A kind of traditional Chinese medicine nano medicine and its preparation method and application

A nano-drug, traditional Chinese medicine technology, applied in the direction of drug combination, pharmaceutical formula, active ingredient of hydroxyl compounds, etc., can solve the problems of low drug-to-lipid ratio, instability, etc., to inhibit cell proliferation and migration, prevent the formation of thrombus, safe and efficient The effect of drug delivery

Active Publication Date: 2021-08-06
SHANGHAI NINTH PEOPLES HOSPITAL SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Traditional liposomes entrap honokiol, most of which are entrapped in the hydrophobic region of the liposome bilayer membrane, with a low drug-to-lipid ratio, and honokiol has a phenol group, which is easy to interact with various ions in the solvent rather unstable

Method used

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  • A kind of traditional Chinese medicine nano medicine and its preparation method and application
  • A kind of traditional Chinese medicine nano medicine and its preparation method and application
  • A kind of traditional Chinese medicine nano medicine and its preparation method and application

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preparation example Construction

[0047] The embodiment of the present invention also discloses a preparation method of a traditional Chinese medicine nano-medicine, which is applied to any of the above-mentioned traditional Chinese medicine nano-medicines, and the method includes the following steps:

[0048] S1. Preparation of mixed materials:

[0049] (1) Select an appropriate amount of silicon dioxide and wait for the next step;

[0050] (2) Select an appropriate amount of small molecule traditional Chinese medicine and wait for the next step;

[0051] (3) Mix the selected silicon dioxide and small molecule traditional Chinese medicine according to an appropriate ratio, etc.

[0052] Wait for the next step;

[0053] (4) Select an appropriate amount of organic solution and wait for the next step.

[0054] S2. Mixing reaction of materials:

[0055] (1) Add the silica / small molecule traditional Chinese medicine mixed material obtained in step 3 of S1 to S1

[0056] In the organic solution obtained in the...

Embodiment 1

[0082] Embodiment 1, the preparation method of mesoporous carrier silica / honokiol

[0083] The mesoporous carrier silica and honokiol were weighed and mixed at a mass ratio of 2:1, placed in a light-proof ep tube, and an appropriate amount of absolute ethanol was added to make the mesoporous carrier silica The concentration in the water ethanol is 2mg / ml, the concentration of honokiol is 1mg / ml, put the ep tube in the mixer and shake overnight, so that the small molecules of honokiol are fully absorbed and accommodated by the mesoporous structure, and the anhydrous After ethanol is blown dry with nitrogen, add the same volume of deionized water to suspend the mesoporous carrier silica / honokiol nanoparticles evenly in deionized water. In order to prevent honokiol from being released from the mesoporous, Cause the disintegration of silicon dioxide, freeze-dry the aqueous solution of mesoporous carrier silicon dioxide / honokiol nanoparticles, and store the freeze-dried powder at...

Embodiment 2

[0085] Example 2. Morphological detection of mesoporous carrier silica / honokiol

[0086] The morphology of the pre-prepared mesoporous carrier silica / honokiol nanoparticles was observed by transmission electron microscopy. The specific method is to use deionized water as the dispersion medium to dilute the above-prepared freeze-dried powder, then take 10 ul of the diluted freeze-dried powder and add it dropwise to a copper grid covered with a carbon film, and after 1 minute, use filter paper to absorb the excess solution, and use Bio-TEM observation of mesoporous carrier silica / honokiol nanoparticles.

[0087] For the morphology of nanoparticles, see figure 2 , the mesoporous structure in mesoporous silica can be seen.

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Abstract

The present invention relates to the field of pharmaceutical technology, specifically a traditional Chinese medicine nano-medicine and its preparation method and application. The specific construction method of the preparation of the traditional Chinese medicine nano-medicine and its preparation method and application: mesoporous carrier silica and small molecule traditional Chinese medicine (such as : honokiol, curcumin, platycodon saponin, etc.) are weighed and mixed in a suitable ratio, dissolved in an appropriate amount of organic solvent (such as: absolute ethanol, chloroform, isopropanol, etc.), placed in a mixer, Shake overnight in the dark, remove the organic solvent, and add deionized water. The advantage of the preparation method is that the mesoporous carrier silicon dioxide is accommodated in the mesoporous structure of the silicon dioxide nanoparticle by absorbing the insoluble small molecule traditional Chinese medicine to form the drug-loaded nanoparticle drug. The mesoporous carrier silica has good biocompatibility, can be adsorbed on the cell surface and quickly taken up by the cells. After entering the cells, the drug in the mesoporous pores is continuously released, disintegrated by itself, and excreted by the urinary system, which is safe and efficient drug delivery.

Description

technical field [0001] The invention relates to the technical field of medicines, in particular to a traditional Chinese medicine nanomedicine and its preparation method and application. Background technique [0002] In recent years, for the treatment of advanced coronary heart disease, most of them require percutaneous coronary intervention. The implantation of the stent improves the coronary stenosis, but also severely damages the integrity of the coronary intima, induces the production and secretion of various cytokines, and the cytokines act on the smooth muscle cells of the vascular media, making the smooth muscle cells change from a quiet state The contractile type dedifferentiates into a proliferative type, and the change of cell phenotype causes a large number of proliferation and migration of smooth muscle cells, forming a new thrombus in the coronary artery [Ma Shaojun. The role of transforming growth factor β1 in the formation of restenosis after vascular injury[J...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/51A61K47/04A61K47/52A61K31/05A61K31/12A61K31/704A61P9/10A61P9/14A61P7/02
CPCA61K9/5115A61K31/05A61K31/12A61K31/704A61K47/52A61P7/02A61P9/10A61P9/14A61K2300/00
Inventor 陆平袁伟恩魏晓盛净蔡文玮成静苑子涵徐阳方志伟
Owner SHANGHAI NINTH PEOPLES HOSPITAL SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
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