Application of Anti-pl2l60 Protein Antibody in Preparation of Antitumor Drugs

An anti-tumor drug and antibody technology, applied in the field of biomedicine, can solve the problem that there is no literature on the relationship between anti-PL2L60 protein and cancer treatment, records and so on
CN109464669BActive Publication Date: 2020-06-30SHANGHAI YIFANKE BIOTECH CO LTD
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Patent Information

Authority / Receiving Office
CN Β· China
Patent Type
Patents(China)
Current Assignee / Owner
SHANGHAI YIFANKE BIOTECH CO LTD
Publication Date
2020-06-30

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Abstract

The invention relates to the technical field of medicine, and provides the application of a reagent for inhibiting ectopic expression of PIWIL2 gene in the preparation of antitumor drugs and the application of anti-PIWIL2 gene ectopic expression protein antibody in the preparation of antitumor drugs. Further, the present invention also provides a reagent for inhibiting ectopic expression of PIWIL2 gene or an anti-tumor pharmaceutical composition of an antibody against ectopically expressed protein of PIWIL2 gene. Experiments have proved that treating human or mouse tumor cells with KAO3 during inoculation can effectively inhibit the occurrence of mouse tumors. Furthermore, injection of KAO3 into established lymphoma, breast, lung, and cervical cancers significantly inhibited tumor growth and prolonged the survival of tumor-bearing mice. The inhibitory effect of KAO3 is related to the KAO3-specific antigen expressed on the surface of tumor cells. KAO3 induces tumor cell apoptosis by arresting cell cycle at G2 / M phase, inhibiting DNA synthesis and activating complement. Therefore, anti-PL2L60 mAb (KAO3) is a potential therapeutic candidate for the treatment of cancer.
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Description

technical field

[0001] The invention belongs to the field of biomedicine, and relates to the application of a reagent for inhibiting the product of the PIWIL2 gene that is activated by dissimilation, and the application of an antibody against the product of the PIWIL2 gene that is activated by the dissimilation in the preparation of anti-tumor drugs, in particular to the application of anti-PL2L60 protein antibodies in the preparation of anti-tumor drugs applications, and pharmaceutical preparations containing the above reagents or antibodies. Background technique

[0002] "Cancer immunotherapy" applies immunological principles and methods to improve the immunogenicity of tumor cells and the sensitivity to effector cell killing, stimulate and enhance the body's anti-tumor immune response, and use immune cells and effector molecules to infuse the host body, synergistically The body's immune system kills tumors, inhibits tumor growth, and has good therapeutic effects in variou...

Claims

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