A kind of andrographolide nanosuspension
A technology of andrographolide and nanosuspension, applied in the field of medicine, can solve the problems that continuous operation cannot be realized, the process is not simple enough, and the system free energy is high, the dispersion coefficient is small, the increase of the particle size of the preparation is avoided, and the process is simplified and can be control effect
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Embodiment 1
[0045] Example 1 Preparation of Andrographolide Nanosuspension—Comparison of Different Instruments
[0046] prescription:
[0047]
[0048] Process:
[0049] (1) ATS high-pressure homogenizer: Dissolve 0.2 g sodium deoxycholate in distilled water, add 6 g of andrographolide after complete dissolution, and use shear dispersion to completely disperse the drug in the aqueous solution containing stabilizers. The mixed solution was passed through a high-pressure homogenizer, 400 and 800 bar were circulated once, and then 1200 bar was circulated 20 times, and an appropriate amount of andrographolide suspension was taken out to measure the particle size to be 1.1 μm, which could not reach the nanometer level. Reduce the amount of prescription andrographolide to 0.6%, and use the same method to circulate through the high-pressure homogenizer 20 times, take out an appropriate amount of andrographolide suspension and measure the average particle size to be 532 nm.
[0050] (2) Micr...
Embodiment 2
[0054] Preparation of embodiment 2 andrographolide nanosuspensions——crude drug without micronization or through micronization
[0055] Take the unmicronized andrographolide raw material drug, adopt the same prescription as in Example 1 and the method in (4) in Example 1 to prepare andrographolide nanosuspensions, and take out an appropriate amount of andrographolide before grinding for 0.5 h and 1 h The particle size of the ester suspension was determined. Compared with Example 1 (4), that is, the nanosuspension prepared after the micronization of the crude drug. The results are shown in Table 1.
[0056] Table 1 Average particle size of nanosuspension prepared by micronization or non-micronization of andrographolide API
[0057]
[0058] It can be seen from Table 1 that the particle size of the API is smaller after micronization and grinding at the same time. But at the same time, the method of the present invention has a higher grinding efficiency for particles with la...
Embodiment 3
[0059] The preparation of embodiment 3 andrographolide nanosuspensions—adding or not adding stabilizer
[0060] prescription:
[0061]
[0062] Process:
[0063] The process of (4) in Example 1 was used to prepare the andrographolide nanosuspension. Before grinding, take out an appropriate amount of andrographolide nanosuspension from the discharge port at 0.5, 1.0, and 1.5 h to measure the particle size. Compared with the andrographolide nanosuspension prepared by adding stabilizer in Example 2. The results are shown in Table 2.
[0064] Table 2 The average particle size of andrographolide nanosuspension prepared with or without stabilizer in the formulation
[0065]
[0066] It can be seen from Table 2 that after adding the stabilizer, the particle size of the drug particles can be continuously reduced with the increase of the grinding time, but without adding the stabilizer, the drug particles not only did not decrease but increased after grinding for 1 h. It can ...
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