52results about How to "Safe and efficient delivery" patented technology

The invention discloses an intelligent cerebral stroke drug carrier for ROS (reactive oxygen species) response and a preparation method of the drug carrier. The carrier is a nano vesicle, hydrophobic boric acid ester is grafted to hydrophilic glucan framework to form amphiphilic block copolymers, the amphiphilic block copolymers serve as carrier materials to prepare the nano vesicle, and the nano vesicle encapsulates neuroprotective agents NR2B9C. The preparation method includes the steps: performing covalent grafting for the boric acid ester and glucan; preparing a nano vesicle carrier by grafting reaction carrier materials in an automatically filling manner; encapsulating the neuroprotective agents NR2B9C in the nano vesicle carrier. The weight ratio of the boric acid ester and the glucan is 10: (5-25), the carrier easily responds degradation of ROS mediation, so that drugs rapidly release at cerebral ischemia lesion positions, and release in non-lesion areas is decreased, so that the neuroprotective agents are more safely and effectively transmitted in intracerebral target areas.

The invention discloses a cooling agent hydrogenation system and method for a small reactor, and relates to the field of cooling agent hydrogenation systems of nuclear power reactors. The system comprises a demineralized water supplying system and a hydrogen storing device, wherein the demineralized water supplying system comprises a demineralized water supplying device, a water pump and a demineralized water loop; the demineralized water supplying device and the water pump are sequentially connected through a pipeline; an inlet of the demineralized water loop is connected to an outlet of thedemineralized water supplying system, and an outlet of the demineralized water loop is connected to an inlet of a cooling agent system; an outlet of the hydrogen storing device is connected to the demineralized water loop. The system is simple in principle, compact in structure, applicable to a small reactor with limited space, and particularly a boron-free small reactor, and is high in operability, high in hydrogenation pressure, safe and efficient to convey.

The invention discloses an upper and lower combined scraping plate transmission mechanism for track type ballast scarifiers, comprising driving chain wheels (3) and driven chain wheels (1) installed on both ends of a transmission shaft. Each pair of driving chain wheels and driven chain wheels is provided with roller chains; an inner chain plate (7) is arranged between the two roller chains; the roller chains are formed by mutually connecting rollers (4); the inner chain plate is provided with a scraping plate I (6) and a scraping plate II (8); rubber plates (2) are arranged among the scraping plate I, the scraping plate II and the inner chain plate; the cross sections of the scraping plate I and the scraping plate II are arc hopper-shaped cross sections; and the scraping plate II (8) is higher than the scraping plate I (6). In the invention, the scraping plates are changed into arc hopper-shaped cross sections and are designed into shapes with different heights. Thereby, pasty materials accumulated on the bottom of the scraping plates can be transmitted to the upper part, achieving the purpose of transmitting the pasty materials. Moreover, stone blocks, especially large stone blocks, can be transmitted efficiently and safely in large-angle oblique mine tunnels. The upper and lower combined scraping plate transmission mechanism has the advantages of compact structure, strong applicability and high transmission efficiency and is widely suitable for transmitting the pasty materials and the large stone blocks in the oblique mine tunnels.

The invention belongs to the field of bioengineering and medicine, and particularly relates to an mRNA-liposome complex for introducing mRNA with modification into cells as well as application, a preparation method and the like of the mRNA-liposome complex. The mRNA-liposome complex contains a transfection reagent and at least one mRNA with modification. Inconspicuously, the mRNA-liposome complexcan efficiently mediate in vivo transfection of mRNA to a plurality of organs in a topical delivery manner. According to the mRNA-liposome complex, intracellular delivery of modified mRNA, resulting in gene expression, can be used to study biological functions of specific genes, can also correct / treat diseases caused by gene deletion or low gene expression. In addition, the mRNA-liposome complex can be used as a nucleic acid vaccine to prevent infectious diseases and treat cancer. In addition, administration of the mRNA-liposome complex is very simple and convenient, and is safe and effective.

