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Preparation method of radix stemonae or honey-fried radix stemonae formula granules

A technology of formula granules and honeydew, which is applied in the direction of pharmaceutical formulas, medical preparations containing active ingredients, plant raw materials, etc., and can solve problems that have not yet been seen

Inactive Publication Date: 2019-04-05
GUANGDONG YIFANG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no report on the preparation of Baibu or Mibubu formula granules by continuous dynamic countercurrent extraction process

Method used

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  • Preparation method of radix stemonae or honey-fried radix stemonae formula granules
  • Preparation method of radix stemonae or honey-fried radix stemonae formula granules

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] A preparation method of Baibu formula granules includes the following steps:

[0043] a. The baibu medicinal materials are selected, shaken to remove impurities, and crushed into 0.5cm particles;

[0044] b. Wet the crushed coarse particles with 2 times water, and continuously input the leaching tube of the spiral continuous countercurrent extractor (two-stage 10-section tube structure) from the feed port, and pass a set of spiral structure in the leaching tube The material is continuously pushed forward to the slag discharge port of the extraction tube, and 16 times the amount of 95 ℃ hot water is continuously added to the end of the extraction tube at each level for continuous countercurrent extraction for 1 hour, and the hot water and the material flow in the reverse direction to each level The front end of the extraction tube discharges the liquid, collects the extract, squeezes the Stemona dregs to recover part of the medicinal solution and then discharges it. The recov...

Embodiment 2

[0049] A preparation method of Baibu formula granules includes the following steps:

[0050] a. Selection of baibu medicinal materials, vibrating sieve to remove impurities, and crushing into 0.5cm particles;

[0051] b. Wet the crushed coarse particles with 2 times water, and continuously input the leaching tube of the spiral continuous countercurrent extractor (two-stage 10-section tube structure) from the feed port, and pass a set of spiral structure in the leaching tube The material is continuously pushed forward to the slag discharge port of the extraction tube, and 16 times the amount of 95 ℃ hot water is continuously added to the end of the extraction tube at each level for continuous countercurrent extraction for 1 hour, and the hot water and the material flow in the reverse direction to each level The front end of the extraction tube discharges the liquid, collects the extract, squeezes the Stemona dregs to recover part of the medicinal solution and then discharges it. The...

Embodiment 3

[0056] A preparation method of Baibu formula granules includes the following steps:

[0057] a. Selection of baibu medicinal materials, vibrating sieve to remove impurities, and crushing into 0.5cm particles;

[0058] b. Wet the crushed coarse particles with 2 times water, and continuously input the leaching tube of the spiral continuous countercurrent extractor (two-stage 10-section tube structure) from the feed port, and pass a set of spiral structure in the leaching tube The material is continuously pushed forward to the slag discharge port of the extraction tube to discharge the slag, and 16 times the amount of 80 ℃ hot water is continuously added to the end of the extraction tube at each level for continuous countercurrent extraction for 1 hour, and the hot water and the material flow in the reverse direction to each level The front end of the extraction tube discharges the liquid, collects the extract, squeezes the Stemona dregs to recover part of the medicinal solution and t...

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Abstract

The invention discloses a preparation method of radix stemonae or honey-fried radix stemonae formula granules. The preparation method comprises the following steps that a, radix stemonae or honey-fried radix stemonae is crushed into coarse particles; b, the coarse particles are continuously input into extraction pipes of a continuous dynamic countercurrent extraction machine, hot water is reversely and continuously added at the tail ends of the extraction pipes of each grade for continuous dynamic countercurrent extraction, an extracting solution is collected, and medicine residues are discharged; c, the extracting solution is filtered and subjected to high temperature instantaneous sterilization, and filtrate is concentrated under reduced pressure to form a clear paste; d, excipients areadded to the clear paste for dissolution, and spray drying is performed to obtain dry extract powder; and e, preparation excipients are added to the dry extract powder, and dry granulation is performed to obtain the radix stemonae or honey-fried radix stemonae formula granules. The preparation method adopts a production process of continuous countercurrent extraction, high temperature instantaneous sterilization, pressure-reduced concentration, spray drying and dry granulation, and researches various process parameters, so that the content of effective elements in the formula granules can becontinuously and stably maintained to achieve a higher level, it is ensured that the active ingredient transfer rate is consistent with standard decoction, and the product quality of the radix stemonae or honey-fried radix stemonae formula granules is improved.

Description

Technical field [0001] The invention belongs to the technical field of traditional Chinese medicine formula granules, and in particular relates to a preparation method of babu or honey babu formula granules. Background technique [0002] Stemone is an erect Stemone Stemona sessilifplia (Miq.) Miq, spurred hundred parts Stemona japonica (Bl.) Miq or Opposite Leaf Stem Stemona tuberosa Lour.'s dry roots. It has the effects of moisturizing the lungs, lowering the air, relieving coughs, killing insects and killing lice. It is used for new chronic coughs, tuberculosis coughs, sudden coughs, external use for head lice, body lice, worm disease, and itchy vulva; Cough due to yin deficiency. In recent years, pharmacological studies have shown that chlorogenic acid has significant cough-reducing and phlegm-reducing effects. Its mechanism of action is to inhibit leukocytosis and block neuraminidase synthesis to inactivate influenza, parainfluenza and respiratory syncytia. And other i...

Claims

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Application Information

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IPC IPC(8): A61K36/904A61K9/16A61P11/00A61P11/14A61K125/00
CPCA61K9/1652A61K9/1682A61K36/904A61K2236/331A61K2236/51A61P11/00A61P11/14
Inventor 程学仁魏梅陈江平黄瑶张志鹏田清清蒋启文刘涛乾蔡盛康
Owner GUANGDONG YIFANG PHARMA
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