A kind of traditional Chinese medicine nano medicine and its preparation method and application
A nano-drug, traditional Chinese medicine technology, applied in the direction of drug combination, pharmaceutical formula, active ingredient of hydroxyl compounds, etc., can solve the problems of low drug-to-lipid ratio, instability, etc., to inhibit cell proliferation and migration, prevent the formation of thrombus, safe and efficient The effect of drug delivery
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[0047] The embodiment of the present invention also discloses a preparation method of a traditional Chinese medicine nano-medicine, which is applied to any of the above-mentioned traditional Chinese medicine nano-medicines, and the method includes the following steps:
[0048] S1. Preparation of mixed materials:
[0049] (1) Select an appropriate amount of silicon dioxide and wait for the next step;
[0050] (2) Select an appropriate amount of small molecule traditional Chinese medicine and wait for the next step;
[0051] (3) Mix the selected silicon dioxide and small molecule traditional Chinese medicine according to an appropriate ratio, etc.
[0052] Wait for the next step;
[0053] (4) Select an appropriate amount of organic solution and wait for the next step.
[0054] S2. Mixing reaction of materials:
[0055] (1) Add the silica / small molecule traditional Chinese medicine mixed material obtained in step 3 of S1 to S1
[0056] In the organic solution obtained in the...
Embodiment 1
[0082] Embodiment 1, the preparation method of mesoporous carrier silica / honokiol
[0083] The mesoporous carrier silica and honokiol were weighed and mixed at a mass ratio of 2:1, placed in a light-proof ep tube, and an appropriate amount of absolute ethanol was added to make the mesoporous carrier silica The concentration in the water ethanol is 2mg / ml, the concentration of honokiol is 1mg / ml, put the ep tube in the mixer and shake overnight, so that the small molecules of honokiol are fully absorbed and accommodated by the mesoporous structure, and the anhydrous After ethanol is blown dry with nitrogen, add the same volume of deionized water to suspend the mesoporous carrier silica / honokiol nanoparticles evenly in deionized water. In order to prevent honokiol from being released from the mesoporous, Cause the disintegration of silicon dioxide, freeze-dry the aqueous solution of mesoporous carrier silicon dioxide / honokiol nanoparticles, and store the freeze-dried powder at...
Embodiment 2
[0085] Example 2. Morphological detection of mesoporous carrier silica / honokiol
[0086] The morphology of the pre-prepared mesoporous carrier silica / honokiol nanoparticles was observed by transmission electron microscopy. The specific method is to use deionized water as the dispersion medium to dilute the above-prepared freeze-dried powder, then take 10 ul of the diluted freeze-dried powder and add it dropwise to a copper grid covered with a carbon film, and after 1 minute, use filter paper to absorb the excess solution, and use Bio-TEM observation of mesoporous carrier silica / honokiol nanoparticles.
[0087] For the morphology of nanoparticles, see figure 2 , the mesoporous structure in mesoporous silica can be seen.
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