Traditional Chinese medicinal nano-drug as well as preparation method and application thereof

A nano-drug, traditional Chinese medicine technology, applied in the direction of drug combination, pharmaceutical formula, active ingredient of hydroxyl compounds, etc., can solve the problems of instability and low drug-to-lipid ratio, prevent and treat thrombosis, inhibit cell proliferation and migration, and promote smooth muscle. effect of apoptosis

Active Publication Date: 2019-02-15
SHANGHAI NINTH PEOPLES HOSPITAL SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Traditional liposomes entrap honokiol, most of which are entrapped in the hydrophobic region of the liposome bilayer membrane, with a low drug-to-lipid ratio, and honokiol has a phenol group, which is easy to interact with various ions in the solvent rather unstable

Method used

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  • Traditional Chinese medicinal nano-drug as well as preparation method and application thereof
  • Traditional Chinese medicinal nano-drug as well as preparation method and application thereof
  • Traditional Chinese medicinal nano-drug as well as preparation method and application thereof

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preparation example Construction

[0047] The embodiment of the present invention also discloses a preparation method of a traditional Chinese medicine nano-medicine, which is applied to any of the above-mentioned traditional Chinese medicine nano-medicines, and the method includes the following steps:

[0048] S1. Preparation of mixed materials:

[0049] (1) Select an appropriate amount of silicon dioxide and wait for the next step;

[0050] (2) Select an appropriate amount of small molecule traditional Chinese medicine and wait for the next step;

[0051] (3) Mix the selected silicon dioxide and small molecule traditional Chinese medicine according to an appropriate ratio, etc.

[0052] Wait for the next step;

[0053] (4) Select an appropriate amount of organic solution and wait for the next step.

[0054] S2. Mixing reaction of materials:

[0055] (1) Add the silica / small molecule traditional Chinese medicine mixed material obtained in step 3 of S1 to S1

[0056] In the organic solution obtained in the...

Embodiment 1

[0082] Embodiment 1, the preparation method of mesoporous carrier silica / honokiol

[0083] The mesoporous carrier silica and honokiol were weighed and mixed at a mass ratio of 2:1, placed in a light-proof ep tube, and an appropriate amount of absolute ethanol was added to make the mesoporous carrier silica The concentration in the water ethanol is 2mg / ml, the concentration of honokiol is 1mg / ml, put the ep tube in the mixer and shake overnight, so that the small molecules of honokiol are fully absorbed and accommodated by the mesoporous structure, and the anhydrous After ethanol is blown dry with nitrogen, add the same volume of deionized water to suspend the mesoporous carrier silica / honokiol nanoparticles evenly in deionized water. In order to prevent honokiol from being released from the mesoporous, Cause the disintegration of silicon dioxide, freeze-dry the aqueous solution of mesoporous carrier silicon dioxide / honokiol nanoparticles, and store the freeze-dried powder at...

Embodiment 2

[0085] Example 2. Morphological detection of mesoporous carrier silica / honokiol

[0086] The morphology of the pre-prepared mesoporous carrier silica / honokiol nanoparticles was observed by transmission electron microscopy. The specific method is to use deionized water as the dispersion medium to dilute the above-prepared freeze-dried powder, then take 10 ul of the diluted freeze-dried powder and add it dropwise to a copper grid covered with a carbon film, and after 1 minute, use filter paper to absorb the excess solution, and use Bio-TEM observation of mesoporous carrier silica / honokiol nanoparticles.

[0087] For the morphology of nanoparticles, see figure 2 , the mesoporous structure in mesoporous silica can be seen.

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Abstract

The invention belongs to the technical field of medicines and particularly relates to a traditional Chinese medicinal nano-drug as well as a preparation method and application thereof. A specific construction method for preparation of the traditional Chinese medicinal nano-drug as well as the preparation method and application thereof comprises the following steps: weighing and uniformly mixing mesoporous support silica with small molecular traditional Chinese medicines (such as magnolol, curcumin and platycodin) at a proper proportion, dissolving into a proper amount of organic solvents (suchas absolute ethyl alcohol, trichloromethane and isopropanol), putting a mixture into a mixer, keeping out of the sun, oscillatimg and staying overnight, removing the organic solvents and adding deionized water. The preparation method has the advantage that the mesoporous support silica is accommodated into a mesoporous structure of silica nanoparticles by adsorbing the small molecular traditionalChinese medicine which is difficultly dissolved into the water, so as to form a drug-loading nanoparticle drug. The mesoporous support silica has good biocompatibility, and can be adsorbed on the cell surface and be quickly taken in by cells; after the mesoporous support silica enters the cells, the drug in mesopores is continuously released, the mesoporous support silica disintegrates and is excreted from the body through a urinary system, so that safe and efficient drug delivery is realized.

Description

technical field [0001] The invention relates to the technical field of medicines, in particular to a traditional Chinese medicine nanomedicine and its preparation method and application. Background technique [0002] In recent years, for the treatment of advanced coronary heart disease, most of them require percutaneous coronary intervention. The implantation of the stent improves the coronary stenosis, but also severely damages the integrity of the coronary intima, induces the production and secretion of various cytokines, and the cytokines act on the smooth muscle cells of the vascular media, making the smooth muscle cells change from a quiet state The contractile type dedifferentiates into a proliferative type, and the change of cell phenotype causes a large number of proliferation and migration of smooth muscle cells, forming a new thrombus in the coronary artery [Ma Shaojun. The role of transforming growth factor β1 in the formation of restenosis after vascular injury[J...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/51A61K47/04A61K47/52A61K31/05A61K31/12A61K31/704A61P9/10A61P9/14A61P7/02
CPCA61K9/5115A61K31/05A61K31/12A61K31/704A61K47/52A61P7/02A61P9/10A61P9/14A61K2300/00
Inventor 陆平袁伟恩魏晓盛净蔡文玮成静苑子涵徐阳方志伟
Owner SHANGHAI NINTH PEOPLES HOSPITAL SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
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