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Cefadroxil chewable tablets used for pets and preparation method thereof

A cefadroxil chewable tablet and the technology of cefadroxil are applied in the field of pet cefadroxil chewable tablet and preparation thereof, and can solve the problems of poor tablet quality stability, unstable cefadroxil, limited effect of disintegrant, and the like, Achieve the effect of stable indicators, good flavor correction effect, saving material consumption and manpower

Inactive Publication Date: 2019-03-26
FOSHAN NANHAI EASTERN ALONG PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, because the raw material cefadroxil is unstable and easy to degrade under high temperature and high humidity conditions, the quality stability of the tablet product is poor, which is not conducive to long-term storage, and also brings hidden dangers to the safety in clinical use.
At the same time, the wet granulation process has limited effect of disintegrants, and is greatly affected by other factors such as binder concentration, wet mixing time, and moisture after drying. The control of intermediate product moisture and hardness is slightly different. Can cause poor disintegration, resulting in unstable dissolution

Method used

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  • Cefadroxil chewable tablets used for pets and preparation method thereof
  • Cefadroxil chewable tablets used for pets and preparation method thereof
  • Cefadroxil chewable tablets used for pets and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1-6

[0052] According to the ratio of raw materials in the following examples 1-6, take an appropriate amount of each raw material

[0053]

[0054]

[0055] The cefadroxil, filler, disintegrating agent and food attractant in each embodiment group were passed through 80 mesh sieve respectively, mixed and stirred to obtain cefadroxil mixed powder, then lubricant was added, mixed uniformly, and tabletted to obtain The cefadroxil chewable tablet of each embodiment group.

experiment example 1

[0075] Experimental example 1 palatability experiment

[0076] The cefadroxil chewable tablets prepared in Examples 1 to 6 and Tablet 1, Tablet 2 and Tablet 3 prepared in Comparative Example 1, Comparative Example 2 and Comparative Example 3 were tested for palatability.

[0077] (1) In a dog and cat farm in Xinxing County, Yunfu City, Guangdong Province, 49 dogs with respiratory tract, urinary tract, skin or soft tissue infection were selected, and further microscopic examination was judged to be caused by sensitive Staphylococcus, Streptococcus, Pasteurella or 45 sick dogs caused by Klebsiella were selected, and every 5 dogs were classified into a group, which were respectively A, B, C, D, E, F, G, H and I groups. Groups A to I were administered with Examples 1 to 6 and Comparative Example 1, Comparative Example 2, and Comparative Example 3 in turn. The test results are shown in Table 1.

[0078]

[0079] (2) Select 53 cats with respiratory tract, urinary tract, skin or ...

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Abstract

The invention provides cefadroxil chewable tablets used for pets and a preparation method thereof. The cefadroxil chewable tablets used for the pets are mainly prepared from the following raw materials: cefadroxil, filler, a disintegrating agent, phagostimulant and a lubricant; the phagostimulant comprise one or more of phagostimulant a, phagostimulant b and phagostimulant c. After being subjectedto taste masking treatment, the chewable tablets have cool and refreshing taste and a flavor which dogs and cats like, have a good taste modifying effect, the taking compliance of the dogs and the cats is good, and medication is convenient. According to a preparation technology of the cefadroxil chewable tablets used for the pets, production conditions of high temperature and high humidity are avoided, an obtained chewable tablet product is stable in various indexes, storage is facilitated, and the safety and the effectiveness of a medicine are guaranteed.

Description

technical field [0001] The invention relates to the field of pharmaceutical preparations, in particular to a cefadroxil chewable tablet for pets and a preparation method thereof. Background technique [0002] Cefadroxil is a semi-synthetic first-generation oral cephalosporin, a broad-spectrum antibiotic, effective against Staphylococcus pneumoniae, Streptococcus pneumoniae, and Escherichia coli, and also effective against penicillin-resistant Staphylococci. Oral absorption is good, stable in gastric acid after oral administration, and rapid absorption, not affected by food. After oral administration of 22mg / kg in dogs, the peak blood concentration of 18.6μg / ml will be reached within 1-2 hours, only 20% of the drug will be combined with plasma protein, and will be excreted in large quantities in the urine. 50% of parent drug; half-life in cats is approximately 3 hours. It is mainly used for urinary tract, respiratory tract, skin and soft tissue infections caused by sensitiv...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61K47/46A61K47/38A61K31/545A61P31/04
CPCA61K9/0056A61K9/2054A61K9/2059A61K9/2068A61K31/545A61P31/04
Inventor 陶映娴李成应焦晓军
Owner FOSHAN NANHAI EASTERN ALONG PHARMA CO LTD
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