A hydrophilic glass slide for medical testing

A glass slide and hydrophilic technology, applied in the field of biomedical supplies, can solve the problems of cells and tissue slices that cannot be firmly adhered, poor mechanical properties, and cannot be resistant at the same time, and achieve low preparation costs and equipment dependence Not high, the effect of excellent materials

Active Publication Date: 2021-07-09
王丽丽
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] In order to overcome the defects in the prior art, the present invention provides a hydrophilic glass slide for medical testing, which overcomes the lack of wettability of the surface of the traditional glass slide. During use, cells and tissue sections It cannot be firmly adhered to the glass slide. During the staining process, due to many factors such as overacid, high temperature, and high pressure, the film will fall off. It cannot be resistant to xylene and methyl ethyl ketone at the same time. It is resistant to boiling, acid, alkali, and dye tests. Breakage, poor mechanical properties, poor weather resistance technical defects, excellent comprehensive performance, low production cost, excellent adhesion and wettability, good mechanical properties and weather resistance, safe and environmentally friendly to use

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] A kind of hydrophilic slide glass that is used for medical detection, it is characterized in that, is first made of two [2-(dimethylamino) ethyl] (2Z)-2-butenedioate and 4,5-di Chlorine-1,3-dioxapentane-2-one is prepared by polycondensation reaction to obtain a polycondensate intermediate, and then the polycondensate intermediate, hydrogen furfuryl acrylate, acrylonitrile, and ethylene glycol dimethacrylate are pressed The mass ratio of 2:1:3:1 is copolymerized to prepare the addition polymer intermediate, which is finally prepared by immersing the addition polymer intermediate in gluconic acid aqueous solution for ion exchange.

[0026] Wherein, the preparation method of the hydrophilic slide for medical detection is realized through the following steps:

[0027] ⅠAdd 18g of bis[2-(dimethylamino)ethyl](2Z)-2-butenedioate and 10g of 4,5-dichloro-1,3-dioxapentane-2-one to In 100 g of diethyl ether, stir and react at 30°C for 6 hours, then remove the solvent by rotary ev...

Embodiment 2

[0031] A kind of hydrophilic slide glass that is used for medical detection, it is characterized in that, is first made of two [2-(dimethylamino) ethyl] (2Z)-2-butenedioate and 4,5-di Chlorine-1,3-dioxapentane-2-one is prepared by polycondensation reaction to obtain a polycondensate intermediate, and then the polycondensate intermediate, hydrogen furfuryl acrylate, acrylonitrile, and ethylene glycol dimethacrylate are pressed The mass ratio of 2:1:3.5:1 is copolymerized to prepare the addition polymer intermediate, which is finally prepared by immersing the addition polymer intermediate in gluconic acid aqueous solution for ion exchange.

[0032] Wherein, the preparation method of the hydrophilic slide for medical detection is realized through the following steps:

[0033] ⅠAdd 18g of bis[2-(dimethylamino)ethyl](2Z)-2-butenedioate and 10g of 4,5-dichloro-1,3-dioxapentane-2-one to In 110 g of dichloromethane, stirred and reacted at 32°C for 6.5 hours, then the solvent was remo...

Embodiment 3

[0037] A kind of hydrophilic slide glass that is used for medical detection, it is characterized in that, is first made of two [2-(dimethylamino) ethyl] (2Z)-2-butenedioate and 4,5-di Chlorine-1,3-dioxapentane-2-one is prepared by polycondensation reaction to obtain a polycondensate intermediate, and then the polycondensate intermediate, hydrogen furfuryl acrylate, acrylonitrile, and ethylene glycol dimethacrylate are pressed The mass ratio of 2:1:4:1 is copolymerized to prepare the addition polymer intermediate, which is finally prepared by immersing the addition polymer intermediate in gluconic acid aqueous solution for ion exchange.

[0038] Wherein, the preparation method of the hydrophilic slide for medical detection is realized through the following steps:

[0039] ⅠAdd 18g of bis[2-(dimethylamino)ethyl](2Z)-2-butenedioate and 10g of 4,5-dichloro-1,3-dioxapentane-2-one to In 130g of tetrahydrofuran, stirred and reacted at 35°C for 7 hours, then the solvent was removed b...

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PUM

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Abstract

The invention discloses a hydrophilic glass slide for medical detection, which is characterized in that it is first prepared by bis[2-(dimethylamino)ethyl](2Z)-2-butenedioate and 4 , 5-dichloro-1,3-dioxa-2-ketone is prepared by polycondensation reaction to obtain a polycondensate intermediate, and then the polycondensate intermediate, hydrogen furfuryl acrylate, acrylonitrile, ethylene glycol dimethyl Acrylic acid esters are prepared by copolymerization at a mass ratio of 2:1:(3‑5):1 ​​to obtain an addition polymer intermediate, and finally the addition polymer intermediate is soaked in gluconic acid aqueous solution for ion exchange. The hydrophilic glass slide for medical detection disclosed by the invention has the advantages of excellent comprehensive performance, low production cost, excellent adhesion and wettability, good mechanical properties and weather resistance, and safe and environment-friendly use.

Description

technical field [0001] The invention relates to the technical field of biomedical supplies, in particular to a hydrophilic glass slide for medical testing. Background technique [0002] With the development of science and technology, glass slides for medical and biological testing are widely used in cytological diagnosis, pathological experiments, HPV detection, etc. People have high requirements for their performance, and the market demand is large. At present, the common glass slides are hydrophobic adhesive glass slides, which often appear in the process of histology, immunohistocytochemistry, frozen section, specimen preparation, tissue cell sectioning and in situ hybridization, etc. The problem. In addition, after being sealed and used, it cannot be reused. Damaged and discarded glass specimens will cause a certain amount of medical waste, which is very difficult to dispose of. [0003] Pathological techniques are changing with each passing day, especially immunohisto...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N1/31
CPCG01N1/31
Inventor 王丽丽谭举朋
Owner 王丽丽
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