trauma, wars, etc. affect people's quality of life and even threaten their lives. According to the report of the World Health Organization (WHO) (January 2018), 180,000 people die of burns every year in the world. In 2004, nearly 11 million people in the world were severely burned and needed medical treatment; Expenditures exceeded US$ 211 million; in 2007, hospita...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/20A61L27/24A61L27/54A61L27/58A61L27/60A61F2/10
CPCA61L27/20A61L27/24A61L27/54A61L27/58A61L27/60A61F2/105A61F2210/0004A61L2300/254A61L2300/404C08L89/00C08L5/08A61L27/18A61L27/56A61L27/26A61L2300/206C08L83/04C08L89/06A61L27/165
Inventor 王丹妍谭荣伟佘振定郭远军刘曦许孟强陈滢滢
Owner SHENZHEN QIKANG MEDICAL DEVICES
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