This invention provides one IPv6 data collection system based on IEEE 1451.4 intelligent sensor, which comprises n sensor interfaces to meet IEEE 1451.4, wherein, the data collector comprises one imbed network controller connected to Ethernet chip through signal line and connected to sensor interface circuit through signal line and to connect output of chip with isolation transducer input end; the isolation transducer output end is connected to RJ45 interface as interface connected to IPv6 network.

The invention belongs to the technical field of fitness equipment, and discloses a load-bearing inverted abdominal muscle training device capable of stimulating muscles in multiple directions and a using method thereof. The invention discloses the load-bearing inverted abdominal muscle training device capable of stimulating muscles in multiple directions. The device comprises a bottom plate, fourcorners of the upper surface of the bottom plate are fixedly connected with four corners of the lower surface of a top frame through four vertical rods respectively, an auxiliary handle is fixedly connected to the left side of the lower surface of the top frame, a weight adjusting frame is fixedly connected to the right end of the lower surface of the top frame, and a limiting plate is fixedly connected to the middle of the weight adjusting frame. The invention discloses the load-bearing inverted abdominal muscle training device capable of stimulating muscles in multiple directions, a load point position adjusting mechanism is arranged; the stress point of a trainee in the upside-down abdominal curl process can be adjusted, stronger stimulation can be provided for abdominal muscles, the stimulation on the abdominal muscles is more targeted by adjusting the stress point, the comprehensive development and sufficient training of the abdominal muscles are facilitated, and the requirement of weightlifting athletes for abdominal muscle training intensity can be fully met.

The invention discloses a heading machine cutting head assisted by high-pressure water jet. The cutting head comprises a cutting shaft, a cone, a core sleeve, a cutting pick assembly, and a core head; the cone is sleevedly connected to the periphery of the core head and the core sleeve; the cutting shaft is sleevedly arranged in the inner cavity of the core sleeve, and is inserted into a matched inner cavity in the inner of the core head so as to drive the cutting head to move; a pick seat runner, a pick body runner and a nozzle are arranged in the cutting pick assembly; the cutting shaft is provided with a water inlet hole and a main runner, one end of the water inlet hole is connected to a high-pressure water source, the other end of the water inlet hole is connected to the main runner; the core head is provided with a core head runner, and the cone is provided with a cone runner. The high-pressure water is introduced into the cutting head through the water inlet hole, then orderly flows through the core head runner and the cone runner, and finally flows into the cutting grid assembly; in the cutting grid assembly, the high-pressure water orderly flows through the grid seat runner and the grid body runner, and finally flows into the nozzle so as to form a high-pressure water jet which assists the cutting head to break rocks. The cutting head has a shape as the common cutting heads, so the cutting head can be applied to the cutting mechanism of heading machines in the same type, and thus has a wide application range.

The invention relates to the technical field of hotpot condiment processing, and discloses an automatic filling and packaging machine for hotpot condiments. The automatic filling and packaging machinecomprises a filling and packaging machine body, wherein a support is fixedly connected to the bottom of the filling and packaging machine body; a discharge frame is fixedly connected to the left sideof the filling and packaging machine body; a positioning sleeve is fixedly connected to the outer wall of the left side of the filling and packaging machine body; a positioning rod is inserted into the positioning sleeve; a conveying box is fixedly connected to the left end of the positioning rod; a spring is movably connected to the inside of the positioning rod; a clamping rod is fixedly connected to the top of the spring; four universal wheels are rotationally connected to the bottom of the conveying box; and a push frame is fixedly connected to the outer wall of the left side of the conveying box. The automatic filling and packaging machine for the hotpot condiments is simple in overall structure and can conveniently store and convey the hotpot condiments safely and temporarily, so that the problems of poor safety and poor efficiency when the hotpot condiments need to be temporarily conveyed after filling and packaging are effectively solved.

