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Absorbable periodontal guided tissue regeneration barrier film and preparation method thereof

A technology that guides tissue regeneration and barrier membranes, applied in surgery, medical science, etc., can solve problems such as poor mechanical strength, and achieve the effects of improving flexibility, high mechanical strength, and increasing flexibility

Active Publication Date: 2021-10-22
CHANGCHUN SINOBIOMATERIALS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the existing absorbable barrier membranes, such as electrospun membranes, or freeze-dried membranes, all have the problem of poor mechanical strength.

Method used

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  • Absorbable periodontal guided tissue regeneration barrier film and preparation method thereof
  • Absorbable periodontal guided tissue regeneration barrier film and preparation method thereof
  • Absorbable periodontal guided tissue regeneration barrier film and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0073] 5g lactide-glycolide-caprolactone terpolymer (number average molecular weight is 150,000 Daltons, LA / GA / CL monomer molar ratio=7 / 2 / 1) and 0.5g hydroxyapatite Stone and 1.0 g polyethylene glycol (number-average molecular weight of 04,000 Daltons) were mixed uniformly and added to 40 mL of N,N-dimethylacetamide together, and the mixture was stirred and dissolved uniformly at 55°C. The material liquid was evenly coated on the glass plate with a film coating machine, and the film thickness was controlled to be 250 μm, and then the glass plate was immersed in a water tank containing distilled water at 15 ° C, and the water was changed every 1 hour, and the water was changed 6 times in total. The membrane was removed from the glass plate and placed in a water tank containing the hydrophilic polymer solution. The hydrophilic polymer is polyethylene glycol-poly(lactide-glycolide) triblock copolymer (PLGA-PEG-PLGA, the number average molecular weight is 577 Daltons-1000 Daltons-...

Embodiment 2

[0081] 5g lactide-glycolide-trimethylene carbonate terpolymer (number average molecular weight is 180,000 Daltons, LA / GA / TMC monomer molar ratio=6 / 2 / 2) and 1g β-phosphoric acid Tricalcium and 1.0 g of polyvinylpyrrolidone (number-average molecular weight of 10,000 Daltons) were mixed uniformly and added to 50 mL of N-methylpyrrolidone together, and the mixture was stirred and dissolved uniformly at 50°C. The material liquid was evenly coated on the glass plate with a film applicator, and the film thickness was controlled to be 400 μm, and then the glass plate was immersed in a water tank containing distilled water at 18 ° C, and the water was changed every 0.8 hours, and the water was changed 9 times in total. The membrane was removed from the glass plate and placed in a sink containing an aqueous solution of type I collagen. The concentration of the type I collagen acetic acid (acetic acid concentration: 0.25 mol / mL) solution was 0.5 wt %, the soaking temperature was 20° C., ...

Embodiment 3

[0085] 5g lactide-glycolide-caprolactone-trimethylene carbonate tetrapolymer (number average molecular weight is 220,000 Daltons, LA / GA / CL / TMC monomer molar ratio=5 / 1 / 2 / 2) blend with 1.5g hydroxyapatite and β-tricalcium phosphate (the mass ratio of hydroxyapatite and β-tricalcium phosphate is 1:1), 1.5g polyethylene glycol monomethyl ether (The number average molecular weight is 05,000 Daltons), mixed uniformly and added to 75 mL of a mixed solvent of N,N-dimethylformamide and ethanol (DMF / ethanol=90 / 10), and stirred to dissolve uniformly at 60°C. The material liquid was evenly coated on the glass plate with a film applicator, and the film thickness was controlled to be 300 μm, and then the glass plate was immersed in a water tank containing distilled water at 22 ° C, and the water was changed every 0.7 hours, for a total of 10 water changes. The membrane was removed from the glass plate and placed in a water tank containing the hydrophilic polymer solution. The hydrophilic ...

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Abstract

The invention provides an absorbable periodontal guided tissue regeneration barrier film, comprising a barrier film; the barrier film is made of a mixed material of hydrophobic macromolecular material and inorganic mineral; the barrier film is adhered to the periodontal soft tissue One side has a dense structure, and the side that is fitted to the periodontal bone defect has a plurality of open pore structures; the pore structures are filled with hydrophilic polymer materials. The barrier film provided by the present invention has a dense structure on one side and a plurality of open pore structures on one side. This structure ensures that the barrier film has high mechanical strength, and at the same time, the performance of the material increases the flexibility of the barrier film, and the porous structure The flexibility is further improved, and the film structure is a single-layer structure. Compared with the current multi-layer structure barrier film, the structure is simple and easy to prepare.

Description

technical field [0001] The invention relates to the technical field of biomaterials, in particular to an absorbable periodontal guiding tissue regeneration barrier film and a preparation method thereof. Background technique [0002] Periodontal disease is one of the common oral diseases in humans. In the early stage of periodontal disease, the structure of the periodontal supporting tissue is destroyed. As the disease progresses, the periodontal attachment structure is gradually lost, eventually resulting in tooth loss. Guided tissue regeneration (GTR) is one of the main surgical methods to regenerate periodontal tissue. In this method, an isolation membrane needs to be used to establish a barrier between the periodontal bone defect and soft tissue, to prevent the gingival epithelium from growing along the root surface during the healing process, and to prevent fibrous connective tissue cells and epithelial cells that interfere with bone formation and migrate faster Enterin...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L31/06A61L31/02A61L31/04A61L31/14
CPCA61L31/028A61L31/044A61L31/048A61L31/06A61L31/14A61L31/146A61L31/148A61L2300/412C08L71/02C08L67/04C08L39/06
Inventor 许午崔立国石旭东孙海李艳红刘爽庄秀丽崔毅
Owner CHANGCHUN SINOBIOMATERIALS
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