A small molecule inhibitor containing 2,6-dihydroxypurine and its application in inhibiting ornithine decarboxylase (odc)

Abstract

The invention provides a small molecule inhibitor containing 2,6-dihydroxypurine, the small molecule inhibitor is 1,3-dimethyl-8-(2-thienyl)-3,7-dihydro-1H- Purine-2,6-diketone, its structural formula is: the present invention will contain the 2,6-dihydroxypurine small molecule inhibitor in the application of inhibiting ornithine decarboxylase (ODC), and in the preparation of the drug for treating tumor application, and in the preparation of medicines for the treatment of pathogenic microorganism infections, and achieved remarkable results.

Description

technical field [0001] The invention relates to a small-molecule inhibitor of ornithine decarboxylase (Ornithine decarboxylase; ODC) and its application, in particular to a small-molecule inhibitor of human ornithine decarboxylase and its application in inhibiting and killing tumor cells. Background technique [0002] Protein is one of the main components of organisms and the main substance to complete various life activities. Among various proteins, proteases are crucial to life activities, and almost all biochemical reactions in organisms are catalyzed by proteases. The activity of various proteases in organisms has a strict regulation mechanism. Once there is a problem with the regulation mechanism, the activity of proteases is too high, too low or completely inactivated, which will cause various diseases. Therefore, it has very important theoretical and practical significance to regulate the activity of protease by drugs to restore and maintain it at a normal level. St...

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Problems solved by technology

However, its binding ability to ODC is weak, and its concentration is very high, and because it is a suicide inhibitor that forms a covalent bond with ODC, its toxic and side effects are very large

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