Application of Anti-pl2l60 Protein Antibody in Preparation of Antitumor Drugs

An anti-tumor drug and antibody technology, applied in the field of biomedicine, can solve the problem that there is no literature on the relationship between anti-PL2L60 protein and cancer treatment, records and so on

Active Publication Date: 2020-06-30
SHANGHAI YIFANKE BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0009] Therefore, PL2L60 protein has the potential as a tumor target, but in the prior art, there is no literature on this, and there is no literature on the relationship between anti-PL2L60 protein and cancer therapy

Method used

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  • Application of Anti-pl2l60 Protein Antibody in Preparation of Antitumor Drugs
  • Application of Anti-pl2l60 Protein Antibody in Preparation of Antitumor Drugs
  • Application of Anti-pl2l60 Protein Antibody in Preparation of Antitumor Drugs

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Embodiment Construction

[0035] The present invention will be described in detail below in conjunction with the embodiments and the accompanying drawings. However, the following examples should not be considered as limiting the scope of the present invention.

[0036] For the experimental methods without specific conditions indicated in the following examples, the conventional conditions or the conditions suggested by the manufacturer are usually followed. Percentages and parts of substances are by volume unless otherwise indicated.

[0037] Materials used in the present invention are as follows:

[0038] Severe Combined Immunodeficiency (SCID) Mice: Mice aged 8-12 weeks were used, and these mice were housed in an animal-safe facility.

[0039] Human cell lines: human breast cancer cell line MDA-MB-231, human lung cancer cell line A549 and human cervical cancer cell line HeLa were all obtained from the American Type Culture Collection (ATCC, Manassas, VA, USA). Cells were maintained in DMEM (Gibco)...

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Abstract

The invention relates to the technical field of medicine, and provides the application of a reagent for inhibiting ectopic expression of PIWIL2 gene in the preparation of antitumor drugs and the application of anti-PIWIL2 gene ectopic expression protein antibody in the preparation of antitumor drugs. Further, the present invention also provides a reagent for inhibiting ectopic expression of PIWIL2 gene or an anti-tumor pharmaceutical composition of an antibody against ectopically expressed protein of PIWIL2 gene. Experiments have proved that treating human or mouse tumor cells with KAO3 during inoculation can effectively inhibit the occurrence of mouse tumors. Furthermore, injection of KAO3 into established lymphoma, breast, lung, and cervical cancers significantly inhibited tumor growth and prolonged the survival of tumor-bearing mice. The inhibitory effect of KAO3 is related to the KAO3-specific antigen expressed on the surface of tumor cells. KAO3 induces tumor cell apoptosis by arresting cell cycle at G2 / M phase, inhibiting DNA synthesis and activating complement. Therefore, anti-PL2L60 mAb (KAO3) is a potential therapeutic candidate for the treatment of cancer.

Description

technical field [0001] The invention belongs to the field of biomedicine, and relates to the application of a reagent for inhibiting the product of the PIWIL2 gene that is activated by dissimilation, and the application of an antibody against the product of the PIWIL2 gene that is activated by the dissimilation in the preparation of anti-tumor drugs, in particular to the application of anti-PL2L60 protein antibodies in the preparation of anti-tumor drugs applications, and pharmaceutical preparations containing the above reagents or antibodies. Background technique [0002] "Cancer immunotherapy" applies immunological principles and methods to improve the immunogenicity of tumor cells and the sensitivity to effector cell killing, stimulate and enhance the body's anti-tumor immune response, and use immune cells and effector molecules to infuse the host body, synergistically The body's immune system kills tumors, inhibits tumor growth, and has good therapeutic effects in variou...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K45/00A61K39/395A61P35/00
CPCA61K45/00C07K16/30A61K2039/505A61P35/00A61K38/00C07K2317/76C07K2317/73C07K2317/734
Inventor 高建新李林凤陆虹旻刘梦瑶
Owner SHANGHAI YIFANKE BIOTECH CO LTD
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