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Application of anti-PL2L60 protein antibody in preparing anti-tumor medicine

An anti-tumor drug and antibody technology, applied in the field of biomedicine, can solve the problem that there is no literature on the relationship between anti-PL2L60 protein and cancer treatment, records and so on

Active Publication Date: 2019-03-15
SHANGHAI YIFANKE BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] Therefore, PL2L60 protein has the potential as a tumor target, but in the prior art, there is no literature on this, and there is no literature on the relationship between anti-PL2L60 protein and cancer therapy

Method used

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  • Application of anti-PL2L60 protein antibody in preparing anti-tumor medicine
  • Application of anti-PL2L60 protein antibody in preparing anti-tumor medicine
  • Application of anti-PL2L60 protein antibody in preparing anti-tumor medicine

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Embodiment Construction

[0035] The present invention will be described in detail below in conjunction with the embodiments and the accompanying drawings. However, the following examples should not be considered as limiting the scope of the present invention.

[0036] For the experimental methods without specific conditions indicated in the following examples, the conventional conditions or the conditions suggested by the manufacturer are usually followed. Percentages and parts of substances are by volume unless otherwise indicated.

[0037] Materials used in the present invention are as follows:

[0038] Severe Combined Immunodeficiency (SCID) Mice: Mice aged 8-12 weeks were used, and these mice were housed in an animal-safe facility.

[0039] Human cell lines: human breast cancer cell line MDA-MB-231, human lung cancer cell line A549 and human cervical cancer cell line HeLa were all obtained from the American Type Culture Collection (ATCC, Manassas, VA, USA). Cells were maintained in DMEM (Gibco)...

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Abstract

The invention relates to the technical field of medicines and provides application of a reagent for inhibiting ectopic expression of a PIWIL2 gene in preparing anti-tumor medicines, and application ofa protein antibody for preventing ectopic expression of the PIWIL2 gene in preparing anti-tumor medicines. The invention further provides the reagent for inhibiting ectopic expression of the PIWIL2 gene, or an anti-tumor medicine composition of the protein antibody for inhibiting ectopic expression of the PIWIL2 gene. Tests show that occurrence of mouse tumor can be effectively inhibited when human or mouse tumor cells are treated with KAO3 in inoculation. In addition, by injecting KAO3 into established lymphoma, breast cancer, lung cancer and cervical cancer, tumor growth can be remarkably inhibited, and the survival time of tumor-bearing mice can be prolonged. The inhibition effect to KAO3 is related to KAO3 specific antigen expressed on the surfaces of tumor cells. AKO3 is capable of inducing tumor cell apoptosis by retarding cell cycles, inhibiting DNA (Deoxyribonucleic Acid) synthesis and activating complements at a G2 / M stage. Therefore, anti-PL2L60mAb(KAO3) is a potential treatment candidate medicine for treating cancer.

Description

technical field [0001] The invention belongs to the field of biomedicine, and relates to the application of a reagent for inhibiting ectopic expression of PIWIL2 gene and an antibody against ectopically expressed protein of PIWIL2 gene in the preparation of anti-tumor drugs, in particular to the application of anti-PL2L60 protein antibody in the preparation of anti-tumor drugs, and Pharmaceutical preparations containing the above reagents or antibodies. Background technique [0002] "Cancer immunotherapy" applies immunological principles and methods to improve the immunogenicity of tumor cells and the sensitivity to effector cell killing, stimulate and enhance the body's anti-tumor immune response, and use immune cells and effector molecules to infuse the host body, synergistically The body's immune system kills tumors, inhibits tumor growth, and has good therapeutic effects in various types of cancer, so it is receiving more and more attention. [0003] However, targets fo...

Claims

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Application Information

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IPC IPC(8): A61K45/00A61K39/395A61P35/00
CPCA61K45/00C07K16/30A61K2039/505A61P35/00A61K38/00C07K2317/76C07K2317/73C07K2317/734
Inventor 高建新李林凤陆虹旻刘梦瑶
Owner SHANGHAI YIFANKE BIOTECH CO LTD
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