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Spleen-refreshing and child-nourishing granules, and preparation method and quality control method thereof

A quality control method and granule technology, which are applied in measuring devices, pharmaceutical formulations, medical preparations containing active ingredients, etc., can solve the problem of undisclosed preparation methods of Xingpi Yanger granules, unsatisfactory treatment effect, and no Xingpi Yanger granules. Quality identification standards and other issues, to achieve the effect of controlling product quality, good product quality, and simple extraction methods

Active Publication Date: 2019-05-03
贵州健兴药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Deficiency of the spleen causes anorexia, diarrhea and loose stools, resulting in weight loss and weakness, sweating and enuresis; in this case, it is necessary to wake up the spleen and whet the appetite, replenish qi and invigorate the deficiency, strengthen the intestines and relieve diarrhea; existing medicines include appetizers, invigorating the spleen Drugs in this area can play a certain role, but their therapeutic effect is not particularly ideal
The publication number is CN1415325A, which discloses a traditional Chinese medicine preparation for refreshing spleen, appetizing, nourishing qi and invigorating deficiency, but does not disclose the preparation method of Xingpi Yanger granules, and there is no quality appraisal standard for Xingpi Yanger granules

Method used

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  • Spleen-refreshing and child-nourishing granules, and preparation method and quality control method thereof
  • Spleen-refreshing and child-nourishing granules, and preparation method and quality control method thereof
  • Spleen-refreshing and child-nourishing granules, and preparation method and quality control method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Embodiment 1, the preparation method of Xingpi Yanger Granules

[0022] The preparation method of Xingpi Yanger Granules comprises the following steps: take 360g of a little red, 326g of gerbera, 210g of mountain gardenia tea and 72g of spider incense, soak in warm water at 40-60°C for 30 minutes, decoct for 2 times, the first time 2 1.5 hours for the second time, combine the decoction, filter, concentrate the filtrate to a clear paste with a relative density of 1.15-1.18 (80°C), add an appropriate amount of sucrose powder, mix well, make granules, dry, and make 1000g, that is have to.

[0023] Control group: Xingpi Yanger granules prepared with the publication number CN1415325A were used, and then the yield of solids and product extracts were determined by the method of the present invention and the control group. The results are shown in Table 1.

[0024] Table 1. Xingpi Yanger Granule Extract Solids and Product Extraction Yield

[0025] serial number

[0...

Embodiment 2

[0027] Embodiment 2, the quality control method of Xingpi Yanger Granules

[0028] (1) Yidianhong identification: take 5 parts of clear paste 3g in the preparation process of Xingpi Yanger Granules in Example 1, add 2 drops of concentrated ammonia test solution, add 20ml of chloroform, ultrasonicate for 20 minutes, filter, and evaporate the filtrate to dryness. Add 1ml of methanol to the residue to dissolve it, and use it as the test solution; in addition, take 5g of a little red reference medicinal material (batch number: 121359-200703 source: China Institute for the Control of Pharmaceutical and Biological Products), add 100ml of water, heat and reflux for 1 hour, let cool, filter, and filtrate Concentrate to about 30ml, add 30ml of ethanol, stir well, filter, steam the filtrate until it has no alcohol smell, shake and extract twice with ethyl acetate, 30ml each time, combine the ethyl acetate solution, and use 4% sodium bicarbonate Wash with 20ml of the solution, then wash ...

Embodiment 3

[0030] Example 3, Xingpi Yanger Granule drug efficacy verification

[0031] In order to prove the medicinal effect of Xingpi Yanger Granules, the specific methods for improving immunity of Xingpi Yanger Granules are as follows:

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Abstract

The invention relates to spleen-refreshing and child-nourishing granules, and a preparation method and quality control method thereof. The spleen-refreshing and child-nourishing granules are preparedaccording to the following method: taking sowthistle tasselflower herb, pilose gerbera herb, pittosporm roots and rhizomes of broadleaf common valeriana according to a prescription amount, adding warmwater at 40-60 DEG C for soaking for 0.5h, performing decocting twice, combining decoctions, performing filtering, concentrating the obtained filtrate to a clear paste with a relative density of 1.15-1.18 (80 DEG C), adding auxiliary materials, and performing granulation. The method can sufficiently retain active ingredients. The invention also discloses a quality control method for the spleen-refreshing and child-nourishing granules, and the method can better control the product quality.

Description

technical field [0001] The invention belongs to the field of pharmacy, and relates to a preparation method of Xingpi Yanger Granules and a quality control method of Xingpi Yanger Granules. Background technique [0002] Deficiency of the spleen causes anorexia, diarrhea and loose stools, resulting in weight loss and weakness, sweating and enuresis; in this case, it is necessary to wake up the spleen and appetizer, replenish qi and invigorate the deficiency, strengthen the intestines and relieve diarrhea; existing medicines include appetizers, invigorating the spleen Drugs in this area can play a certain role, but their therapeutic effect is not particularly ideal. The publication number is CN1415325A, which discloses a traditional Chinese medicine preparation for refreshing the spleen, appetizing, replenishing qi and invigorating deficiency, but does not disclose the preparation method of Xingpi Yanger granules, and there is no quality appraisal standard for Xingpi Yanger gra...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/16A61K36/84A61P1/12A61P1/14G01N30/90
Inventor 孙小鸚廖萍廖伟廖忠
Owner 贵州健兴药业有限公司
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