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Application of AGP1, ORM2 and C9 in differentiating tuberculous pleural effusion from magnant pleural effusion

A technology for malignant pleural effusion and pleural effusion, which is applied in the biological field and can solve the problems of high experimental conditions, difficult promotion, false negatives, etc.

Active Publication Date: 2019-03-19
BEIJING CHEST HOSPITAL CAPITAL MEDICAL UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

In recent years, some advanced molecular biology techniques have been applied to the detection of pleural effusion. For example, nucleic acid amplification detection technology has developed rapidly in the field of tuberculosis, but the positive rate of its diagnosis of tuberculous pleural effusion is not as expected. High, there are still false positive and false negative problems, and the experimental conditions are high, so it is difficult to promote at present

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  • Application of AGP1, ORM2 and C9 in differentiating tuberculous pleural effusion from magnant pleural effusion
  • Application of AGP1, ORM2 and C9 in differentiating tuberculous pleural effusion from magnant pleural effusion
  • Application of AGP1, ORM2 and C9 in differentiating tuberculous pleural effusion from magnant pleural effusion

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Embodiment 1

[0036] Example 1. Differential proteins in patients with tuberculous pleural effusion and malignant pleural effusion

[0037]In this embodiment, α1 acid glycoprotein (Alpha-1-acid glycoprotein 1, AGP1), mucin 2 (Orosomucoid 2 , ORM2) and complement C9 (complement component 9, C9) levels are different between patients with tuberculous pleural effusion and malignant pleural effusion, which can be used to distinguish patients with tuberculous pleural effusion and malignant pleural effusion fluid patients.

[0038] AGP1 is the main acute phase response protein with a molecular weight of 40kDa. ORM2 is an important secreted glycoprotein molecule with a molecular weight of 41-43kDa. ORM2 is an acidic glycoprotein molecule mainly secreted by hepatocytes. C9 is a member of the complement family, an enzyme-active protein present in the serum and tissue fluid of humans and vertebrates, and an important defense factor for the body.

[0039] Inclusion criteria for patients with tuberc...

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Abstract

The invention discloses an application of AGP1, ORM2 and C9 in differentiating tuberculous pleural effusion from magnant pleural effusion. A system for detecting contents of AGP1, ORM2 and C9 disclosed by the invention comprises a system for detecting the content of AGP1, a system for detecting the content of ORM2 and a system for detecting the content of C9. The system for detecting contents of AGP1, ORM2 and C9 can be used for differentiating patients with tuberculous pleural effusion from patients with magnant pleural effusion. The sensitivity is 73.0%, the specificity is 89.4%, and AUC is0.865.

Description

technical field [0001] The invention relates to the application of AGP1, ORM2 and C9 in distinguishing tuberculous pleural effusion from malignant pleural effusion in the field of biotechnology. Background technique [0002] There is about 5-15ml of fluid in the pleural cavity of a normal person to separate the two layers of pleura, which acts as a lubricant during breathing. The amount of pleural fluid is not constant. Normal people also have 500-1000ml of fluid exudation and reabsorption every 24 hours, and the two are in a state of balance. Any reason causes increased exudation and (or) decreased reabsorption, and pleural effusion occurs when fluid in the pleural cavity increases. Among many diseases that can cause pleural effusion, tuberculous pleurisy and malignant pleural diseases are more common. Tuberculous pleurisy is a common clinical extrapulmonary tuberculosis with a high incidence, but due to the limitation of diagnostic techniques, the proportion of confirmed...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/68
CPCG01N33/6893
Inventor 潘丽萍张宗德贾红彦
Owner BEIJING CHEST HOSPITAL CAPITAL MEDICAL UNIV