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A kind of dissolvable self-healing natural polymer hydrogel and preparation method thereof

A natural polymer and hydrogel technology, applied in bandages, surgery, surgical adhesives, etc., can solve the problems of insolubility, slow healing speed, and limitation of incision healing, and achieve long release time, stable release rate, and healing efficiency high effect

Active Publication Date: 2021-06-25
EAST CHINA NORMAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The purpose of the present invention is to provide a soluble self-healing natural polymer hydrogel and its preparation in order to solve the problems of slow healing speed, limited incision healing and insolubility in the existing self-healing hydrogel The method has abundant sources of raw materials, is environmentally friendly, has a simple preparation method, is economical and has good biocompatibility

Method used

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  • A kind of dissolvable self-healing natural polymer hydrogel and preparation method thereof
  • A kind of dissolvable self-healing natural polymer hydrogel and preparation method thereof
  • A kind of dissolvable self-healing natural polymer hydrogel and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0039] Synthesis of Soluble Self-Healing Hydrogel (SAM-1)

[0040] Weigh a certain amount of sodium alginate and add it to deionized water (the mass ratio of sodium alginate to deionized water is 4:100), stir at 1500rpm for 3 hours until the sodium alginate is completely dissolved, put the sodium alginate solution in Put it in a refrigerator at 3°C, stabilize it for 3 hours, and wait until it becomes a colorless and transparent sodium alginate aqueous solution.

[0041] Add the prepared sodium alginate aqueous solution into a three-necked flask, stir at 1500 rpm for 10 minutes, then slowly add deionized water (the mass ratio of sodium alginate solution to deionized water is 4:1), maintain the stirring speed, and continue stirring For 30 minutes, the temperature was kept at 25°C.

[0042] To the mixed sodium alginate solution, slowly add methacrylic acid dropwise (the mass ratio of sodium alginate mixed solution to methacrylic acid is 8:1), the dropwise addition is completed w...

Embodiment 2

[0045] Synthesis of Soluble Self-Healing Hydrogels (SAM-2)

[0046] Weigh a certain amount of sodium alginate and add it to deionized water (the mass ratio of sodium alginate to deionized water is 2:100), stir at 1200rpm for 5 hours until the sodium alginate is completely dissolved, put the sodium alginate solution in Put it in a refrigerator at 8°C, stabilize it for 6 hours, and wait until it becomes a colorless and transparent sodium alginate aqueous solution.

[0047] Add the prepared sodium alginate aqueous solution into a three-necked flask, stir at 1200rpm for 10 minutes, then slowly add deionized water (the mass ratio of sodium alginate solution to deionized water is 4:2), maintain the stirring speed, and continue stirring 50min, the temperature was kept at 25°C.

[0048] To the mixed sodium alginate solution, slowly add methacrylic acid (the mass ratio of sodium alginate mixed solution to methacrylic acid is 4:1), the dropwise addition is completed within 2 hours, kee...

Embodiment 3

[0051] Synthesis of Soluble Self-Healing Hydrogel (SAM-3)

[0052] Weigh a certain amount of sodium alginate and add it to deionized water (the mass ratio of sodium alginate to deionized water is 1:100), stir at 800rpm for 6 hours until the sodium alginate is completely dissolved, put the sodium alginate solution in Put it in a refrigerator at 10°C, stabilize it for 10 hours, and wait until it becomes a colorless and transparent sodium alginate aqueous solution.

[0053] Add the prepared sodium alginate aqueous solution into the three-necked flask, stir at 800rpm for 10 minutes, then slowly add deionized water (the mass ratio of sodium alginate solution to deionized water is 4:3), maintain the stirring speed, and continue stirring For 60 minutes, the temperature was kept at 25°C.

[0054] To the mixed sodium alginate solution, slowly add methacrylic acid (the mass ratio of sodium alginate mixed solution to methacrylic acid is 2:1), and the dropwise addition is completed withi...

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Abstract

The invention discloses a dissolvable self-healing natural polymer hydrogel and a preparation method thereof. The natural polymer sodium alginate is used as a raw material, the functional monomer methacrylic acid is introduced, and an initiator and deionized water are used as auxiliary raw materials. , a natural polymer hydrogel (SAM) with excellent self-healing properties and solubility was prepared by a one-pot method. The hydrogel prepared by the invention has a fast self-healing rate, the healing is not limited by the section of the incision, and has good solubility. When the hydrogel is put into a certain amount of water, the hydrogel can be completely dissolved without residue , using it as a drug carrier, its release rate is stable, and the drug can achieve 100% complete release without residue. And the prepared hydrogel has good biocompatibility and degradability, and the dissolvable self-healing natural polymer hydrogel prepared by the present invention is used in the field of biomedical materials such as wound dressings, tissue and organ culture and biological scaffold materials. It has broad application prospects.

Description

technical field [0001] The invention belongs to the technical field of polymer materials, in particular to a natural polymer hydrogel (SAM) with dissolving and self-healing properties and a preparation method thereof. Background technique [0002] Self-healing hydrogel means that when the hydrogel itself is damaged by external force, the hydrogel can achieve self-healing through a dynamic cross-linked network. Self-healing hydrogels can not only guarantee the excellent swelling properties, mechanical toughness, biocompatibility, and easy modification of the hydrogel itself, but more importantly, the excellent self-healing properties make hydrogels gain a lot of attention in the field of biomaterials. Widespread concern. Wound healing is a complex biological process that includes coagulation, inflammation, exudation, synthesis, and regeneration. Due to the exudation of wound tissue fluid, traditional wound dressings often adhere to the wound, causing secondary trauma when c...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08J3/075C08L5/04C08L33/02C08F120/06A61L24/08A61L24/00A61L26/00
Inventor 徐敏黄海龙王艳玲付晓彬
Owner EAST CHINA NORMAL UNIV
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