The invention provides a preparation method and application of a redox-responsive hyperbranched skeleton. The hyperbranched skeleton having a divergent structure is designed by performing crosslinkingon a disulfide bond-containing bifunctional reagent and a low-molecular-weight hyperbranched polymer; and the hyperbranched skeleton is different from a conventional dendritic molecule or a hierarchical bifurcation structure. The periphery of the disulfide bond crosslinked hyperbranched skeleton designed by the invention can graft chitosan to prepare hyperbranched chitosan with redox response, and structural limitation of original linear chitosan is overcome; and the environment-responsive hyperbranched chitosan prepared by adopting the hyperbranched skeleton provided by the invention exhibits excellent biocompatibility and high-efficiency gene delivery performance, and has broad application prospects in the fields of gene therapy and gene editing.

The invention provides a tumor microenvironment response type gene nano-micelle. The tumor microenvironment response type gene nano-micelle comprises polyethyleneimine-phenylboronic acid and polyethyleneimine-maleic anhydride-target radical, wherein the mass ratio of the polyethyleneimine-phenylboronic acid to the polyethyleneimine-maleic anhydride-target radical ranges from (1 to 1) to (1 to 2).The invention further provides a preparation method of the tumor microenvironment response type gene nano-micelle. The invention further provides application of the tumor microenvironment response type gene nano-micelle to preparation of a medicine for treating cancers and application of the tumor microenvironment response type gene nano-micelle serving as a medicine carrier. The nano-micelle provided by the invention can efficiently load and transmit RNA (Ribonucleic Acid) and a medicine with a microenvironment response type gene enters a tumor cell target to play a role; the tumor microenvironment response type gene nano-micelle is especially suitable for loading the RNA for carrying out gene therapy on malignant tumor. The preparation method is simple and convenient and is suitable forlarge-scale production.

The invention discloses a wet-spraying concrete double plunger pump pumping pipe conveying slowdown pulse device for a mine. The device includes an upper pipe and a lower pipe, a box body is distributed between the upper pipe and the lower pipe, and the upper pipe is communicated with the lower pipe through the box body; rotating blades are distributed in the box body and provided with coil springs and include the upper rotating blades and the lower rotating blades. When concrete is normally conveyed between the upper and lower pipes, the S-shaped rotating blades are distributed in the conveying direction of the concrete under the action of the coil springs, and since the rotating blades are distributed in a streamline shape, normal conveying of the concrete is ensured. When there is no pumping pressure, the rotating blades suddenly rotate clockwise under the action of the coil springs or a driving motor, and fluids which are positioned at the upper portions of the rotating blades anddo not flow away in time are flipped to the lower pipe immediately under the action of the upper rotating blades to alleviate the phenomenon that materials are not supplied by pulses continuously.

The invention relates to a large vertical depth solid feeding system and a large vertical depth solid feeding process for filling extracted coal. The system comprises a ground control console, a feeding pipeline and a well-type storage bin, wherein the upper part of the storage bin is provided with an underground observation chamber which is communicated with a crossheading and also provided witha conical buffer for reducing the impact force; the bottom of the conical buffer is provided with a signal sensor for monitoring the bulk height of monitored materials; the lower part of the well-typestorage bin has the shape of a semi-oblique cone; a well wall cleaning device is arranged on the well-type storage bin; and the bottom of the well-type storage bin is provided with a bottom bin feeder which is communicated with a material conveying roadway. Solid filling materials with different compositions are continuously fed into a main channel from a branch pipe through the ground control console, mixed materials are subjected to pressure reduction through the conical buffer on the upper part of the well-type storage bin first, enter the well-type storage bin with the shape of the semi-oblique cone, slide off and are stacked, and feeding is stopped by the ground control console after the bin is full. The invention has the advantages of simple structure, convenient and fast process, convenient implementation, time and labor conservation, and high efficiency and safety.

The invention relates to a coal mining method by filling on a blasting mining face of a thin coal seam and relevant equipment, belonging to the technical field of coal-mining and filling equipment of the thin coal seam. The method comprises the following main steps of: carrying out parallel operation on coal mining and filling under the protection of a same hydraulic bracket, and taking the relevant equipment such as the hydraulic bracket, a solid material scraping plate conveyer and a bridge-type stage loader as basis. The invention is applicable to coal mining operation by filling on the blasting mining face of the thin coal seam below 1.3m.