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Efficient implementation method of single-molecular mechanical test

An implementation method and technology of molecular mechanics, applied in the field of efficient implementation of single-molecule mechanics testing, can solve problems such as data storage and exchange inconvenience

Inactive Publication Date: 2019-03-08
TIANJIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

In addition, a large amount of original data will be generated during the experiment, and most of the data are invalid data, which also causes some inconvenience for data storage and exchange

Method used

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  • Efficient implementation method of single-molecular mechanical test
  • Efficient implementation method of single-molecular mechanical test
  • Efficient implementation method of single-molecular mechanical test

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Embodiment Construction

[0028] The following is a detailed description of an efficient implementation method of a single-molecule mechanical test of the present invention in conjunction with examples and accompanying drawings.

[0029] The purpose of the present invention is that after the sample pool is placed on the translation stage, the control program can automatically complete data collection and processing, moving path planning of the sample pool (searching for microspheres), judgment of the presence of microspheres, and power spectrum calculation according to the following steps , mechanical testing and analysis, data storage, etc.

[0030] The optical path part is explained as follows:

[0031] as attached figure 1 As shown, the laser light emitted by the laser first passes through the isolator ISO, and then expands the beam through the lens group T1. Half-wave plates HW1, HW2, polarization beam splitter PBS1, and light trap BD form a power adjustment module, which greatly reduces the outp...

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Abstract

The invention relates to an efficient implementation method of single-molecular mechanical test, comprising the steps of enabling a sample cell to move relative to light traps through an actuator, andcapturing microspheres; processing in real time to monitor the double light traps until each light trap contains only single microsphere; stopping the actuator operating, controlling a displacement table to drive the sample cell to do simple harmonic motion in the horizontal direction under certain frequency and amplitude; performing single-molecular mechanical test and storing data; when it is monitored that each light trap contains no single microsphere and if multiple microspheres occur in the light trap, controlling a retaining plate to close and then open to release the microspheres fromthe light traps, controlling a piezoceramic mirror PM to rotate so that the movable light traps are moved to reset positions; if no microspheres occur in the light traps, moving the movable light traps directly to the reset positions.

Description

technical field [0001] The invention relates to a high-efficiency realization method of single-molecule mechanical testing. In particular, it relates to automated methods for single-molecule mechanical testing in optical tweezers systems. Compared with the traditional manual operation mode of the single-molecule mechanical test in the optical tweezers system, the present invention can improve the efficiency of the single-molecule mechanical test, and has great significance for the measurement and test under the optical tweezers system. Background technique [0002] The optical tweezers system can capture and manipulate micro- and nano-scale particles (usually microspheres), and measure the applied force. It has the characteristics of non-contact, non-damage, and high precision. It is widely used in biological single molecules, cells In the field of measurement, it has greatly promoted the development of quantitative biology. The traditional manual operation method of singl...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N21/17
CPCG01N21/17
Inventor 胡春光韩梦柯马国腾李帅胡晓东李宏斌胡小唐
Owner TIANJIN UNIV
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